A5049668513- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Pneumonia and Respiratory Infections
- Oral microbiology and periodontitis research
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Biosensing Techniques and Applications
- Bacterial Infections and Vaccines
- Oral health in cancer treatment
- Probiotics and Fermented Foods
- Plant Pathogens and Fungal Diseases
- Clostridium difficile and Clostridium perfringens research
- Proteoglycans and glycosaminoglycans research
- Endodontics and Root Canal Treatments
- Dermatological and COVID-19 studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Biomarkers in Disease Prognosis
- Parvovirus B19 Infection Studies
- Viral-associated cancers and disorders
- Parasite Biology and Host Interactions
- Environmental Toxicology and Ecotoxicology
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Family Business Performance and Succession
University of Modena and Reggio Emilia
2007-2018
University of Milan
2013-2015
Ospedale San Paolo
2014-2015
Oral microbiota consists of hundreds different species bacteria, fungi, protozoa and archaea, important for oral health. mycoses, mostly affecting mucosae, are mainly caused by the opportunistic pathogen Candida albicans. They become relevant in denture-wearers elderly people, diabetic patients, immunocompromised individuals. Differently, bacteria responsible other pathologies, such as dental caries, gingivitis periodontitis, which affect even immune-competent An appropriate hygiene can...
Results of recent molecular studies have provided evidence three distinct species within the Candida parapsilosis complex, namely parapsilosis, orthopsilosis and metapsilosis. While there are initial data pertaining to virulence these with respect reconstituted epidermal oral epithelial tissues, been no studies, as yet, on their interaction immune cells. Employing an in vitro infection model using microglial cells, we investigated pathogenetic potential different isolates each species. We...
The pathogenic yeast Cryptococcus neoformans has evolved several strategies to survive within phagocytes. Recently, it been demonstrated that upregulation of the ATP binding cassette transporter-encoding gene antifungal resistance 1 (AFR1) is important not only for determining C. fluconazole but also in influencing fungal virulence. In present study, we showed fluconazole-resistant AFR1-overexpressing mutant strain was sensitive microglia-mediated anticryptococcal activity, as compared with...
Cryptococcosis, caused by Cryptococcus neoformans , is an invasive infection often occurring in AIDS patients. Potent therapy against HIV, which includes protease inhibitors (PIs), has beneficial effects also on opportunistic infections pathogens such as C. and albicans . PIs inhibit growth of affecting the activity its aspartyl proteases. We identified, cloned sequenced a cDNA from encoding for putative (CnAP1), corresponding genomic region. The gene cnap1 codifies protein 505 aa, with...
Highly active antiretroviral therapy (HAART), that includes human immunodeficiency virus (HIV) protease inhibitors (PIs), has been remarkably efficacious including against some opportunistic infections. In this report we investigated the effect(s) of PI indinavir on activity by Cryptococcus neoformans, an fungal pathogen responsible for recurrent meningoencephalitis in AIDS patients. Indinavir was also tested potential effects other parameters, such as viability, growth ability and...
ABSTRACT We investigated the interplay occurring between pathogens in course of dual infections, using an vitro model which THP‐1 monocytic cell line is first infected with HSV‐1 and then exposed to Ca or Cn . These three share some pathogenic features: they cause opportunistic target macrophages are neurotropic. Here, we show that HSV‐1‐infected cells exhibited augmented phagocytosis against two fungi but reduced capability counteract fungal infection: better ingestion by monocytes was...
Recently, we showed that herpes simplex virus 1 (HSV-1)-infected monocytes have altered antifungal defences, in particular they show augmented phagocytosis of Candida albicans followed by a failure the intracellular killing ingested fungi. On basis these functional data, comparative studies were carried out on gene expression profile cells infected with HSV-1 and/or C. order to investigate molecular mechanisms underlying such virus-induced dysfunction. Affymetrix GeneChip technology was used...