A5058084165- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Synthesis and biological activity
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Antifungal resistance and susceptibility
- Polyomavirus and related diseases
- Quinazolinone synthesis and applications
- Antimicrobial Peptides and Activities
- Insect and Pesticide Research
- Bacterial biofilms and quorum sensing
- Proteoglycans and glycosaminoglycans research
- Antibiotic Resistance in Bacteria
- Synthesis and Biological Evaluation
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Infection Control and Ventilation
- Reproductive tract infections research
- Escherichia coli research studies
- Ocular Infections and Treatments
- Psidium guajava Extracts and Applications
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
University of Modena and Reggio Emilia
2009-2025
Azienda Ospedaliero-Universitaria di Modena
2015
Azienda Unita' Sanitaria Locale Di Modena
2007
Institute of Neuroimmunology of the Slovak Academy of Sciences
2003
National Institute of Neurological Disorders and Stroke
2000-2003
Children's National
2003
National Institutes of Health
2000-2001
Istituto Superiore di Sanità
1995
Ospedale Santa Maria
1994
Human herpesvirus-6 (HHV-6), a ubiquitous beta-herpesvirus, is the causative agent of roseola infantum and has been associated with number neurologic disorders including seizures, encephalitis/meningitis, multiple sclerosis. Although role HHV-6 in human CNS disease remains to be fully defined, studies have suggested that can site for persistent infection.To characterize extent distribution glial cells from surgical brain resections patients mesial temporal lobe epilepsy (MTLE).Brain samples...
The aim of this study was to examine the cytotoxicity and antibacterial effects a variety essential oils on major respiratory tract pathogens. 13 evaluated Vero cells. activity by Kirby Bauer paper method, minimum inhibitory bactericidal concentration against Streptococcus pyogenes, agalactiae, pneumoniae Klebsiella pneumoniae, Haemophilus influenzae, Staphylococcus aureus Stenotrophomonas maltophilia isolated from clinical specimens. antibiotic sensitivity these isolates examined. Some...
The frequency of human herpesvirus 6 (HHV-6) DNA was assessed in autopsy material from multiple sclerosis (MS) plaques and normal-appearing white matter (NAWM) brains persons with MS, healthy brains, other neurologic diseases. Specific areas formalin-fixed, paraffin-embedded brain tissue samples were isolated by laser microscope. extracted microdissected material, HHV-6 genomic sequences amplified nested polymerase chain reaction. We analyzed 44 NAWM 64 MS 13 patients 46 non-MS disorders, 41...
Vulvovaginal candidiasis (VVC) affects nearly 3/4 of women during their lifetime, and its symptoms seriously reduce quality life. Although Candida albicans is a common commensal, it unknown if VVC results from switch commensal to pathogenic state, only some strains can cause VVC, and/or there displacement with more strains. We studied set colonizing C. identify consistent
ABSTRACT Herpesvirus infections can frequently lead to acute inflammation, yet the mechanisms regulating this event remain poorly understood. In order determine some of immunological regulated by human herpesvirus infections, we studied gene expression profile lymphocytes infected with 6 (HHV-6) using a novel immunomicroarray. Our nylon-based immunomicroarray contained more than 1,150 immune response-related genes and was highly consistent between experiments. Experimentally, found that...
Abstract Background hyaluronic acid (HA), a non-sulphated glycosaminoglycan, is present in synovial fluid, vitreous humour serum and many connective tissues. Pharmaceutical preparations of HA are used clinical practice for wound healing, joint pain, kerato-conjunctivitis, asthma, mouth care, oesophageal-reflux, gastritis. Moreover, it as filler to counteract ageing facial lipoatrophy. Our study aims at investigating the vitro antiviral activity high molecular weight HA. Methods MTT test was...
Little is known about the complex events driving host–pathogen and pathogen–pathogen interplay in polymicrobial infections. Using an vitro model of a reconstituted vaginal epithelium (RVE) employing A-431 cell line supplemented with synthetic fluid (SVF), we studied consequences single versus dual infections Candida albicans and/or Herpes Simplex Virus-2 (HSV-2). Our data show (a) relevant, SVF-enhanced expression differentiation marker cytokeratin 5/6 RVE; (b) ability to enhance HSV-2...
Candida albicans is a commensal organism, commonly inhabiting mucosal surfaces of healthy individuals, as part the resident microbiota. However, in susceptible hosts, especially hospitalized and/or immunocompromised patients, it may cause wide range infections. The presence abiotic substrates, such central venous or urinary catheters, provides an additional niche for attachment and persistence, particularly via biofilm development. Furthermore, poorly to most antifungals, including azoles....
Abstract A viral isolate obtained from peripheral blood lymphocytes of an infant with a nonspecific febrile syndrome was identified as human herpes‐virus 7 (HHV‐7) on the basis PCR analysis its DMA one set primers specific for HHV‐7. The correlation HHV‐7 episode affecting is suggested. © 1995 Wiley‐Liss, Inc.
<b><i>Background/Aims:</i></b> New antivirals are needed to supplement or replace currently used drugs. The aim of this study was evaluate the antiviral activity synthetic peptides derived from physiological proteins. <b><i>Methods:</i></b> Vero cell monolayers were infected with herpes simplex virus 1, vesicular stomatitis virus, adenovirus, and coxsackievirus B5 strains in presence different concentrations selected viral yield determined by...
Pseudomonas aeruginosa is a Gram-negative nosocomial pathogen, often causative agent of severe device-related infections, given its great capacity to form biofilm. P. finely regulates the expression numerous virulence factors, including biofilm production, by Quorum Sensing (QS), cell-to-cell communication mechanism used many bacteria. Selective inhibition QS-controlled pathogenicity without affecting bacterial growth may represent novel promising strategy overcome well-known and widespread...
The association between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) is controversial. In fact, it difficult to establish a causative role of HHV-6, due the high prevalence latently infected individuals in healthy population. Therefore, presence virus sequences tissue biopsy does not support viral role, serological assays do show significant differences MS patients control populations. only gene expressed during latency U94/rep. we have developed assay for detection antibodies...
Virological studies were carried out on 3 to 36-month-old patients admitted the Children's Hospital of University Modena with febrile syndrome from September 1990 February 1991. tests for human herpesvirus-6 (HHV-6), Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex 1 (HSV-1), adenoviruses, parainfluenza viruses 1, 2 and 3, respiratory syncytial (RSV) influenza A B. Viral infections confirmed in 60.7% patients: 39.6% correlated HHV-6, 5.4% EBV, both HHV-6 1.8% HSV-1, CMV an...
A platinum(II) complex with the antiviral drug acyclovir was synthesized and its anticancer properties were investigated in comparison to those of cisplatin. The platinum-acyclovir maintained activity parent acyclovir, though showing a minor efficacy on molar basis (ID(50) = 7.85 1.02 muMu for cisplatin, respectively). As agent, markedly less potent than cisplatin mole-equivalent basis, but it as effective when equitoxic dosages administered vivo P388 leukaemia-bearing mice (%T/C 209 211...