A5025767030- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Quinazolinone synthesis and applications
- Trypanosoma species research and implications
- Essential Oils and Antimicrobial Activity
- HIV/AIDS drug development and treatment
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Research on Leishmaniasis Studies
- Synthesis of heterocyclic compounds
- Organic Chemistry Cycloaddition Reactions
- Infant Nutrition and Health
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Problem and Project Based Learning
- Veterinary Practice and Education Studies
- Crystallography and molecular interactions
- Tea Polyphenols and Effects
- Meat and Animal Product Quality
- Animal health and immunology
University of Zagreb
2014-2024
University of Split
2008
BACKGROUND Various studies have been conducted to evaluate the effect of phenolic compounds on production animals. Supplementation animal diets with phytogenic compounds, such as different essential oils and polyphenols, could improve productivity well chemical composition oxidative stability food derived from those RESULTS During trial, 80 male broilers Ross 308 strain were allocated four dietary groups: control three groups supplemented thymol, tannic acid gallic acid. Feed utilisation was...
In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized and characterized by NMR, MS, elemental analysis. These novel hybrids differ in the type of linker substituent on benzimidazole moiety. Their antiproliferative activities evaluated one non-tumor (MDCK1) seven selected tumor (CaCo-2, MCF-7, CCRF-CEM, Hut78, THP-1, Raji) cell lines MTT test flow cytometry The with different types linkers an unsubstituted ring,
Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a-7e, 8a-8e, and 9a-9e were designed synthesised with the aim of evaluating their anti-bacterial anti-trypanosomal activities DNA/RNA binding affinity. Results from evaluations antibiotic-resistant pathogenic bacteria revealed that both o-chlorophenyl-1,2,3-triazole N-isopropylamidine moieties in 8c led strong inhibitory activity against resistant Gram-positive bacteria,...
Chamomile, common yarrow and immortelle ethanolic extracts were chemically analysed with respect to phenolics. Twelve phenolic acids separated identified by HPLC-DAD the presence of rosmarinic acid was additionally confirmed LC-MS. Five methods applied for evaluation extracts' antioxidant properties (FRAP, DPPH, ABTS, chelating activity, Briggs-Rauscher reaction), while antibacterial activity tested against some major food-borne pathogens (Campylobacter coli, Escherichia Salmonella Infantis,...
Newly synthesized 7-chloro-4-aminoquinoline–benzimidazole hybrids were characterized by NMR and elemental analysis. Compounds tested for their effects on the growth of non-tumor cell line MRC-5 (human fetal lung fibroblasts) carcinoma (HeLa CaCo-2), leukemia, lymphoma (Hut78, THP-1, HL-60) lines. The obtained results, expressed as concentration at which 50% inhibition is achieved (IC50 value), show that compounds affect differently depending applied dose ranged from 0.2 to >100 µM). Also,...
The newly synthesized quinoline–benzimidazole hybrids containing two types of triazole-methyl-phenoxy linkers were characterized via NMR and elemental analysis. Additional derivatization was achieved by introducing bromine at the C-2 position phenoxy core. These novel tested for their effects on growth non-tumor cell line MRC-5 (human fetal lung fibroblasts), leukemia lymphoma lines: Hut78, THP-1 HL-60, carcinoma HeLa CaCo-2. results obtained, presented as concentration that achieves 50%...
A series of new aliphatic N-sulfonylamidino thymine derivatives containing nucleobase, N-sulfonyl and amidine pharmacophores in the structure were synthesized by Cu(I)-catalyzed threecomponent coupling 1-propargyl thymine, benzenesulfonyl azides amines or ammonium salts.Preliminary vitro antitumor screening (human cervix adenocarcinoma -HeLa leukemia cells -Jurkat) revealed promising activities N,N-diethyl-(2) N-4-cyanobenzyl-(6) 4-acetamidobenzenesulfonyl amidine.(doi: 10.
The reactivity of new biologically active thymine derivatives substituted with 2-(arylsulfonamidino)ethyl group at N1 and N3 position was investigated in the gas phase using CID experiments (ESI-MS/MS) by density functional theory (DFT) calculations. Both show similar chemistry negative mode a retro-Michael addition (Path A–) being most abundant reaction channel, which correlate well fluoride induced observed solution. difference fragmentation N-3 5 N-1 1 positive relates to preferred...
Trypanosoma cruzi is a hemoflagellated parasite causing Chagas disease, which affects 6–8 million people in the Americas. More than one hundred years after description of this available drugs for treating T . infection remain largely unsatisfactory. Chloroquinoline and arylamidine moieties are separately found various compounds reported their anti-trypanosoma activities. In work we evaluate anti- activity collection 26 “chimeric” molecules combining choroquinoline amidine structures. first...
Two novel series of N-sulfonylamidino pyrimidine derivatives were synthesized via Cu-catalyzed three-component reaction propargylated nucleobases with different benzenesulfonyl azides and amines.In this way 4-acetamido, 4-methyl 4-carboxybenzenesulfonyl amidine products 15-26 in the uracil 4-acetamidobenzenesulfonyl 27-29 cytosine prepared 34-69 % yields.Attempts to prepare 4-methylbenzenesulfonyl azide unsuccessful.The 32 33 from C4 triazole intermediates.The 1-28 tested for...
Shema 1 -Cu(I) katalizirana azid-alkinska cikloadicija Scheme catalysed azide-alkyne cycloaddition
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Vesna Rastija, Miroslav Bajić, Ivana Stolić, Luka Krstulović, Marijana Jukić, Ljubica Glavaš-Obrovac; QSAR analysis of antitumor activities 3,4-ethylenedioxythiphene derivatives. AIP Conf. Proc. 31 December 2015; 1702 (1): 190020. https://doi.org/10.1063/1.4938987 Download citation file: Ris (Zotero) Reference...