A5041897081- Cardiac, Anesthesia and Surgical Outcomes
- Muscle Physiology and Disorders
- Genomics and Chromatin Dynamics
- Skin Protection and Aging
- Hair Growth and Disorders
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Transplantation: Methods and Outcomes
- Acute Myocardial Infarction Research
- Body Contouring and Surgery
- Adipose Tissue and Metabolism
- Health and Medical Studies
- Immune Response and Inflammation
- RNA modifications and cancer
- Nitric Oxide and Endothelin Effects
- High Altitude and Hypoxia
- Cardiac and Coronary Surgery Techniques
- Psychology, Coaching, and Therapy
- Single-cell and spatial transcriptomics
- Parathyroid Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Education Methods and Technologies
- Magnesium in Health and Disease
- Viral Infections and Immunology Research
University of Colorado Anschutz Medical Campus
2024
University of Michigan
2021-2023
BioSurfaces (United States)
2020-2023
Yale University
2019-2020
University of Graz
1993-1994
Marymount University
1994
Universitätsklinik für Frauenheilkunde und Geburtshilfe
1993
Volumetric muscle loss (VML) overwhelms the innate regenerative capacity of mammalian skeletal (SkM), leading to numerous disabilities and reduced quality life. Immune cells are critical responders injury guide tissue resident stem cell– progenitor-mediated myogenic repair. However, how immune cell infiltration intercellular communication networks with altered following VML drive pathological outcomes remains underexplored. Herein, we contrast cellular molecular mechanisms injuries that...
Age-related skeletal muscle atrophy or sarcopenia is a significant societal problem that becoming amplified as the world's population continues to increase. The regeneration of damaged mediated by stem cells, but in old age cells become functionally attenuated. molecular mechanisms govern cell aging encompass changes across multiple regulatory layers and are integrated three-dimensional organization genome. To quantitatively understand how hierarchical chromatin architecture during aging, we...
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume function impacting mobility quality life. Muscle often associated with denervation resident stem cells (satellite or MuSCs); however, the relationship between MuSCs innervation has not been established. Herein, we administered severe trauma to transgenic murine model that permits MuSC lineage tracing. We show subset specifically engraft in position proximal junction (NMJ), synapse myofibers motor...
Troponin-T is one of the contractile proteins myocardium. Its release into circulation indicates various degrees myocardial cell damage. may be measured in serum with a recently developed enzyme immunoassay. This immunoassay was used to evaluate preoperative damage patients stable and unstable angina undergoing elective coronary artery bypass graft surgery, it compared conventional assays creatine kinase (CK) MB isoenzyme activity mass.Twenty-one 31 were studied. Troponin-T, CK-MB activity,...
Capsaicin-sensitive afferent neurons control blood flow via release of peptide transmitters and formation nitric oxide (NO). The present study examined whether capsaicin-sensitive NO interact in the hemostasis. Afferent nerve ablation by pretreating rats with a neurotoxic dose capsaicin (125 mg/kg) led to 26% reduction time bleeding from punctured small mesenteric arteries pentobarbital-anesthetized animals. Blockade NG-nitro-L-arginine methyl ester (L-NAME; 10 attenuated...
INTRODUCTION: Mechanisms contributing to the post-acute sequelae of SARS-CoV-2 (PASC, aka Long COVID) and associated functional limitations are unclear. RESEARCH QUESTION: Determine cardiovascular, autonomic exercise physiology among patients with COVID. METHODS: Twenty-one COVID (16 females, 41±12yrs) underwent cardiovascular assessment during head-up tilt at supine, 30 o 60 , a 10-minute upright standing orthostatic challenge cardiopulmonary testing (CPET). Baroreceptor sensitivity was...
Von 159 Schwangeren wurden Blutproben zur Bestimmung der Magnesiumkonzentrationen entnommen. Bei 19 Patientinnen wurde eine schwere, bei 64 leichte schwangerschaftsinduzierte Hypertonie diagnostiziert. 76 Probandinnen mit komplikationslosem Graviditätsverlauf dienten als Vergleichskollektiv. Aufgrund vorliegenden Resultate scheint ein erniedrigter Magnesiumgehalt im Serum allein nicht ursächlich für die Entstehung einer schwangerschaftsinduzierten verantwortlich zu sein.
Abstract Age-related skeletal muscle atrophy or sarcopenia is a significant societal problem that becoming amplified as the world’s population continues to increase. A critical contributor loss in number and function of stem cells, which maintain tissue homeostasis regenerate damage. The molecular mechanisms govern cell aging encompass changes across multiple regulatory layers are integrated by three-dimensional organization genome. To quantitatively understand how hierarchical chromatin...