A5103064012- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Risk Factors
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Aortic and Vascular Conditions
- Cerebrovascular and Carotid Artery Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Immune cells in cancer
- Connective tissue disorders research
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Health and Disease Prevention
- Radiomics and Machine Learning in Medical Imaging
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Dialysis and Renal Disease Management
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
Weill Cornell Medicine
2017-2022
Cornell University
2015-2022
Presbyterian Hospital
2015-2020
NewYork–Presbyterian Hospital
2015-2018
New York Hospital Queens
2015-2018
Centro de Investigación Biomédica en Red
2015
Instituto de Investigaciones Biomédicas Sols-Morreale
2015
Instituto de Salud Carlos III
2015
Universidad Autónoma de Madrid
2015
Massachusetts General Hospital
2014
Objective— Although it is accepted that macrophage glycolysis upregulated under hypoxic conditions, not known whether this linked to a similar increase in proinflammatory activation and specific energy demands regulate cell viability the atheromatous plaque. Approach Results— We studied interplay between metabolism, polarization, context of atherosclerosis. Cultured human murine macrophages an vivo model atherosclerosis were used evaluate mechanisms underlying metabolic inflammatory activity...
<sup>18</sup>F-FDG accumulates in glycolytically active tissues and is known to concentrate that are rich activated macrophages. In this study, we tested the hypotheses human granulocyte-macrophage colony-stimulating factor (GM-CSF), a clinically used cytokine, increases macrophage glycolysis deoxyglucose uptake vitro acutely enhances within inflamed such as atherosclerotic plaques vivo. <b>Methods:</b> experiments were conducted on macrophages whereby inflammatory activation of radiolabeled...
Standard cine-cardiac magnetic resonance (CMR) imaging is commonly used to evaluate cardiac structure, geometry and function. Prior studies have shown that automated segmentation via partial voxel interpolation (PVI) accurately quantifies phantom-based chamber volumes necropsy left ventricular myocardial mass. Despite this, the applicability usefulness of PVI in determination physiologic parameters aorta such as aortic stiffness has yet be investigated.Routine CMR was conducted with a 1.5T...
Presentation of life-threatening arrhythmias concomitantly with a new-onset non-ischaemic cardiomyopathy raises concern for an inflammatory such as cardiac sarcoidosis or manifestations connective tissue disease. Comprehensive workup specific aetiologies may be unrevealing except signs myocardial inflammation identified on positron emission tomography (PET). Here, we present five cases subjects and their clinical course.We collected clinical, imaging, pathological, follow-up data presenting...
Methods Cine-CMR (SSFP) was performed on 1.5 Tesla (GE) scanners; pulse sequence parameters were equivalent to those for routine CMR (typical TR 3.4 msec, TE 1.14 flip angle 60, temporal resolution 30 msec). Images acquired in conventional cardiac (2, 3, 4 chamber) long axis or axial imaging planes. Aortic area uniformly measured a non-aneurysmal location within the mid-descending thoracic aorta: quantified via novel “partial voxel” segmentation algorithm (LV-METRIC) that accounts relative...
Introduction: Dyslipidemia is characterized by high levels of total cholesterol (TC), LDL (LDL-C), triglycerides (TG), or low HDL (HDL-C) and an established risk factor for subclinical clinical cardiovascular disease (CVD) among adults. Although several investigations exist in older American Indian (AI) adults, the data on AI adolescents young adults are scarce. Hypothesis: will be prevalent, incidence CVD higher with than without baseline dyslipidemia. Methods: We evaluated participants...