A5048524145- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Telomeres, Telomerase, and Senescence
- RNA regulation and disease
- Cognitive Science and Mapping
- Epigenetics and DNA Methylation
- Image Retrieval and Classification Techniques
- Regulation of Appetite and Obesity
- Congenital heart defects research
Sapienza University of Rome
2019-2024
Darwin Centre
2024
National Research Council
2015-2023
Institute of Cell Biology and Neurobiology
2015-2016
Boston Children's Hospital
2015-2016
Fondazione Santa Lucia
2015
Harvard University
2015
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutation of the X-linked MECP2 gene and characterized developmental regression during first few years life. The objective this study was to investigate if visual evoked potential (VEP) could be used as an unbiased, quantitative biomarker monitor brain function in RTT.We recorded pattern-reversal VEPs Mecp2 heterozygous female mice 34 girls with RTT. amplitudes latencies VEP waveform components were quantified, related disease...
Early life events have a crucial role in programming the individual phenotype and exposure to traumatic experiences during infancy can increase later risk for variety of neuropsychiatric conditions, including mood anxiety disorders. Animal models postnatal stress been developed rodents explore molecular mechanisms responsible observed short long lasting neurobiological effects such manipulations. The main aim this study was compare behavioral hormonal young adult animals exposed different...
Abstract The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry information from the hippocampus ventral striatum. However, possible cross-structural communication between these two brain regions in memory has thus far unknown. By selectively silencing subiculum–ventral striatum pathway we found that its activity after learning crucial consolidation and learning-induced plasticity. These results provide new...
Environmental enrichment has been proven to have positive effects on both behavioral and physiological phenotypes in rodent models of mental neurodevelopmental disorders. In this study, we used mice lacking the µ -opioid receptor gene ( Oprm1 −/− ), which shown deficits social competence communication, assess hypothesis that early can ameliorate sociability during development adulthood. Due immaturity sensory-motor capabilities young pups, chose as environmental stimulation a second...
It is a common belief that memories, over time, become progressively independent of the hippocampus and are gradually stored in cortical areas. This view mainly based on evidence showing prefrontal cortex (PFC) manipulations impair retrieval remote while hippocampal inhibition does not. More controversial whether activity medial PFC required immediately after learning to initiate consolidation. Another question concerns functional differences among subregions forming storing memories. To...
Training with long inter-session intervals, termed distributed training, has been known to be superior training short massed training. In the present study we compared c-Fos expression after and protocols in Morris water maze outline possible differences learning-induced pattern of neural activation dorsal CA1 two conditions. The results demonstrate that time lags between learning opportunities had an impact on neuronal activity CA1. Mice trained protocol showed sustained postero-distal...
SignificanceDistributed training has long been known to lead more robust memory formation as compared massed training. Using the water maze, a well-established task for assessing in laboratory rodents, we found that distributed and differentially engage dorsolateral dorsomedial striatum, optogenetic priming of striatum can artificially increase robustness level Overall, our findings demonstrate spatial consolidation engages different neural substrates depending on regimen, identifying...
Abstract Training with long inter-session intervals, termed distributed training , has been known to be superior short massed . In the present study we compared c-Fos expression after and protocols in Morris water maze outline possible differences learning-induced pattern of neural activation dorsalCA1 two conditions. The results demonstrate that time lags between learning opportunities had an impact on neuronal activity dorsalCA1. Mice trained protocol showed sustained postero-septal...
Abstract DNA damage is emerging as a driver of heart disease, although the cascade events, its timing, and cell types involved are yet to be fully clarified. In this context, implication cardiomyocytes has been highlighted, while that vasculature smooth muscle cells implicated but not explored exhaustively. our previous work we characterized factor called Ft1 in mice AKTIP humans whose depletion generates telomere instability damage. Herein, effect reduction on with goal comparatively...
It is a common believe that memories with time become progressively independent of the hippocampus and are gradually stored in cortical areas. This view mainly based on evidence demonstrating an impairing effect prefrontal cortex (PFC) manipulations retrieval remote paralleled by lack hippocampal inhibition. What more controversial whether activity mPFC required immediately after learning to initiate consolidation process. Further question possible functional differences among subregions PFC...
Abstract Distributed training has long been known to lead more robust memory formation as compared massed training. Here we demonstrate that distributed and differentially engage the dorsolateral dorsomedial striatum optogenetic priming of can artificially increase robustness level training, identifying a novel therapeutic avenue for enhancement.