A5060714283- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Effects of Radiation Exposure
- Telomeres, Telomerase, and Senescence
- Palliative Care and End-of-Life Issues
- Patient-Provider Communication in Healthcare
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Oral health in cancer treatment
- Blood Coagulation and Thrombosis Mechanisms
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Hydrogen's biological and therapeutic effects
- Chemotherapy-related skin toxicity
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- Neutropenia and Cancer Infections
- Glutathione Transferases and Polymorphisms
Ryhov Hospital Jönköping
2015-2025
Länssjukhuset i Kalmar
2023
// Mohamed Ali Mosrati 1 , Annika Malmström 2 Malgorzata Lysiak Adam Krysztofiak Martin Hallbeck 3 Peter Milos 4 Anna-Lotta 5 Charlotte Bratthäll 6 Michael Strandéus 7 Marie Stenmark-Askmalm 8 Söderkvist Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden Advanced Home Care Pathology Neurosurgery Oncology Oncology, District Hospital, Kalmar, Ryhov Jönköping, Genetics Correspondence to: Mosrati, e-mail: mohamed.ali.mosrati@liu.se Keywords: TERT...
Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for treatment glioblastoma. Objective To evaluate efficacy and safety disulfiram copper as add-on to alkylating chemotherapy patients with recurrent Design, Setting, Participants This was a multicenter, open-label, randomized phase II/III clinical trial parallel group design. Patients were recruited at 7 study sites Sweden 2 Norway between January 2017 November...
Objectives To assess the incidence of neutropenia, febrile documented infection with neutropenia and fever associated early-stage breast cancer (BC) in a real-life setting. Methods A retrospective study that includes 88 women BC who received first dose Epirubicin plus Cyclophosphamide or without 5-Fluorouracil, county hospital Ryhov, Sweden. The patients were included continuously from May 2017 to November 2020 ≥18 years old. All data was collected form G-CSF prophylaxis checked ensure it...
Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There now independent preclinical data supports DSF as an anticancer agent, and experimental suggest copper may increase its anti-neoplastic properties. also some clinical evidence promising agent extracranial cancers. In glioblastoma, induced O
Objectives The median survival in glioblastoma (GBM) patients used to be less than 1 year. Surgical removal of the tumor with subsequent concomitant radiation/temozolomide (the Stupp regimen) has been shown prolong survival. protocol was implemented county Jönköping 2006. purpose this study examine if treatment prolonged overall survival, an unselected patient cohort histologically verified GBM. Material and Method This includes all from Jönköping, a diagnosis GBM January 2001 December 2012....
Abstract Purpose Glioma patients have poor prognosis. The amount of detail disease-related information wish to receive is not known. aim this study was explore glioma patients’ experiences and preferences regarding receiving on diagnosis Methods Semi-structured interviews were performed with diagnosed glioma. analysed by qualitative content analysis without predefined categories two independent coders. Results Ten women 15 men, newly grade II–IV glioma, age 25–76 years, interviewed....
Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked acute radiation (ARSR).One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. symptoms itching, burning irritation self-reported twice using the visual analogue scale. Assessments used Radiation Therapy Oncology Group scoring system reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis performed....
Background: Biological causes of sex disparity seen in the prevalence cancer, including glioblastoma (GBM), remain poorly understood. One considered aspects is involvement chromosomes, especially loss chromosome Y (LOY). Methods: Tumors from 105 isocitrate dehydrogenase (IDH) wild type male GBM patients were tested with droplet digital PCR for copy number changes ten genes on Y. Decreased gene expression, a proxy loss, was then analyzed 225 IDH derived TCGA and overall survival both cohorts...
We sought to analyse the androgen receptor (AR) in glioblastoma (GBM) due location of AR gene on chromosome X, often reported with shorter survival and higher prevalence GBM among males. Copy number (CN) mRNA expression were tested droplet digital PCR 91 fresh‐frozen samples 170 formalin‐fixed, paraffin‐embedded collected at Linköping University Hospital. The cohort was also subjected pyrosequencing methylation analysis 17 CpG sites promoter. Additionally, analysed Cancer Genome Atlas (TCGA)...
Abstract Background There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of adoptive cell-based immunotherapy. Methods Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, concomitant adjuvant temozolomide (TMZ) only, or RT TMZ addition Autologous Lymphoid Effector Cells Specific Against Tumor (ALECSAT)...
Independently of tumour and treatment modulation, the host immune response status plays an important role in clinical outcome patients with cancer. The influence single nucleotide polymorphisms (SNPs) adjuvant radiotherapy (RT) on systemic breast cancer was investigated. Materials Methods: Eighty-six female recovering from surgery were As a control cohort, 82 healthy blood donors used. Blood-based SNPs, plasma C-reactive protein (CRP), cytokines chemokines analyzed for this purpose. Results:...
Abstract BACKGROUND Although proton radiotherapy has been used in a large scale for quite some time, published data from trials confirming the safety of therapy are still scarce. Yet, there indications radiation induced contrast enhancement (RICE) being more common after than photon radiotherapy. MATERIAL AND METHODS Between August 2015 and 2020, adult patients receiving primary CNS tumours at Skandion clinic Sweden were invited to PRO-CNS, prospective multicentre observational cohort study....
BACKGROUND: Standard treatment for newly diagnosed glioblastoma (GBM) patients is surgery followed by radiotherapy (RT) and temozolomide (TMZ) given concomitant adjuvant. Tumor MGMT methylation status has been identified as predictive response to TMZ. Also other factors are believed influence TMZ effect. We examined the role of different single nucleotide variants (SNV:s) ABCB1, a transmembrane drug transporter, survival GBM receiving RT with PATIENTS AND METHODS: Genomic samples from who...
Introduction: Complete 1p19q co-deletion is a molecular marker with favorable prognostic and predictive value in oligodendrogliomas (ODG) together mutations IDH1/2 the most abundant alteration. Moreover, new WHO classification of tumors central nervous system emphasizes importance testing for diagnostic purposes. The commonly used methods detection are FISH, MLPA or microsatellite analysis. All burdened some flaws, instance susceptibility to subjective evaluation, complicated analysis...
Venous thromboembolic events (VTE) are common complications in patients with glioblastoma (GBM). Factor V Leiden (FVL) polymorphism (rs6025, c.1601 G>A) is a known risk factor for VTE, evaluated cancer associated thrombosis (CAT) different tumor types. Little about the role of this variant development CAT GBM. A cohort 116 GBM (73 males and 43 females) all treated concomitant temozolomide radiotherapy, were genotyped FVL using PCR- pyrosequencing. Of cohort, 40 diagnosed 76 without VTE....
Low grade glioma (LGG), especially oligodendroglioma (ODG), are known for their usually good response to radio- and chemotherapy relatively prognosis amongst glioma. LGG can stay indolent after initial surgery years, however many will eventually progress higher tumor, although the pace of progression differ greatly. Temozolomide administered resection has been shown promote a hypermutated recurrent however, not all patients receive postoperative chemotherapy. We investigated changes in...
Abstract BACKGROUND Apart from few exceptions, men are more likely to be diagnosed with cancer during their lifetime, including glioblastoma (GBM), but the gender-related differences in GBM poorly understood. Loss of chromosome Y (LOY) peripheral blood cells is associated physiological ageing, also disorders like cardiovascular disease, Alzheimer’s disease and different types. In this study, we determined deletions on tumor tissue male patients GBM, studied impact LOY survival. MATERIAL AND...
Abstract BACKGROUND The mRNA and protein expression of androgen receptor (AR) are upregulated in glioblastoma (GBM) studies show that use AR antagonists leads to apoptosis GBM cells vitro reduction tumor volume a mouse model. With increased prevalence among males, the role genetic alterations worth investigating, especially taking into account location on chromosome X possible sex differences associated with it. MATERIAL AND METHODS Copy number (CN) were tested droplet digital PCR 106 fresh...