A5057195344- Vibrio bacteria research studies
- COVID-19 epidemiological studies
- Aquaculture disease management and microbiota
- Salmonella and Campylobacter epidemiology
- Child Nutrition and Water Access
- Influenza Virus Research Studies
- Blood donation and transfusion practices
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
National Institute of Biomedical Research
2011-2024
Institut Supérieur de Technique Médicale
2024
Ministry of Public Health
2013-2015
In 2017, the exacerbation of an ongoing countrywide cholera outbreak in Democratic Republic Congo resulted >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed characteristics epidemiology DRC on basis surveillance treatment center data for 2008-2017. The 2017 nationwide from 3 distinct mechanisms: considerable increases number cholera-endemic areas, so-called hot spots, around Great Lakes eastern DRC; recurrent outbreaks progressing downstream along River; spread...
Abstract Africa’s Lake Tanganyika basin is a cholera hotspot. During 2001–2020, Vibrio cholerae O1 isolates obtained from the Democratic Republic of Congo side lake belonged to 2 5 clades AFR10 sublineage. One clade became predominant after acquiring parC mutation that decreased susceptibility ciprofloxacin.
Cholera burden in Africa remains unknown, often because of weak national surveillance systems. We analyzed data from the African Surveillance Network (www.africhol.org).During June 2011-December 2013, we conducted enhanced seven zones and four outbreak sites Togo, Democratic Republic Congo (DRC), Guinea, Uganda, Mozambique Cote d'Ivoire. All health facilities treating cholera cases were included. incidences calculated using culture-confirmed corrected for lack culture testing usually due to...
We analyzed 1,093 Vibrio cholerae isolates from the Democratic Republic of Congo during 1997-2012 and found increasing antimicrobial drug resistance over time. Our study also demonstrated that 2011-2012 epidemic was caused by an El Tor variant clonal complex with a single susceptibility profile.
Background Since cholera appeared in Africa during the 1970s, cases have been reported on continent every year. In Sub-Saharan Africa, outbreaks primarily cluster at certain hotspots including African Great Lakes Region and West Africa. Methodology/Principal Findings this study, we applied MLVA (Multi-Locus Variable Number Tandem Repeat Analysis) typing of 337 Vibrio cholerae isolates from recent epidemics Democratic Republic Congo (DRC), Zambia, Guinea Togo. We aimed to assess relationship...
During 2014, Africa reported more than half of the global suspected cholera cases. Based on data collected from seven countries in African Cholera Surveillance Network (Africhol), we assessed sensitivity, specificity, and positive negative predictive values clinical case definitions, including that recommended by World Health Organization (WHO) using culture confirmation as gold standard. The study was designed to assess results real-world field situations settings with recent outbreaks or...
We used standardized methodologies to characterize Vibrio cholerae O1 isolates from Guinea, Democratic Republic of the Congo (DRC), Togo, Côte d'Ivoire and Mozambique. investigated 257 human collected in 2010 2013. DRC serotyped Inaba, while other countries Ogawa. All were biotype El Tor positive for cholera toxin. showed multidrug resistance but lacked ciprofloxacin resistance. Antimicrobial susceptibility profiles varied between countries. In particular, profile Mozambique (East-Africa)...
ABSTRACT Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic been particularly severe on African continent. Here, we report long read-based genome sequences of six V. strains isolated Democratic Republic Congo between 2009 2012.
The Banalia health zone in the Democratic Republic of Congo reported a meningitis epidemic 2021 that evolved outside season. We assessed effects response.
Background Behavioural risk factors for cholera are well established in rural and semi-urban contexts, but not densely populated mega-cities Sub-Saharan Africa. In November 2017, a epidemic occurred Kinshasa, the Democratic Republic of Congo, where no outbreak had been recorded nearly decade. During this outbreak, we investigated context-specific an urban setting among population that is frequently exposed to cholera. Methodology/Principal findings We recruited 390 participants from three...
Cholera outbreaks in fragile settings are prone to rapid expansion. Case-area targeted interventions (CATIs) have been proposed as a and efficient response strategy halt or substantially reduce the size of small outbreaks. CATI aims deliver synergistic (eg, water, sanitation, hygiene interventions, vaccination, antibiotic chemoprophylaxis) households 100-250 m 'ring' around primary outbreak cases. We report on protocol for prospective observational study effectiveness CATI. Médecins Sans...
Le choléra est un problème important de santé publique dans nombreux pays en développement. La République démocratique du Congo fait régulièrement face aux épidémies avec profil endémo épidémique à l'Est et l'Ouest. surveillance biologique Démocratique a commencé en1997 ce jour. Les échantillons selles sont prélevés chez les patients répondant la définition cas, provenance différentes provinces Congo. Ils conservés le milieu " Carry Blair expédiés au Laboratoire l'Institut national recherche...
Abstract Background: Cholera is endemic in the Democratic Republic of Congo. Starting 2016, a cholera epidemic swept through country and November 2017 reached capital Kinshasa, which had not experienced outbreak for nearly decade. Behavioural risk factors are well established rural semi-urban contexts but densely populated mega-cities from Sub-Saharan Africa. Such information crucial to guide context-specific control measures. We seized Kinshasa as an opportunity investigate this urban...
Despite contributing to the large disease burden in West Africa, little is known about genomic epidemiology of Streptococcus pneumoniae which cause meningitis among children under 5 years old region. We analysed whole-genome sequencing data from 185 S . isolates recovered suspected paediatric cases as part World Health Organization (WHO) invasive bacterial diseases surveillance 2010 2016. The phylogeny was reconstructed, accessory genome similarity computed and antimicrobial-resistance...
Cholera remains the major public health problem in world. is endemic DRC especially its east part. In Kasai Oriental province, cholera epidemic area which registered cyclically with high case fatality rate. The last one 2018 started Mbuji-Mayi city but later affected whole province during 45 weeks 5854 total suspected cases including 277 deaths (CFR: 4.7%). Our main objective was to describe this outbreak focusing on higher CFR. We conducted quantitative descriptive study using data from...