A5035348351- Cardiac pacing and defibrillation studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Cell Adhesion Molecules Research
- Cardiac Arrhythmias and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Melanoma and MAPK Pathways
- Cardiovascular Syncope and Autonomic Disorders
- Pregnancy and preeclampsia studies
- Protein Kinase Regulation and GTPase Signaling
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Gastroesophageal reflux and treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Eosinophilic Esophagitis
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Aortic Disease and Treatment Approaches
- Frailty in Older Adults
- Pericarditis and Cardiac Tamponade
Unity Health System
2018-2023
Unity Hospital
2018-2023
Hamad Medical Corporation
2021
Rochester General Hospital
2020
Regional Health
2020
University of Rochester
1993-2018
University of Rochester Medical Center
2011
Ludwig Cancer Research
2004
Vrije Universiteit Amsterdam
2004
University College London
2004
Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, whereas laminar high stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) IL-1 stimulate expression endothelial cell (EC) genes that may promote atherosclerosis. TNF-α regulate gene ECs, part, by stimulating mitogen-activated protein kinases (MAPK), which phosphorylate transcription factors. We hypothesized steady inhibits cytokine-mediated activation MAPK EC....
c-Jun NH 2 -terminal kinase (JNK) is activated by a number of cellular stimuli including reactive oxygen species (ROS). Previous studies have demonstrated that fluid shear stress (flow) inhibits cytokine-induced JNK activation in endothelial cells (ECs). In the present study, we show ROS ECs and hypothesized flow ROS-induced via modulation protection systems against ROS. was 300 μmol/L hydrogen peroxide (H O ) bovine lung microvascular (BLMVECs) with peak at 60 minutes after stimulation...
Thrombin mediates changes in endothelial barrier function and increases permeability. A feature of thrombin-enhanced hyperpermeability is contraction cells (ECs), accompanied by formation focal adhesions (FAs). Recently, a G protein-coupled receptor kinase-interacting protein, GIT1, was shown to regulate FA disassembly. We hypothesized that GIT1 modulates thrombin-induced FAs. In human umbilical vein ECs (HUVECs), thrombin recruited FAs, where colocalized with FAK vinculin. Recruitment FAs...
Background— The G-protein–coupled receptor kinase interacting protein-1 (GIT1) is a multidomain scaffold protein that participates in many cellular functions including internalization, focal adhesion remodeling, and signaling by both receptors tyrosine receptors. However, there have been no vivo studies of GIT1 function to date. Methods Results— To determine essential vivo, we generated traditional knockout mouse. mice exhibited ≈60% perinatal mortality. Pathological examination showed the...
Background Delirium is associated with worse outcomes in critically ill patients. In the subset of patients myocardial infarction (MI), impact on clinical delirium not as well elucidated. Hypothesis increased mortality hospitalized for MI. Methods The study used data from National Inpatient Sample 2012 to 2014, Healthcare Cost and Utilization Project. We included discharges primary diagnosis MI using relevant International Classification Diseases, Ninth Revision, Clinical Modification codes....
Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, while laminar high stress are atheroprotective. Well characterized atheroprotective mechanisms include inhibition thrombosis (increased tissue-type plasminogen activator decreased inhibitor-1), endothelial cell apoptosis, limitation permeability (uptake low-density lipoprotein), prevention white blood binding transmigration (no expression adhesion molecules such as intercellular molecule-1 [ICAM-1]...
Inflammatory bowel diseases (IBD) associated-chronic inflammation and autonomic dysregulation may predispose to arrhythmias. However, its exact prevalence is unknown. Thus, we aimed ascertain the of arrhythmias in patients with IBD.We queried Nationwide Inpatient Sample (the largest publicly available all-payer inpatient USA database) from 2012 2014. We used International Classification Diseases, Ninth Revision, Clinical Modification (ICD-9 CM) discharge codes identify adult (⩾18 years) IBD...
Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data available regarding the disease arrhythmias.Data from National Inpatient Sample (NIS) database 2012-2014, were reviewed. Dis-charges identified as target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of tachycardia (VT) in population. Secondary outcomes include rate fibrillation (VF)...
The incidence of Lyme disease in the USA is 8 per 100 000 cases and 95% those occur Northeastern region. Cardiac involvement occurs only 1% untreated patients. We describe case a 46-year-old man who presented with chest pressure, dyspnoea, palpitations syncope. He initially atrial fibrillation rapid ventricular response, rare manifestation carditis. In another hospital presentation, he had varying degrees atrioventricular block including Mobitz I second-degree heart block. After appropriate...
Grid image refractometry (GIR) is proposed as a technique for determining the two-dimensional density profiles of long scale-length laser-produced plasmas. Its distinctive feature that an optical probe beam broken up into ‘‘rays’’ by being passed through grid before traversing plasma. The refraction angles rays are measured imaging plasma at two or more object planes and integrated to yield phase front. For cylindrically symmetric plasmas profile then determined using Abel inversion....
Myocardial infarction (MI) remains a leading cause of mortality. Palliative care (PC) has recently expanded in scope to include noncancer-related conditions. There is little data available regarding the use PC critical MI patients.We used discharge from National Inpatient Sample for years 2012 2014. We examined discharges with primary diagnosis MI. measured rate referral, trend utilization during study period and possible predictors utilization.Among 1 667 520 those patients ≥18 age MI, was...
Post-cardiac injury syndrome (PCIS) is presumed to be an immune-mediated process. It affects the pericardium and, a lesser extent, epicardium, myocardium, and pleura. has been rarely reported following pacemaker insertion with estimated incidence of 1% 2%. We present case 62-year-old female who developed PCIS 8 weeks insertion. She presented impending cardiac tamponade requiring pericardiocentesis; recurrent pleural effusions subsequently complicated her condition. The effusion recurred...
Cardiac myxoma is a benign neoplasm composed of stellate to plump, cytologically bland mesenchymal cells set in myxoid stroma. Although benign, as they can lead severe complications, are often removed surgically. A 39-year-old female presented with chief complaint generalized fatigue. Patient had history large 7cm x 2.5cm left atrial resected at the age 32 years after she symptoms dyspnea on exertion. The was due prolapse mass through mitral valve during diastole, leading functional...
Background: Aortic dissection is a critical condition often presenting with acute, severe chest pain and haemodynamic instability. Early diagnosis essential to mitigate the high mortality risk. Imaging modalities play pivotal role in diagnosing aortic conditions, but determining appropriate method can be challenging. Case description: We report an asymptomatic 55-year-old female undergoing transthoracic echocardiography (TTE) for mitral valve regurgitation surveillance. Incidentally,...
Notch1 is a critical regulator of cell fate, angiogenesis and cardiovascular development. Upon ligand (Delta Serrate/Jagged) binding, proteolytically cleaved by γ -secretase to generate the Notch intracellular domain (N1-ICD). N1-ICD translocates nucleus stimulate target gene expression. Recently it was shown that mediates vascular smooth muscle (VSMC) proliferation neointimal formation after injury. G-protein-coupled receptor-kinase-2 interacting protein 1 (GIT1), multi-domain scaffold...