A5090975337- Global Maternal and Child Health
- Antibiotic Use and Resistance
- Mosquito-borne diseases and control
- Malaria Research and Control
- Pneumonia and Respiratory Infections
- Data-Driven Disease Surveillance
- Child Nutrition and Water Access
- Clinical Reasoning and Diagnostic Skills
- Patient Satisfaction in Healthcare
- Sepsis Diagnosis and Treatment
- Parasites and Host Interactions
- SARS-CoV-2 detection and testing
- Global Health and Epidemiology
- Vaccine Coverage and Hesitancy
- Diverse Scientific Research Studies
- Obesity, Physical Activity, Diet
- Machine Learning in Healthcare
- Global Public Health Policies and Epidemiology
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical Economics and Policy
- Healthcare Systems and Reforms
- Respiratory viral infections research
- Birth, Development, and Health
- Genetics, Bioinformatics, and Biomedical Research
- Vector-borne infectious diseases
Institut de Recherche en Sciences de la Santé
2018-2024
Instituut voor Tropische Geneeskunde
2023-2024
UCLouvain
2023-2024
Jenner Institute
2022
Oxford BioMedica (United Kingdom)
2022
University of Oxford
2022
Novavax (Sweden)
2022
Serum Institute of India (India)
2022
Centre National de la Recherche Scientifique et Technologique
2019
Abstract Background To guide antibiotic stewardship interventions, understanding for what indications antibiotics are used is essential. Methods In rural Burkina Faso, we measured dispensing across all healthcare providers. From October 2021 to February 2022, surveyed patients in Nanoro district, following visits health centres (3), pharmacies (2), informal medicine vendors (5) and inpatients centres. We estimated prevalence of use the proportion Watch group by provider type clinical...
Abstract Background In low- and middle-income countries, the prevalence of antimicrobial resistance (AMR) is increasing. To control AMR, WHO recommends monitoring antibiotic use, in particular Watch antibiotics. These are critically important antibiotics, with restricted use because at risk becoming ineffective due to increasing AMR. We investigated pre-hospital rural Burkina Faso. Methods During 2016–2017, we collected data from patients aged > 3 months presenting severe acute fever...
Abstract Background Low- and middle-income countries face significant challenges in differentiating bacterial from viral causes of febrile illnesses, leading to inappropriate use antibiotics. This trial aimed evaluate the impact an intervention package comprising diagnostic tests, a algorithm, training-and-communication on antibiotic prescriptions clinical outcomes. Methods Patients aged 6 months 18 years with fever or history within past 7 days no focus, suspected respiratory tract...
Background: Stalled progress in controlling Plasmodium falciparum malaria highlights the need for an effective and deployable vaccine. RTS,S/AS01, most vaccine candidate to date, demonstrated 55·8% (97·5% confidence interval [CI], 51-60) efficacy over 12 months African children.Methods: We conducted a double-blind, randomised, controlled trial of low-dose circumsporozoite protein-based vaccine, R21, with two different doses adjuvant, Matrix-M™ (MM), children aged 5-17 Nanoro, Burkina Faso,...
Background: The global health transition is linked with an increased burden of non-communicable diseases cardiovascular leading the epidemic. In sub-Saharan Africa (SSA), prevalence obesity has during past decades and there a need to investigate associated driving factors. Burkina Faso remains low, especially in rural areas. this study we recruited middle-aged adults, as part larger on genetic environmental contributions cardiometabolic disease among Africans.Objectives: To distribution BMI...
Optimising antibiotic use is important to limit increasing resistance. In rural Burkina Faso, over-the-counter dispensing of antibiotics in community pharmacies and non-licensed medicine retail outlets facilitates self-medication. We investigated its extent, reasons patterns.In an exploratory mixed-method design conducted between October 2020 December 2021, this study first explored illness perceptions, the range healthcare providers communities, knowledge for seeking outside facilities....
We introduce the Antimicrobial Resistance Diagnostic Use Accelerator program, and articles in this Supplement, which cover program 3 sub-Saharan Africa countries.
Abstract Background In Sub-Saharan Africa (SSA), febrile illnesses remain a major public health problem in children. However, the persistence of hrp2 antigen and low sensitivity p LDH RDT negatively affect antimalarials antibiotics prescription practices. These limitations lead to poor management diseases antimicrobial resistance (AMR). To improve diagnosis these subsequent antimicrobials, it is hypothesized that implementation an algorithm including two-step malaria Pf HRP2/ supported by...
Purpose: In 2005, Burkina Faso changed its first-line treatment for uncomplicated malaria from chloroquine to artemisinin-based combination therapies (ACTs). Patient adherence ACTs regimen is a keystone achieve the expected therapeutic outcome and prevent emergence spread of parasite resistance. Eleven years after introduction in health system, this study aimed measure level patients rural settlement investigate determinants nonadherence. Patients methods: The was carried out at public...
Antimicrobial resistance (AMR) is a rising threat in low-resource settings, largely driven by transmission the community, outside health facilities. Inappropriate antibiotic use one of main modifiable drivers AMR. Its risk especially high poor resource with limited diagnostic and surveillance capacities, many informal medicine vendors determining community use. We hypothesise that to optimise use, Watch antibiotics (recommended only as first-choice for more severe clinical presentations or...
To assess the impact of an intervention package on prescription antibiotic and subsequently rate clinical recovery for non-severe acute febrile illnesses at primary health centers. Patients over 6 months age presenting to care centres with fever or history within past 7 days were randomized receive either constituted point-of-care tests including COVID-19 antigen tests, a diagnostic algorithm training communication packages, standard practice. The outcomes prescriptions Day 0 (D0) (D7)....
In this Viewpoint, the authors explore determinants of patients' prescription adherence behaviors as part FIND's Advancing Access to Diagnostic Innovation essential for Universal Health Coverage and AMR Prevention (ADIP) trials (ClinicalTrials.gov identifier: NCT04081051). Research findings from Burkina Faso, Ghana, Uganda show that basic knowledge understanding instructions are can be improved through better communication. However, there a range other factors influence adherence, some which...
Abstract Low birthweight (LBW) is a worldwide problem that particularly affects developing countries. However, limited information available on its magnitude in rural area of Burkina Faso. This study aimed to estimate the prevalence low and identify associated factors Nanoro health district. A secondary analysis data collected during cross-sectional survey was conducted assess demographic surveillance system (HDSS). Maternal characteristics extracted from antenatal care books or by...
Background Rapid Diagnostic Tests (RDTs) have become the cornerstone for management of malaria in many endemic settings, but their use is constrained several reasons: (i) persistent antigen (histidine-rich protein 2; HRP2) leading to false positive test results; (ii) hrp2 deletions negative Pf HRP2 and (iii) limited sensitivity with a detection threshold around 100 parasites/μl blood ( p LDH- HRP2-based) tests. Microscopy still gold standard diagnosis, allows species determination...
<h3>Background</h3> In low and middle incomes countries such as sub-Saharan Africa, the management of febrile diseases remains challenging given lack practical diagnostic tools to screen real cause fever limits malaria rapid tests. order improve in children under 5 years, this study has been conducted. <h3>Methods</h3> The was conducted at Field Station Sigle, set-up by Clinical Research Unit Nanoro. All patients from 6–59 months attending outpatient clinic health facility Bologho district...
Abstract Background. In sub-Saharan Africa, the intermittent preventive treatment of malaria in pregnancy using sulphadoxine pyrimethamine (IPTp-SP) strategy is recommended to limit adverse effects on birth outcomes. Ten year after IPTp-SP was adopted Burkina Faso, we assessed magnitude and maternal factors low birthweight (LBW) Nanoro. Methods . A secondary analysis data from a cross-sectional study carried out women who gave at Nanoro peripheral health centers binary multivariate logistic...
Abstract Background. In sub-Saharan Africa, the intermittent preventive treatment of malaria in pregnancy with sulphadoxine pyrimethamine (IPTp-SP) strategy is recommended to limit consequences on birth outcomes. Ten year after IPTp-SP was adopted Burkina Faso, we assessed magnitude low birthweight (LBW) and its maternal factors Nanoro. Methods . A secondary analysis data from a cross-sectional study carried out women who gave at Nanoro peripheral health centers using binary multivariate...
Abstract Background: Rapid Diagnostic Tests (RDTs) have become the cornerstone for management of malaria in many endemic settings. However, use RDTs diagnostic strategies is constrained several reasons: (i) persistent antigen (histidine-rich protein 2; HRP2) leading to false positive test results; (ii) hrp2 deletions negative Pf HRP2 and (iii) limited sensitivity with a detection threshold around 100 parasites/µl blood ( p LDH- HRP2-based) tests. Microscopy still gold standard diagnosis,...
Abstract • Background : In Sub-Saharan Africa (SSA), febrile illnesses remain a major public health problem in children. However, the persistence of hrp2 antigen and low sensitivity p LDH RDT negatively affect antimalarials antibiotics prescription practices. These limitations lead to poor management diseases antimicrobial resistance (AMR). To improve diagnosis these subsequent antimicrobials, it is hypothesized that implementation an algorithm including two-step malaria Pf HRP2/ supported...
The malaria parasite Plasmodium falciparum (Pf) can sequester in the placenta resulting low density of peripheral parasitemia and consequently false negative diagnosis (by microscopy) pregnant women. Moreover, use rapid diagnostic tests (RDTs) strategies, including those for detection a infection during pregnancy, is constrained by either persistent antigen (histidine-rich protein 2; HRP2) after successful treatment, leading to positive test results, or results as previously mentioned due...