A5063647963- Ion channel regulation and function
- Asthma and respiratory diseases
- Biochemical Analysis and Sensing Techniques
- Ion Channels and Receptors
- Respiratory and Cough-Related Research
- Arsenic contamination and mitigation
- Microbial Community Ecology and Physiology
- Epigenetics and DNA Methylation
- Advanced oxidation water treatment
- Signaling Pathways in Disease
- Constructed Wetlands for Wastewater Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive Biology and Fertility
- Cardiac electrophysiology and arrhythmias
- Environmental remediation with nanomaterials
- Neuroscience and Neuropharmacology Research
- Medicinal Plant Pharmacodynamics Research
- Herbal Medicine Research Studies
- Microbial metabolism and enzyme function
- Minerals Flotation and Separation Techniques
- Endoplasmic Reticulum Stress and Disease
- Soil and Water Nutrient Dynamics
- Berberine and alkaloids research
- Biological and pharmacological studies of plants
- Microbial Metabolism and Applications
State Ethnic Affairs Commission
2019-2025
Zunyi Medical University
2025
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Taizhou University
2023
South Central Minzu University
2014-2022
Huazhong Agricultural University
2020
Institute of Hydrobiology
2019
Chinese Academy of Sciences
2019
TU Dresden
2017
Intracellular Ca2+ release activated by inositol 1,4,5-trisphosphate (InsP3) plays a pivotal role in signaling cells. A controlling mechanism for InsP3-induced movements is suggested results showing that the InsP3-releasable pool directly modified specific and sensitive GTP-regulated Ca2+-translocating process. By using saponin-permeabilized N1E-115 neuroblastoma cells or DDT1MF-2 smooth muscle-derived cells, InsP3 releases 30-50% of accumulated through intracellular high-affinity...
Abuse of heavy metals and antibiotics results in the dissemination metal resistance genes (MRGs) antibiotic (ARGs). Ditch wetlands are important sinks for antibiotics. The relationships between bacterial communities MRG/ARG under dual stresses remain unclear. responses MRGs ARGs to co-selective pressure cadmium (Cd) doxycycline (DC) ditch were investigated after 7-day 84-day exposures. In ecological ditches, residual rates Cd DC varied from 0.4 –5.73% 0 –0.61%, respectively. greatest total...
The participation of large-conductance Ca2+ activated K+ channels (BKs) in chloroquine (chloro)-induced relaxation precontracted airway smooth muscle (ASM) is currently undefined. In this study we found that iberiotoxin (IbTx, a selective inhibitor BKs) and chloro both completely blocked spontaneous transient outward currents (STOCs) single mouse tracheal cells, which suggests might block BKs. We further inhibited sparks caffeine-induced global increases. Moreover, can directly BK from the...
Heat stress (HS), a nonspecific response to environmental heat, can seriously affect dairy cow health. Feed additives may alleviate HS in cows by improving rumen fermentation efficacy, stimulating feed consumption, enhancing vasodilation, and/or antioxidant capacity. The temperature–humidity index (THI) indicates that spring is non-HS season, and summer an season. results the decrease capacities. Our indicated superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total...
The aim of this study was to explore the applicability manganese coated sand (MCS) in presence and absence sodium hypochlorite for removal Mn(II) (2 mg/L) from aqueous solutions. Sand itself is widely used as a filter media treatment wastewaters it reported that during treatment, Mn(II), which present wastewater, be deposited on surface form dioxide. investigation dealt with various MCS samples, prepared laboratory by doses (i.e. 0.05 0.2 mol/L) samples were obtained pilot plant naturally...
Summary It has been reported that bitter tastants decrease blood pressure and relax precontracted vascular smooth muscle. However, the underlying mechanisms remain unclear. The aim of present study was to determine mechanism vasorelaxant effect tastants. Thoracic aortic rings were isolated from Wistar rats contractions measured using an isometric myograph. Intracellular Ca 2+ ([Ca ] i ) in single rat thoracic muscle cells recorded by calcium imaging. Calcium currents patch‐clamp techniques....
β2-adrenoceptor agonists are commonly used as bronchodilators to treat obstructive lung diseases such asthma and chronic pulmonary disease (COPD); however, they induce severe side effects. Therefore, developing new is essential. Herbal plants were extracted the extracts' effect on airway smooth muscle (ASM) precontraction was assessed. The ethyl alcohol extract of semen cassiae (EESC) from Semen cassia. effects EESC Ach- 80 mM K+-induced sustained in mouse human ASM evaluated. Ca2+ permeant...
Summary Azithromycin ( AZM ) has been used for the treatment of asthma and chronic obstructive pulmonary disease COPD ); however, effects underlying mechanisms remain largely unknown. The on airway smooth muscles ASM s) were studied using isometric muscle force measurements, examination lung slices, imaging, patch‐clamp techniques. completely inhibited acetylcholine ACH )‐induced precontraction s in animals (mice, guinea pigs, rabbits) humans. Two other macrolide antibiotics, roxithromycin...
Chloroquine, a bitter tastant, inhibits Ca2+ signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear. In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular increases mouse splenic primary lymphocytes, which were markedly inhibited by chloroquine. Under Ca2+-free conditions, TG elicited transient increases, additionally elevated upon restoration 2 mM Ca2+. The former from release store and latter influx....
The higher oxidation state of iron, i.e. Fe(VI), was exploited to treat the synthetic wastewater containing Zn(II)-NTA. decomposition Zn(II)-NTA by Fe(VI) investigated with help analytical data obtained for change in concentration, dissolved organic carbon (DOC) and total soluble Zn(II) concentration as a function time at various concentrations constant concentration. UV-Visible used explain reaction kinetics redox reactions between pseudo-first-order rate calculated keeping excess hence...
This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that had no effect on resting muscle tone In contrast, relaxed high K+-contracted mouse rings a dose-dependent manner inhibited both influx voltage-dependent L-type channel currents induced by K+. Similarly, also acetylcholine-induced contractions manner. Meanwhile, intracellular...
Plant communities in nature are often challenged by multiple global change factors (GCFs) and also ubiquitously encountered with soil nutrient heterogeneity. So far, however, we know little about the interactive effect of GCFs heterogeneity on plant communities. We conducted an outdoor mesocosm experiment which a community was either grown heterogeneous soils consisting high‐ low‐nutrient patches, or homogeneous where same amount nutrients evenly distributed. These were exposed to none...
Calcium signalling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and acrosome reactions are all mediated by increases in intracellular Ca2+. Our previous reports have shown that deficiency MTMR14, a novel phosphoinositide phosphatase, induces muscle disorder disrupting Ca2+ homeostasis. Recently, we found MTMR14 also expressed the testes; however, whether testes alters concentration impairs male fertility remains entirely unknown. present...
Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and widely used as an analgesic agent. Herein, we found that DCF could relax high K
The purpose of this study was to screen a bronchodilator from old drugs and elucidate the underlying mechanism. Paracetamol (acetaminophen) is widely used analgesic antipyretic drug. It has been reported that it inhibits generation prostaglandin histamine, which play roles in asthma. These findings led us explore whether paracetamol could be potential bronchodilator. inhibited high K+- acetylcholine (ACH)-induced precontraction mouse tracheal bronchial smooth muscles. Moreover, ACH-induced...
Abstract The aim of the present investigation is to assess applicability Fe(VI) in treatment simulated wastewater contaminated with Cd(II)–nitrilotriacetic acid (NTA) soluble species as a cleaner and greener technology. Initially, degradation NTA was observed single system reactor that applied varied doses NTA. Results were correlated change concentration measured by UV–visible spectrophotometer. As next step, introduced reaction containing Cd(II)–NTA investigate help total organic carbon...
Arbuscular mycorrhizal fungi (AMF) play important roles in terrestrial plants via mutualistic symbiosis. However, knowledge about the functions of AMF aquatic remains limited. Here, four dominate emergent plant communities West Lake, Hangzhou were chosen, characteristics AMF, C, N, and P stoichiometry, soil properties investigated. The results showed that both infection rates number spore species increased, suggesting a great mutualism between plants. Contents aboveground biomass roots their...
Summary The effects of hypertonic solution on airway smooth muscle ( ASM ) contraction and the underlying mechanisms are largely unknown. We found that saline HS inhibited acetylcholine AC h)‐induced from mouse trachea human bronchi. In single cells ASMC s), h induced an increase in intracellular Ca 2+ was further enhanced by 5% NaCl, indicating ‐induced inhibition not mediated a decrease cytosolic . Rho‐associated kinase ROCK inhibitor Y‐27632 relaxed h‐induced precontraction tracheal...
The SCUEC4 strain of Ochrobactrum intermedium is a newly isolated bacterium that degrades nicotine can use as the sole carbon source via series enzymatic catalytic processes. mechanisms underlying degradation in this and corresponding functional genes remain unclear. Here, we analyzed function biological properties ocnE gene involved nicotine-degradation pathways SCUEC4. was cloned by PCR with total DNA used to construct recombinant plasmid pET28a-ocnE. overexpression OcnE protein detected...