A5018188440- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Veterinary Pharmacology and Anesthesia
- Plasmonic and Surface Plasmon Research
- Metallic Glasses and Amorphous Alloys
- Anesthesia and Pain Management
- Advanced biosensing and bioanalysis techniques
- Urinary Bladder and Prostate Research
- Microstructure and mechanical properties
- Microbial Metabolic Engineering and Bioproduction
- Acupuncture Treatment Research Studies
- Menopause: Health Impacts and Treatments
- Tissue Engineering and Regenerative Medicine
- Identification and Quantification in Food
- Menstrual Health and Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nonlinear Optical Materials Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Mesenchymal stem cell research
- Amyotrophic Lateral Sclerosis Research
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Inflammatory mediators and NSAID effects
- Phase-change materials and chalcogenides
- Listeria monocytogenes in Food Safety
University of Illinois Urbana-Champaign
1996-2025
Zhejiang Provincial People's Hospital
2024
Illinois Department of Natural Resources
2023
University of Michigan
1998-2022
BioSurfaces (United States)
2019-2021
Colorado State University
2018
Texas A&M University
2018
East China University of Science and Technology
2008-2015
Peking University
2013-2014
University of Washington
2010-2013
Oxidative stress plays a key role in aging and related diseases, including neurodegeneration, cancer, organ failure. Copper (Cu), redox-active metal ion, generates reactive oxygen species (ROS), its dysregulation contributes to aging. Here, we develop activity-based imaging probes for the sensitive detection of Cu(I) show that labile hepatic Cu activity increases with age, paralleling decline ALDH1A1 activity, protective enzyme. We also observe an age-related decrease glutathione (GSH)...
A new method was developed to fabricate unique gold quasi-3D plasmonic nanostructures on poly(dimethylsiloxane) PDMS and 2D nanohole arrays silicon as surface-enhanced Raman scattering (SERS) substrates using electron beam lithography (EBL) with negative tone resist Ma–N 2403 soft lithography. The size shape of nanopillars fabricated by EBL were well controlled via different conditions. An enhancement factor (EF) high 6.4 × 105 obtained for 4-mercaptopyridine molecules adsorbed the...
The mechanical alloying process in the immiscible Ni–Ag system with a positive heat of mixing was investigated by x-ray diffraction and differential scanning calorimetry. High energy ball milling mixed elemental powders, nominal composition NixAg100−x (x=95, 90, 70, 50, 30), results formation mixtures supersaturated, nanocrystalline Ni-rich Ag-rich solid solutions. solubilities final grain sizes these phases depend on powder. maximum were determined using Vegard’s law to be 4.3 at. % Ni Ag...
Abstract Local electric fields can be tuned dramatically by varying the diameter of quasi‐3D gold plasmonic nanostructure arrays, as indicated 3D finite‐difference time‐domain calculations. Utilizing arrays that exhibit a maximum field intensity (i.e., “hot” spot) either at bottom (gold nanodisks) or on top film patterned with nanoholes), optimal surface‐enhanced Raman scattering (SERS) sensitivity for detection small molecules large microorganisms achieved. The precisely fabricated and...
The local electric field distribution and the effect of surface-enhanced Raman spectroscopy (SERS) were investigated on quasi-3D (Q3D) plasmonic nanostructures formed by gold nanohole nanodisc array layers physically separated a dielectric medium. fields at top nanoholes bottom nanodiscs as function medium, substrate, depth Q3D upon irradiation 785 nm laser calculated using three-dimensional finite-difference time-domain (3D-FDTD) method. intensity maximum was shown to oscillate with...
The outer membrane of a bacterium is composed chemical and biological components that carry specific molecular information related to strains, growth stages, expressions stimulation, maybe even geographic differences. In this work, we demonstrate the biochemical embedded in can be used for rapid detection identification pathogenic bacteria using surface-enhanced Raman spectroscopy (SERS). We seven different strains marine pathogen Vibrio parahaemolyticus as model system. represent four...
Light transmission and surface-enhanced Raman scattering (SERS) of quasi-3D plasmonic nanostructure arrays with deep (820 nm) shallow (80 Fabry-Pérot (FP) nanocavities were investigated experimentally by means 3D-finite-difference time-domain (3D-FDTD) simulations. The FP nanocavites exhibited the extraordinary optical strong SERS effect, whereas weaker light 6-time to one-order magnitude lower enhancement factors observed for those nanocavities. 3D-FDTD simulations revealed that electric...
Immunocompromised mouse strains expressing human transgenes are being increasingly used in biomedical research. The genetic modifications these mice cause various cellular responses, resulting histologic features unique to each strain. NSG-SGM3 strain is similar the commonly NSG (NOD scid gamma) but expresses encoding stem cell factor (also known as KIT ligand), granulocyte-macrophage colony-stimulating factor, and interleukin 3. This report describes 3 histopathologic seen when they...
A Raman spectroscopy-based approach was developed for the rapid determination of lactose in milk using crystal violet as an internal standard. The peak at 1173 reciprocal centimeters did not interfere with 1085 centimeters; therefore, can be used to quantify milk. This method allowed from 0.028–0.1 mole per liter, a limit detection 0.019 liter. results revealed that spectroscopy is simple and
Tomato (Lycopersicon esculentum Mill.) is one of the most important vegetable crops in China. In May 2011, root rot and plant wilt were observed on tomato plants (variety Jinguan No. 5 Meina) 26 commercial greenhouses Huludao city, Liaoning Province, Disease incidence was 30 to 95%. At beginning fruit set, symptoms chlorosis lower leaves lack turgidity young leaves. Severely affected wilted stunted as approached maturity. Primary secondary roots became necrotic with few fine feeder roots....
This work describes novel surface-enhanced Raman scattering (SERS) substrates based on ferroelectric periodically poled LiNbO3 templates. The templates comprise silver nanoparticles (AgNPs), the size and position of which are tailored by lithography. substrate has uniform large sampling areas that show SERS effective with excellent signal reproducibility, for fabrication protocol is advantageous in its simplicity. We demonstrate ferroelectric-based particle sizes ranging from 30 to 70 nm...
Although many surface-enhanced Raman scattering (SERS)-based methods for detecting specific proteins have been studied, simple and direct detection of total protein in liquid using a SERS-based method remains difficult. In this study, distinguishable effect on the SERS spectra from pre-mixture phosphomolybdic acid (PMA) with was found, indicating that PMA could be used as reporter sample. Further experiments confirmed good linear relationship between premixed concentration (casein, whey or...
Low-energy ball milling of amorphous Fe78B13Si9 has been performed at temperatures between 25 and 250 °C. Primary crystallization is observed after elevated temperatures, but not annealing the same temperatures. Although room temperature creates nucleation sites for primary crystallization, subsequent does result in significant crystallization. Heating by impact contamination tools during are ruled out as causes The behavior interpreted to be caused diffusivity enhancement due...
We recently demonstrated that intracellular xenogen-contaminated autologous MSCs (FBS) and non-xenogen-contaminated allogeneic (ALLO) caused an adverse clinical response after repeated intra-articular injection in horses, whereas (AUTO) did not. Our current objective was to use data from the previous study compare MSC stemness against indicated by synovial total nucleated cell count (TNCC) following injection.Stemness, quantified a trilineage differentiation (TLD) score; immunomodulation,...
Abstract Urodynamic studies, used to understand bladder function, diagnose disease, and develop treatments for dysfunctions, are ideally performed with awake subjects. However, in small medium-sized animal models, anesthesia is often required these procedures can be a research confounder. This study compared the effects of select survival agents (dexmedetomidine, alfaxalone, propofol) on urodynamic (Δpressure, capacity, compliance, non-voiding contractions, pressure slopes) anesthetic...
Abstract Background 1,3-Propanediol is the starting point of a new-generation polymer with superior properties which can be used in many industrial fields. 3-Hydroxypropionaldehyde and lactate have been identified as two important metabolites biological route 1,3-propanediol bioconversion from glycerol. Here, influence on inhibition caused by 3-hydroxypropionaldehyde fermentation Klebsiella pneumoniae reported. Methods The influences production were investigated normal pathway deficient...
Oxidative stress is one of the major culprits aging and age-related disease states. Although body features numerous antioxidant defense systems to safeguard against this, conditions ranging from neurodegeneration cancer organ failure may result once buffering capacity these protective mechanisms have been exceeded. While it known that redox active metal ions such as copper (Cu) can generate reactive oxygen species (ROS), establishing a possible connection between Cu dysregulation aging,...