A5020226744- Reproductive tract infections research
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Syphilis Diagnosis and Treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
University of North Carolina at Chapel Hill
2017-2019
University of Maryland, Baltimore
2019
Chlamydia trachomatis can cause reproductive morbidities after ascending to the upper genital tract of women, and repeated infection lead worse disease. Data related protective immune responses at cervical mucosa that could limit chlamydial cervix and/or prevent reinfection inform vaccine approaches biomarkers risk.We measured 48 cytokines in secretions from women having alone (n = 92) or both endometrial 68). Univariable regression identified associated with differential odds risk,...
Abstract Sexually transmitted infections with Chlamydia trachomatis and/or Neisseria gonorrhoeae and rates of pelvic inflammatory disease (PID) in women continue to rise, reinfection being common because poor adaptive immunity. Diagnosis remains imprecise, pathogenesis data are derived primarily from monoinfection mice C. or N. gonorrhoeae. By comparing blood mRNA responses trachomatis– gonorrhoeae–induced PID histologic endometritis those infection limited their cervix asymptomatic...
Abstract Untreated HIV infection is characterized by generalized immune activation, T cell dysfunction, and ultimately the exhaustion of HIV-specific CD8 responses. Durable virus suppression resulting from anti-retroviral therapy (ART) associated with greatly improved function, but some phenotypic functional abnormalities persist even after years suppressive ART. We have observed that, relative to HIV-seronegative individuals, cells HIV+ participants on ART are skewed toward a more...