A5051735421- Antibiotic Use and Resistance
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Pneumonia and Respiratory Infections
- Viral Infections and Outbreaks Research
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- ICT in Developing Communities
- Disaster Response and Management
- COVID-19 Pandemic Impacts
- Data-Driven Disease Surveillance
- COVID-19 diagnosis using AI
- Wikis in Education and Collaboration
- Social Media in Health Education
- Granular flow and fluidized beds
- Health Sciences Research and Education
- Salmonella and Campylobacter epidemiology
- COVID-19 and Mental Health
- Viral Infections and Vectors
- Malaria Research and Control
- Mosquito-borne diseases and control
- Innovative Approaches in Technology and Social Development
- Bacteriophages and microbial interactions
- COVID-19 Clinical Research Studies
Instituut voor Tropische Geneeskunde
2014-2025
University Medical Center Utrecht
2022-2025
Utrecht University
2022-2024
Oklahoma State University Center for Health Sciences
2023
Research Institute for Tropical Medicine
2020
European Centre for Disease Prevention and Control
2018-2019
Santé Publique France
2018
Gamal Abdel Nasser University of Conakry
2018
Chulalongkorn University
2016
Karolinska Institutet
2016
In 2017, the exacerbation of an ongoing countrywide cholera outbreak in Democratic Republic Congo resulted >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed characteristics epidemiology DRC on basis surveillance treatment center data for 2008-2017. The 2017 nationwide from 3 distinct mechanisms: considerable increases number cholera-endemic areas, so-called hot spots, around Great Lakes eastern DRC; recurrent outbreaks progressing downstream along River; spread...
Between December 2015 and July 2016, a yellow fever (YF) outbreak affected urban areas of Angola the Democratic Republic Congo (DRC). We described in DRC assessed accuracy YF case definition, to facilitate early diagnosis cases future outbreaks.In DRC, suspected infection was defined as jaundice within 2 weeks after acute onset confirmed by either IgM serology or PCR for viral RNA. used investigation hospital admission forms. Comparing clinical signs between discarded cases, we calculated...
Background Non-typhoidal Salmonella (NTS) are a major cause of bloodstream infection (BSI) in sub-Saharan Africa. This study aimed to assess its longitudinal evolution as BSI, serotype distribution and antibiotic resistance pattern Kisantu, DR Congo. Methods As part national surveillance network, blood cultures were sampled patients with suspected BSI admitted Kisantu referral hospital from 2015–2017. Blood worked-up according international standards. Results compared similar data 2007...
Abstract Background To guide antibiotic stewardship interventions, understanding for what indications antibiotics are used is essential. Methods In rural Burkina Faso, we measured dispensing across all healthcare providers. From October 2021 to February 2022, surveyed patients in Nanoro district, following visits health centres (3), pharmacies (2), informal medicine vendors (5) and inpatients centres. We estimated prevalence of use the proportion Watch group by provider type clinical...
Abstract Background In low- and middle-income countries, the prevalence of antimicrobial resistance (AMR) is increasing. To control AMR, WHO recommends monitoring antibiotic use, in particular Watch antibiotics. These are critically important antibiotics, with restricted use because at risk becoming ineffective due to increasing AMR. We investigated pre-hospital rural Burkina Faso. Methods During 2016–2017, we collected data from patients aged > 3 months presenting severe acute fever...
In the Democratic Republic of Congo and other low-resource countries, community-acquired pathogens are increasingly resistant to most locally available antibiotics. To guide efforts optimize antibiotic use limit resistance, we quantified healthcare provider-specific community-wide use.From household surveys, estimated monthly visit rates by provider. From exit prevalence, defined daily doses, access/watch/reserve distribution Combining both, rates.Of 88.7 (95% CI 81.9-95.4) visits per 1000...
Community-level antibiotic use contributes to antimicrobial resistance, but is rarely monitored as part of efforts optimize in low- and middle-income countries (LMICs). We investigated the 4 weeks before study inclusion for persistent fever.The NIDIAG-Fever (Neglected Infectious diseases DIAGnosis-Fever) aetiologies infections patients ≥5 years old with fever ≥1 week six healthcare facilities Cambodia, Democratic Republic Congo (DRC), Nepal, Sudan. In present nested cross-sectional study, we...
It is very exceptional that a new disease becomes true pandemic. Since its emergence in Wuhan, China, late 2019, SARS-CoV-2, the virus causes COVID-19, has spread to nearly all countries of world only few months. However, different countries, COVID-19 epidemic takes variable shapes and forms how it affects communities. Until now insights gained on have been largely dominated by epidemics lockdowns Europe, United States. But this variety global trajectories little described, analysed, or...
To evaluate the effect of physical distancing and school reopening in Brussels between August November 2020, we monitored changes number reported contacts per SARS-CoV-2 case associated transmission. The second COVID-19 pandemic wave was result increased social contact across all ages following reopening. Physical measures including closure bars restaurants, limiting close contacts, while primary secondary schools remained open, reduced mixing controlled
To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors with STEC HUS, compared O157 or other serogroups, France during 2013-16. was isolated from 153/521 (30%) reported HUS cases: 45 O80, 46 and 62 serogroups. Median ages were 1.1 years, 4.0 years 1.8 respectively. infected patients less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0.14 95%...
Optimising antibiotic use is important to limit increasing resistance. In rural Burkina Faso, over-the-counter dispensing of antibiotics in community pharmacies and non-licensed medicine retail outlets facilitates self-medication. We investigated its extent, reasons patterns.In an exploratory mixed-method design conducted between October 2020 December 2021, this study first explored illness perceptions, the range healthcare providers communities, knowledge for seeking outside facilities....
Surveillance of antimicrobial resistance among gram-negative bacteria (GNB) is critical importance, but data for Peru are not available. To fill this gap, a non-interventional hospital-based surveillance study was conducted in 15 hospitals across from July 2017 to October 2019. Consecutive unique blood culture isolates key GNB (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter spp.) recovered hospitalized patients were collected centralized susceptibility...
Abstract Background Infectious diseases account for the third most common cause of neonatal deaths. Globally, antibiotic resistance (ABR) has been increasingly challenging sepsis treatment, with 26 to 84% gram-negative bacteria resistant third-generation cephalosporins. In sub-Saharan Africa, limited evidence is available regarding microbiology and ABR. To our knowledge, no studies have assessed bacterial infections ABR in Central-African Republic (CAR). Therefore, this study aimed describe...
Abstract Background Reducing contacts is a cornerstone of containing SARS-CoV-2. We evaluated the effect physical distancing measures and school reopening on consequently SARS-CoV-2 transmission in Brussels, hotspot during second European wave. Methods Using case reports contact tracing data August-November 2020, we estimated changes age-specific number reported contacts. associated these trends with instantaneous reproduction R t transmission-events distinct intervention periods Brussels...
Non-cases are suspect Ebola Virus Disease (EVD) cases testing negative by EVD RT-PCR after admission to an Treatment Centre (ETC). Admitting non-cases ETC prompts concerns on case- and workload in the ETC, risk for nosocomial infection, delays diagnosis disease-specific treatment. We retrospectively analysed characteristics, outcomes determinants of death admitted Conakry Guinea between 03/2014 09/2015. Of 2362 suspects who underwent full confirmatory PCR testing, 1540 (65.2%) were...
Antimicrobial resistance (AMR) is a rising threat in low-resource settings, largely driven by transmission the community, outside health facilities. Inappropriate antibiotic use one of main modifiable drivers AMR. Its risk especially high poor resource with limited diagnostic and surveillance capacities, many informal medicine vendors determining community use. We hypothesise that to optimise use, Watch antibiotics (recommended only as first-choice for more severe clinical presentations or...
Despite the global threat of antimicrobial resistance (AMR), evidence on use and quality medicines at community level is limited, particularly in impoverished, rural areas where prevalence (bacterial) infections high. To better understand processes that drive vulnerability to AMR’ effects, this study aimed assess social factors underpinning access to–and of–medical products healthcare, among people from Raglai ethnic minority Ninh Thuan Province, Vietnam. We conducted ethnographic research...