A5029342859- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Polydiacetylene-based materials and applications
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Chemical Synthesis and Analysis
- Construction Project Management and Performance
- Quantum, superfluid, helium dynamics
- Supramolecular Chemistry and Complexes
- Bacterial Genetics and Biotechnology
- Luminescence and Fluorescent Materials
- Geotechnical Engineering and Soil Mechanics
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Landslides and related hazards
- Geotechnical Engineering and Underground Structures
- Law, logistics, and international trade
- Protein Structure and Dynamics
- Bacteriophages and microbial interactions
- Force Microscopy Techniques and Applications
- Diatoms and Algae Research
- Photosynthetic Processes and Mechanisms
- Planetary Science and Exploration
- Antimicrobial agents and applications
- Gas Sensing Nanomaterials and Sensors
Rutherford Appleton Laboratory
2021-2025
ISIS Neutron and Muon Source
2023-2025
Carnegie Mellon University
2024
Science and Technology Facilities Council
2021-2024
University of Warwick
2019-2023
Langley Research Center
2023
Diamond Light Source
2017-2022
University of Birmingham
2017-2022
Coventry (United Kingdom)
2021
Pacific University
2006
Artificial light-harvesting systems in aqueous media which mimic nature are of significant importance; however, they often restrained by the solubility and undesired aggregation-caused quenching effect hydrophobic chromophores. Here, we report a generalized strategy toward construction efficient artificial based on supramolecular peptide nanotubes water. By molecularly aligning chromophores along slipped manner, an system with two-step sequential Förster resonance energy transfer process is...
Positively charged poly(styrene-<italic>co</italic>-maleimide) extracts functional membrane proteins into nanodiscs, overcoming some limitations of current nanodisc technology.
Abstract Biological characterisation of membrane proteins lags behind that soluble proteins. This reflects issues with the traditional use detergents for extraction, as surrounding lipids are generally lost, adverse structural and functional consequences. In contrast, styrene maleic acid (SMA) copolymers offer a detergent-free method biological solubilisation to produce SMA-lipid particles (SMALPs) containing together their lipid environment. We report development reverse-phase LC-MS/MS...
Abstract Typically, the morphologies of self‐assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation materials with unique shape structures, cylindrical soft matter particles (tubisomes), obtained hierarchical self‐assembly cyclic peptide‐bridged amphiphilic diblock copolymers. The capacity photo‐responsive tubisomes as potential drug carriers is evaluated. supramolecular pave an alternative way for fabricating...
Accurate, cost-efficient, and safe hydrogen sensors will play a key role in the future economy. Optical based on metal hydrides are attractive owing to their small size costs fact that they intrinsically safe. These rely suitable sensing materials, of which optical properties change when absorb if contact with hydrogen-containing environment. Here, we illustrate how can use alloying tune hydrogen-sensing materials by considering thin films consisting tantalum doped ruthenium. Using...
Abstract Equilibrium formation conditions for carbon dioxide hydrate were measured in pure water and aqueous polymer electrolyte solutions. The solutions that used include: polyethylene oxide, partially (10 90 percent) hydrolyzed polyacrylamide, sodium chloride calcium chloride. Experiments with containing both polymers also performed. It was found the electrolytes exhibited a substantial inhibiting effect whereas only slightly altered equilibrium conditions. pressures compared predictions...
Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that wraps around segment lipid bilayer, and as such capable encapsulating membrane proteins directly from the cell membrane. To date, most studies on these have used poly(styrene-co-maleic acid) (SMA) with term SMA-lipid particles (SMALPs) coined to describe them. In this study, we determined physical thermodynamic properties made two different SMA copolymers. These include widely commercially available...
Polymeric cylinders, a fascinating type of nanostructures with high surface area, internal volume and rigidity, have been exploited as novel drug delivery vehicles over the past decade. However, it's still an open challenge to afford cylindrical using polymeric building blocks via traditional self-assembly processes. Herein, we report hierarchical strategy preparing aggregates (tubisomes) from amphiphilic supramolecular bottlebrush polymer in which cyclic peptide nanotube is employed...
Activity tests for synthetic antimicrobial compounds are often limited to the minimal inhibitory concentration assay using standard media and bacterial strains. In this study, a family of acrylamide copolymers that act as mimics peptides were synthesized shown have disruptive effect on membranes structural integrity through microscopy techniques membrane polarization experiments. The polymers tested their properties mimic clinically relevant conditions. Additionally, activity was compared in...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLead Pollution and poisoningStephen HallCite this: Environ. Sci. Technol. 1972, 6, 1, 30–35Publication Date (Print):January 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/es60060a008https://doi.org/10.1021/es60060a008research-articleACS PublicationsRequest reuse permissionsArticle Views773Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of...
We report the polymerisation-induced self-assembly of poly(lauryl methacrylate)-graft-poly(benzyl methacrylate) copolymers during reversible addition-fragmentation chain transfer (RAFT) grafting from polymerisation in a backbone-selective solvent. Electron microscopy images suggest phase separation grafts to result network spherical particles, due ability branched architecture freeze entanglements and bridge core domains. Small-angle X-ray scattering data promotes formation multicore...
Cyclic peptide–polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between cyclic peptides. In this study, we have engineered responsive introducing a cleavable bond that responds to reductant utilizing pyridyl disulfide reaction chemistry. Reactions cysteine containing peptide (CP-SH) and polymers were initially studied, leading quantitative formation conjugates. An asymmetric conjugate...
Supramolecular polymeric nanotubes based on the self-assembling cyclic peptide-polymer conjugates are a promising class of materials, showing great potential in various biological applications. Herein, we present novel strategy to promote nanotube assembly through effectively shielding peptides from water, via introduction varying hydrophobic groups. As determined by combination SANS, TEM, and SLS, interactions, π-π stacking, multiple hydrogen bonding interactions cooperate self-assembly...
Membrane models are widely used to mimic the behaviour of native plasma membranes and simulate interactions occurring at their interface. Such can be built up with different molecular compositions, ranging from single phospholipids more complex, heterogeneous mixtures phospho- sphingo-lipids, possibly enriched cholesterol proteins. In particular, mixing lipids is instrumental promote formation phase-separated, ordered domains, which resemble structure lipid rafts, specialized functional...
The E. coli Paraquat Inducible (Pqi) Pathway is a putative Gram-negative phospholipid transport system. pathway comprises three components: an integral inner membrane protein (PqiA), periplasmic spanning MCE family (PqiB) and outer lipoprotein (PqiC). Interactions between all complex components, including stoichiometry, remain uncharacterised; nevertheless, once assembled into their quaternary complex, the trio of Pqi proteins are anticipated to provide continuous channel membranes diderms....
This research addresses the growing menace of antibiotic resistance by exploring antimicrobial peptides (AMPs) as alternatives to conventional antibiotics. Specifically, we investigate two linear amphipathic AMPs, LE-53 (12-mer) and LE-55 (16-mer), finding that shorter exhibits greater bactericidal activity against both Gram-negative (G(-)) Gram-positive (G(+)) bacteria. Remarkably, AMPs are non-toxic eukaryotic cells. The heightened effectiveness is attributed its increased hydrophobicity...
Surface-tethered polymers have been shown to be an efficient lubrication strategy for boundary and mixed by providing a solvated film between solid surfaces. We assessed the performance of various graft copolymers as friction modifier additives in oil revealed important structure-property relationships this application. The consisted oil-soluble, grafted poly(lauryl acrylate) segment polar, linear poly(4-acryloylmorpholine) anchor group. Reversible addition-fragmentation chain transfer...
Over recent years, there has been a rapid development of membrane-mimetic systems to encapsulate and stabilize planar segments phospholipid bilayers in solution. One such system the use amphipathic copolymers solubilize lipid into nanodiscs. The attractiveness this system, part, stems from capability these polymers membrane proteins directly host cell membrane. assumption that native annulus remains intact, with nanodiscs providing snapshot environment. Recent studies have provided evidence...
Supramolecular copolymers are an emerging class of materials, which bring together different properties and functionalities multiple components via noncovalent interactions. While it is widely acknowledged that the repeating unit sequence plays essential role on performance these mastering tuning supramolecular copolymer still open challenge. To date, only statistical have been reported using cyclic peptide-polymer conjugates as building blocks. enrich diversity tubular copolymers, we report...