A5009550060- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Dental Research and COVID-19
- Pharmacological Receptor Mechanisms and Effects
- Alzheimer's disease research and treatments
- Cholesterol and Lipid Metabolism
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Biosensors and Analytical Detection
- Pharmacological Effects and Assays
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 diagnosis using AI
- Mesenchymal stem cell research
- Bacillus and Francisella bacterial research
- Amyotrophic Lateral Sclerosis Research
- Medicinal Plants and Neuroprotection
- Neurological disorders and treatments
- Biotechnology and Related Fields
- Anesthesia and Neurotoxicity Research
- Biosimilars and Bioanalytical Methods
- Protein Kinase Regulation and GTPase Signaling
UCB Pharma (Belgium)
2011-2024
University of Bonn
2017
UCLouvain
2004-2005
Replacement of the lost myelin sheath is a therapeutic goal for treating demyelinating diseases central nervous system (CNS), such as multiple sclerosis (MS). The G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR) GPR17, which phylogenetically closely related to receptors "purinergic cluster," has emerged modulator CNS myelination. However, whether GPR17-mediated signaling positively or negatively regulates this critical process unresolved. We identified...
Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in clinic. Although results obtained Alzheimer's disease patients are compelling, discrimination tracer uptake healthy individuals and with supranuclear palsy (PSP) less clear as there substantial overlap signal multiple brain regions. Moreover, accurate quantification [18 F]AV-1451 may not be possible.The aim present study was to characterize vitro binding understand identify potential off-target that could explain poor...
Abstract Excitatory transmission in the CNS necessitates existence of dynamic controls glutamate uptake achieved by astrocytes, both physiological conditions and under pathological circumstances characterized gliosis. In this context, study was aimed at evaluating involvement group I metabotropic receptors (mGluR) regulation transport a model rat astrocytes undergoing vitro activation using cocktail growth factors (G5 supplement). The vast majority cells were found to take up aspartate,...
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective loss of motor neurones accompanied intense gliosis in lesioned areas the brain and spinal cord. Glutamate‐mediated excitotoxicity resulting from impaired astroglial uptake constitutes one current pathophysiological hypotheses explaining progression disease. In this study, we examined regulation glutamate transporters type 5 metabotropic receptor (mGluR5) activated astrocytes derived...
Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility receptor ligand pairs should be fundamental importance guide meaningful investigations into pharmacology and function individual receptors. GPR17 an characterized by some as dualistic uracil nucleotide/cysteinyl leukotriene others inactive toward these stimuli altogether. Whereas regulation...
[18F]T807 is currently being tested in humans as a tau positron emission tomography (PET) tracer. Described selectively binding to aggregates opposed Ab or a-synuclein aggregates, T807 was also reported be selective against 72 additional targets including MAO-A and MAO-B 1. [3H]T807 were characterized assays using recombinant proteins native tissues. We found that bound with nanomolar affinity on K18/K19 fibrils, human rat brain homogenates crude paired helical filaments (PHF) isolated from...
Summary IS 231 A was originally discovered in Bacillus thuringiensis as a typical 1.6 kb insertion sequence (IS) displaying 20 bp inverted repeats (IR) flanking transposase gene. first major variation of this canonical organization found MIC A1. This mobile cassette (MIC), delineated by A‐related extremities, contained an active d ‐stereospecific endopeptidase ( adp ) gene instead transposase. Interestingly, it shown that A1 can be mobilized trans the In paper, we show family –MIC elements...
Abstract Adult bone marrow mesenchymal stem cells are multipotent that can differentiate into a variety of mesodermal tissues. Recent studies have reported on their ability to also evolve non‐mesodermal cells, especially neural cells. While most these revealed manipulating triggers the expression typical neurone markers, less is known about induction neuronal‐ or glial‐related physiological properties. The present study focused characterisation glutamate transporters and activity in rat...
Abstract Since the onset of coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as National Reference Centre (NRC) for respiratory pathogens, to be first Belgian laboratory develop and implement developed diagnostic assays SARS-CoV-2 (severe acute syndrome 2) later assess quality commercial kits. To meet growing demand decentralised testing, both clinical laboratories government-supported high-throughput platforms were gradually deployed across Belgium....
Novel drug-like and selective Sigma-1 ligands have been prepared pharmacologically evaluated in a mouse model of cognitive deficits.
Something to ease the pain: Chemical modification of a 2-amino-oxazoline scaffold led identification α2C adrenergic receptor (AR) agonists. These ligands were characterized by dual α2C-AR agonist/α2A-AR antagonist profile. Structure–activity relationships studied, and screening in anesthetized rats demonstrated superior margin safety for this class compounds with respect cardiovascular effects compared nonselective α2-AR
Abstract Nasopharyngeal sampling has been the preferential collection method for SARS-CoV-2 diagnostics. Alternative procedures that are less invasive and do not require a healthcare professional would be more preferable patients health professionals. Saliva proposed as such possible alternative procedure. We evaluated sensitivity of testing on two different saliva devices (spitting versus swabbing) compared to nasopharyngeal swabs in over 2500 individuals were either symptomatic or had...
Selective leads: In this study, we generated a new series of serotonin 5-HT7 receptor antagonists. Their synthesis, structure–activity relationships, and selectivity profiles are reported. This includes antagonists with unprecedented high for the receptor, setting stage lead optimization drugs acting on range neurological targets. As service to our authors readers, journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized online delivery,...