A5024915367- Antifungal resistance and susceptibility
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Bacterial biofilms and quorum sensing
- Infection Control and Ventilation
- Antimicrobial Peptides and Activities
- Plasma Applications and Diagnostics
- interferon and immune responses
- Polymer Surface Interaction Studies
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Insect and Pesticide Research
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Endodontics and Root Canal Treatments
- COVID-19 and healthcare impacts
- Food Allergy and Anaphylaxis Research
- Nosocomial Infections in ICU
- T-cell and Retrovirus Studies
- Ocular Infections and Treatments
- Herbal Medicine Research Studies
Azienda Ospedaliero-Universitaria di Modena
2025
University of Modena and Reggio Emilia
2013-2024
University of Parma
2016
Candida causes an estimated half-billion cases of vulvovaginal candidiasis (VVC) every year. VVC is most commonly caused by albicans , which, in this setting, triggers nonprotective neutrophil infiltration, aggressive local inflammation, and symptomatic disease. Despite its prevalence, little known about the molecular mechanisms underpinning immunopathology fungal infection. In study, we describe determinant a potentially straightforward way to prevent response zinc limitation, C. releases...
Vulvovaginal candidiasis (VVC) is a common clinical condition with symptoms and signs of vaginal inflammation in the presence Candida species. At least one episode VVC experienced up to 75% women reproductive age group during their lifetime, 5% 8% such suffer from chronic form. Most cases are still caused by C. albicans. However, incidence non-albicans (NAC) species, as parapsilosis, continuously increasing. Despite prevalence NAC, little known about these species almost nothing mechanisms...
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for both acute and chronic infections in humans. In particular, its ability to form biofilm, on biotic abiotic surfaces, makes it particularly resistant host's immune defenses current antibiotic therapies as well. Innovative antimicrobial materials, like hydrogel, silver salts or nanoparticles have been used cover new generation catheters with promising results. Nevertheless, biofilm remains a major health problem. For...
Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality life. Although Candida albicans is a common commensal, it unknown if VVC results from switch commensal to pathogenic state, only some strains can cause VVC, and/or there displacement with more strains. We studied set colonizing C. identify consistent
Little is known about the complex events driving host–pathogen and pathogen–pathogen interplay in polymicrobial infections. Using an vitro model of a reconstituted vaginal epithelium (RVE) employing A-431 cell line supplemented with synthetic fluid (SVF), we studied consequences single versus dual infections Candida albicans and/or Herpes Simplex Virus-2 (HSV-2). Our data show (a) relevant, SVF-enhanced expression differentiation marker cytokeratin 5/6 RVE; (b) ability to enhance HSV-2...
In industrialized countries, health care associated infections, the fourth leading cause of disease, are a major issue. At least half all cases nosocomial infections with medical devices. Antibacterial coatings arise as an important approach to restrict infection rate without side effects and development antibiotic resistance. Beside clot formation affects cardiovascular devices central venous catheters implants. order reduce prevent such infection, we develop plasma-assisted process for...
<b><i>Background/Aims:</i></b> New antivirals are needed to supplement or replace currently used drugs. The aim of this study was evaluate the antiviral activity synthetic peptides derived from physiological proteins. <b><i>Methods:</i></b> Vero cell monolayers were infected with herpes simplex virus 1, vesicular stomatitis virus, adenovirus, and coxsackievirus B5 strains in presence different concentrations selected viral yield determined by...
Endodontic biofilm is a microbial community, enclosed in polymeric matrix of polysaccharide origin where are found pathogens, like bacteria and opportunistic fungi responsible for various endodontic pathologies. As clinical importance the fact, that extremely resistant to common intracanal irrigants, antimicrobial drugs host immune responses. The aim this study was evaluate vitro efficacy Cu/CaOH2-based paste, against fungi, such as Staphylococcus aureus, Pseudomonas aeruginosa Candida...
Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) infected macrophages are inhibited their anti-Candida effector function (b) Candida biofilm protects from inactivation. The present vitro study is aimed at testing the effects of on sensitivity to pharmacological physical stress, such as antiviral drugs (acyclovir foscarnet) laser UVA1 irradiation. We also investigated whether fungus growth pattern, either sessile or...
Vulvovaginal candidiasis (VVC) is primarily caused by Candida albicans and affects 75% of childbearing age women. Although C. can colonize asymptomatically, disease associated with an increased burden, a loss epithelial tolerance breakdown in vaginal microbiota homeostasis. VVC symptoms have been ascribed to powerful inflammatory response the infiltration non-protective neutrophils (PMN). Here, we compared immunological characteristics fluids cellular protein extracts obtained from 28 women...
Antimicrobial peptides represent a promising alternative to traditional drugs in relation cost, toxicity and, primarily, the growing problem of drug resistance. Here we report on activity against HSV-1 and HSV-2 previously described wide-spectrum synthetic decapeptide, Killer Peptide (KP). As determined by plaque reduction assays, treatment with KP at 100 μg/mL resulted viral yield titer 3.5 Logs for 4.1 HSV-2. Further evaluation antiviral focused early stages virus replicative cycle,...
Antimicrobial peptides represent a promising alternative to traditional drugs in relation cost, toxicity, and, primarily, the growing problem of drug resistance. Here, we report on activity against HSV-1 and HSV-2 previously described wide-spectrum synthetic decapeptide, Killer Peptide (KP). As determined by plaque reduction assays, treatment with KP at 100 μg/mL resulted viral yield titer 3.5 Logs for 4.1 HSV-2. Further evaluation antiviral focused early stages virus replicative cycle,...
This in vitro study was aimed to assess the efficacy of dry steam inactivating Human Coronavirus OC43 (HCoV-OC43) as surrogate SARS-CoV-2, Influenza Virus A/H1N1/WSN/33 and Echovirus 7 on stainless steel, polypropylene, cotton. The virus models were chosen basis their transmission route environmental resistance. Tests carried out under a laminar flow cabinet, where two panels each material contaminated with viral suspension. inocula left then untreated panel (control) collected by swabbing...
Viral infections can cause genital tract disorders (including abortion) in cows, and bovine herpesvirus 4 (BoHV-4) is often present endometritis-affected animals. A major problem with cattle uterine viral general, BoHV-4 particular, our limited understanding of the pathogenic role(s) that these play endometrium. similar lack knowledge holds for molecular mechanisms utilized, host cell pathways affected, by BoHV-4. To begin to fill gaps, we set up optimized conditions infection a pure...