A5073646870- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Cancer Genomics and Diagnostics
- Complement system in diseases
- Immune Cell Function and Interaction
- Renal and Vascular Pathologies
- Protein Tyrosine Phosphatases
- Advanced MRI Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Traumatic Brain Injury Research
- Nonmelanoma Skin Cancer Studies
- Spatial Neglect and Hemispheric Dysfunction
- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- PARP inhibition in cancer therapy
- Tactile and Sensory Interactions
CSL (Australia)
2023-2024
Ospedale San Bortolo
2020-2024
John Peter Smith Hospital
2021
Lebanese University
2018
Peter MacCallum Cancer Centre
2015-2017
Anna Needs Neuroblastoma Answers
2017
The University of Melbourne
2017
King Fahd Armed Forces Hospital
2015
Monash University
2008-2015
Centre International de Recherche sur le Cancer
2006-2007
Abstract Cervical cancer development is linked to the persistent infection by high-risk mucosal human papillomaviruses (HPVs) types. The E6 and E7 major oncoproteins from this dsDNA virus play a key role in deregulation of cell cycle, apoptosis, adaptive immune surveillance. In study, we show for first time that HPV type 16 (HPV16), most carcinogenic among subgroup, interferes with innate immunity affecting expression TLRs. Infection primary keratinocytes HPV16 recombinant retroviruses...
BRCA1 -mutated tumors may be particularly vulnerable to dual checkpoint inhibition.
Background Understanding the cancer genome is seen as a key step in improving outcomes for patients. Genomic assays are emerging possible avenue to personalised medicine breast cancer. However, evolution of during natural history largely unknown, profile disease at death. We sought study detail these aspects advanced cancers that have resulted lethal disease. Methods and Findings Three patients with oestrogen-receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative...
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation associated significantly lower levels and while MEK inhibition can promote recruitment to the tumor, here we show that adversely affects early onset T-cell effector function. We α-4-1BB α-OX-40 agonist antibodies rescue adverse effects on T cells both mouse human cells, which results augmented anti-tumor vivo. This effect dependent upon increased...
Metastatic disease is the major cause of breast cancer-related death and despite many advances, current therapies are rarely curative. Tumor cell migration invasion require actin cytoskeletal reorganization to endow cells with capacity disseminate initiate formation secondary tumors. However, it still unclear how these migratory colonize distant tissues form macrometastases. The E6-associated protein, E6AP, acts both as an E3 ubiquitin-protein ligase a coactivator steroid hormone receptors....
Background and Purpose: Spontaneous visual recovery is rare after cortical blindness. While rehabilitation may improve performance, no therapy has been widely adopted, as clinical outcomes are variable rarely translate into improvements in activities of daily living (ADLs). We explored the potential value a novel approach “cognitive therapeutic exercises” for Case Description: The subject this case study was 48-year-old woman with blindness tetraplegia cardiac arrest. Prior to intervention,...
Eph receptors and their corresponding membrane-bound ephrin ligands regulate cell positioning establish tissue patterns during embryonic oncogenic development. Emerging evidence suggests that assembly of polymeric signalling clusters relies on cytoskeletal reorganisation underlies regulation by protein tyrosine phosphatases (PTPs). PTP-PEST is a central regulator actin dynamics. Here we demonstrate an N‑terminal fragment PTP-PEST, generated through ephrinA5-triggered, spatially confined...
Abstract Pseudoprogression (PP) is a diagnostic dilemma in the follow‐up of brain high grade gliomas (HGG), and introduction new therapies has further complicated its identification Magnetic Resonance Imaging (MRI). We report case pseudoprogression after intraoperative radiotherapy (ioRT) Regorafenib therapy patient with anaplastic astrocytoma recurrence. A 65‐year‐old man, treated August 2017 for right frontal astrocytoma, surgical resection following Temozolomide, October 2019 was again...
Lapatinib alone or in combination with other agents, mostly capecitabine is used for patients advanced/metastatic HER2 positive breast cancer (HER2(+)BC) after progression on trastuzumab based therapy. Here we report our experience lapatinib therapy this setting.67 consecutive received 58 (86.6%) + (LC), 7 (10.4%) agents and 2 (3.0%) as single agent lapatinib. Data was collected from patients' records retrospectively.Objective response to 64 evaluable 64.0% all who LC. Median free survival...
The aim of this work was to optimize a three-dimensional (3D) turbo-spin-echo (TSE) sequence using small field-of-view (FOV) technique for the study cerebellopontine angle and compare it with constructive interference steady-state (CISS) sequence.
CSL040 is a soluble, recombinant fragment of the complement receptor 1 (CR1) extracellular domain that acts as an inhibitor all three pathways system. Systemic toxicity, toxicokinetics (TK), and pharmacodynamics (PD) were assessed in two-week intravenous (IV) bolus studies Han Wistar rats cynomolgus monkeys. Recovery from any effects was evaluated during four-week recovery period. Daily repeat-dose administration for 2 weeks at doses up to 500 mg/kg IV well tolerated monkeys, leading no...
Summary Anorexia nervosa is a psychiatric eating disorder related to malnutrition and consequent altered metabolism. A 48‐year‐old female with history of anorexia in the last 2 years referred our hospital spinal pain. She underwent X‐ray magnetic resonance imaging (MRI) showing multiple vertebral collapses dorsal lumbar spine inversion normal bone marrow soft tissue signal T1‐weighted STIR images. We describe this case ‘flip‐flop’ phenomenon, underlining how what seems technical failure...
Abstract Metastatic disease is the major cause of breast cancer related death and despite many advances, current therapies are rarely curative. Tumor cell migration invasion require actin cytoskeletal reorganisation, to endow cells with capacity disseminate initiate formation secondary tumors. However, it still unclear how these migratory colonise distant tissues form macrometastases. The E6-associated protein, E6AP, acts both as an E3 ubiquitin-protein ligase a coactivator steroid hormone...
Renal size varies with age, gender, body mass index, pregnancy and co-morbid conditions. Among different growth parameters, kidney’s is considered a critical criterion used not only in clinical evaluation of renal growth, rather abnormalities, diseases. Conventionally, kidney measured roentgenologically. Nowadays, non-invasive ultrasonography has come into general use as screening test for the kidneys. Since affected by several factors, it necessary to first establish normal values. In our...
Background: Recent advances in genomic analyses provide a comprehensive view of the tumour-to-tumour complexity glioma.Subgroups have been defined based on distinct genetic and epigenetic alterations gene expression profiles.IDH1gene mutation is among first observed during development glioma.SOX2 transcriptional co-factors that are associated with various developmental milestones over-expressed tumours, It plays role maintaining pluripotency several cancers. Aim Study:Evaluate correlation...
<div>Abstract<p>Metastatic disease is the major cause of breast cancer–related death and despite many advances, current therapies are rarely curative. Tumor cell migration invasion require actin cytoskeletal reorganization to endow cells with capacity disseminate initiate formation secondary tumors. However, it still unclear how these migratory colonize distant tissues form macrometastases. The E6-associated protein, E6AP, acts both as an E3 ubiquitin-protein ligase a coactivator...