A5078997860- Diet and metabolism studies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Neuroscience of respiration and sleep
- Obesity, Physical Activity, Diet
- Metabolomics and Mass Spectrometry Studies
- Circadian rhythm and melatonin
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Diabetic Foot Ulcer Assessment and Management
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Colorectal and Anal Carcinomas
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
Iuliu Hațieganu University of Medicine and Pharmacy
2016-2025
Spitalul Clinic Județean de Urgență Cluj-Napoca
2022-2025
Clinical Emergency Hospital Bucharest
2021-2022
Clinical Research Consulting
2015-2016
County Hospital
2011
The aim of this analysis was to assess the costs associated with hospitalizations persons diabetes in a Romanian public hospital. We performed retrospective “top-down” cost all adult patients discharged from tertiary care hospital an ICD-10 primary or secondary code mellitus (type 1, type 2, specific forms) between 1 January 2015 and 31 December 2018. All were adjusted annual inflation rates converted EUR. included 16,868 28,055 episodes hospitalization. total hospitalization analyzed period...
Oxidative stress plays a key role in the development of chronic diabetes-related complications. Previous metabolomic studies showed positive association diabetes and insulin resistance with branched-chain amino acids (AAs) aromatic AAs. The purpose this research is to identify distinct metabolic changes associated increased oxidative stress, as assessed by nitrotyrosine levels, type 2 (T2DM). Serum samples 80 patients insulin-treated T2DM are analyzed AA-targeted metabolomics using...
Background/Objectives: Diabetic foot ulcers represent an important economic burden for healthcare systems worldwide. We aimed to analyze the costs of care diabetic (DFUs) associated with peripheral neuropathy (DPN) and arterial disease (PAD) their trends in a tertiary-care hospital. Methods: used data from electronic system Emergency Clinical County Hospital Cluj-Napoca, Romania. included all episodes hospitalization discharge date between 1 January 2015 31 December 2018 diagnosis type or 2...
Background/Objectives: Lifestyle factors, sociodemographic determinants, and dietary patterns play an important role in shaping genitors fetal health. This study aimed to identify investigate the social determinants of health lifestyle components associated with body mass index (BMI) a population reproductive age. Methods: A cross-sectional online survey was conducted between March 2021 February 2022. Self-reported data on age, weight, height, medical history were collected. Results: total...
Social jetlag (SJL) is a small recurrent circadian rhythm disruption and the most frequent form of misalignment. The main aim this study was to investigate effect SJL on glycemic control, as assessed by HbA1c, in real-life settings.In all, 115 consecutive patients with type 1 diabetes (T1D) were analyzed cross-sectionally. Data bedtime, sleep onset latency, wake up time weekdays weekends during previous month collected from all participants used calculate SJL, chronotype, duration. Sleep...
Inflammation along with coagulation disturbances has an essential role in the evolution towards a severe disease patients coronavirus 2019 (COVID-19). This study aimed to evaluate inflammatory and biomarkers when predicting need visit intensive care unit (ICU) diabetes mellitus (DM) patients. In retrospective study, laboratory parameters were examined for 366 participants: ICU = 90, of which 44 had DM no admittance 276. The ability markers distinguish severity COVID-19 was determined using...
Social jetlag (SJL) and, more recently, eating have been linked with an increased risk of non-communicable diseases. Here we aim to investigate lifestyle factors (diet, behavior, smoking, perceived stress, time spent sedentary/day) and social determinants (education level, employment status, place residence) associated SJL corrected for sleep duration (SJLsc) jetlag. Self-declared data on age, gender, lifestyle, behavior were collected online from March 2021 February 2022 432 adults....
The aim of the present study was to evaluate effect untreated sleep apnea syndrome (SAS) on glycemic control, evaluated by HbA1c, in patients with type 2 diabetes (T2D).The sample consisted 100 consecutive adult (≥18 years) T2D without a prior diagnosis recruited from an outpatient clinic. All underwent in-hospital cardiorespiratory using three-channel portable diagnostic tool; 64 were found have apnea, 36 not. Information medical history, body weight, height, symptoms, Epworth Sleepiness...
The chronic complications of diabetes mellitus (DM) are accompanied by inflammatory manifestations. Our study aimed to evaluate a possible association between the status (reflected serum chitotriosidase and neopterin) timely evolution occurrence microvascular in patients with type 1 DM. This observational, cross-sectional included 82 DM from Centre for Diabetes, Nutrition Metabolic Diseases, Cluj-Napoca, Romania. results demonstrated link extent inflammation, evaluated enzymatic activity...
This research aimed to explore the relation of social jetlag (SJL) with perceived appetite, and hormones involved in hunger regulation healthy subjects free-living conditions (study registration number: ACTRN12618001182280). Eighty normally diurnally active men women were enrolled 4 study groups according presence SJL sleep deprivation (2 or without deprivations 2 deprivation) matched 1:1:1:1 for age, gender, body mass index. Appetite was assessed fasting state, by measuring acylated ghrelin...
The objective of this cross-sectional analysis was to investigate in 109 adults with type 1 diabetes the relationship between sleep, circadian parameters and insulin sensitivity, as assessed by estimated glucose disposal rate (eGDR). In multiple regression only poor sleep quality duration were negatively associated eGDR (β = -0.219 [95%CI:-1.977; -0.445], p .002 for quality; β -0.183 [95%CI: -0.645; -0.111], .006 duration) independent age, gender, smoking status body mass index. conclusion,...
Lower extremity amputations (LEAs) are a burdensome complication of peripheral artery disease (PAD) and/or arterial embolism and thrombosis (AET). We assessed the trends in PAD- AET-related LEAs Romania.
Purpose: The objective of this study was to examine the association between insulin dose and high-sensitivity C-reactive protein (hsCRP), nitrotyrosine, pentraxin 3 in patients with insulin-treated type 2 diabetes. Patients methods: Eighty diabetes treated for >6 months stable doses (±10%) within before inclusion were enrolled study. Medical history, including use doses, concomitant diseases medication, anthropometric routine biochemical parameters collected each patient. hsCRP, measured...
The accuracy of prostate cancer local staging at the time diagnosis directly influences patient prognosis and treatment.To evaluate diagnostic performance interobserver variability mp-MRI in cancer, using histopathologic findings prostatectomy as reference standard.Fifty patients (mean age 64.4±7.2) with biopsy confirmed were included this prospective study. All examined before radical images read by three independent radiologists. Sensitivity (Se), specificity (Sp), positive predictive...
This study aimed to investigate gender differences in the relationship between ferritin levels and 25(OH)vitamin D deficiency overweight persons whether this is mediated by total visceral adiposity fatty liver index (FLI), a marker of non-alcoholic disease.Our was retrospective one which were collecting data from 92 patients seen an outpatient clinical centre January 2011 October 2017. Patients classified with vitamin if [ 20.0 ng/mL. Univariate linear regression analysis assessed...
To analyse the antidiabetic medication (ADM) market trends in Romania and to describe utilisation of new ADMs (glucagon-like peptide-1 receptor agonists [GLP-1 RA], dipeptidyl peptidase-4 inhibitors [DPP-4i] sodium-glucose transport protein 2 [SGLT-2i]).We conducted an analysis pharmacy claims data from IQVIA Romania. We analysed reimbursed prescriptions that included at least one ADM as defined daily doses (DDDs)/1000 inhabitants/day number prescriptions.The total DDDs/1000/day increased by...