A5086741199- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Sphingolipid Metabolism and Signaling
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Microwave-Assisted Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Quinazolinone synthesis and applications
- Lysosomal Storage Disorders Research
- Synthesis and Biological Evaluation
- Organic and Inorganic Chemical Reactions
- Axial and Atropisomeric Chirality Synthesis
- Neuroscience and Neuropharmacology Research
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Synthesis and biological activity
- HIV/AIDS drug development and treatment
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- Crystallography and molecular interactions
- Synthesis and Biological Activity
University of Pavol Jozef Šafárik
2007-2024
A stereoselective approach has been developed to the new sugar amino acid and potential potent turn mimic 5-O-(tert-butyldimethylsilyl)-3-deoxy-1,2-O- isopropylidene-3-methoxycarbonylamino-α-D-xylofuranose 3-C-carboxylic (12), via [3,3]-sigmatropic rearrangement of allylic thiocyanates (Z)-6 (E)-7, prepared from D-xylose. The synthesis a dipeptide 13 is also described.
C-Glycosyl-(S)- and (R)-alanines 12a 12b were synthesized from the known β-C-glycoside 1. The nitrogen function was introduced by aza-Claisen rearrangement of allylic thiocyanate 7, derived corresponding alcohol 6. absolute configuration newly created chiral carbon center (C-3) assigned X-ray diffraction analysis intermediate 3(S)-isothiocyanato-D-glycero-D-galacto-decose 8a.
A stereoselective approach toward 2-amino-1,3-propanediol 13 is described. This compound represents the key intermediate in total synthesis of (+)-myriocin 1, an inhibitor serine palmitoyltransferase (SPT). Moreover, synthon can be used for mycriocin analogues. moiety necessary their biological activity.