A5003633015- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Plant Gene Expression Analysis
- Botanical Research and Applications
- Plant Stress Responses and Tolerance
- Phytochemicals and Antioxidant Activities
- Postharvest Quality and Shelf Life Management
- Fermentation and Sensory Analysis
- CAR-T cell therapy research
- Tea Polyphenols and Effects
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- Complement system in diseases
- Essential Oils and Antimicrobial Activity
- Endoplasmic Reticulum Stress and Disease
- Plant biochemistry and biosynthesis
- S100 Proteins and Annexins
- Synthesis and Biological Evaluation
- Viral Infectious Diseases and Gene Expression in Insects
- Medicinal Plants and Neuroprotection
- Pluripotent Stem Cells Research
- Light effects on plants
- Lung Cancer Research Studies
University of Pennsylvania
2006-2023
Agriculture and Food
2023
Seoul National University
2014-2022
University of California, Riverside
2021
Centre National de la Recherche Scientifique
1992
Institut Pasteur
1992
Rationale: Restoration of coronary artery blood flow is the most effective means ameliorating myocardial damage triggered by ischemic heart disease. However, reperfusion elicits an increment additional injury to myocardium. Accumulating evidence indicates that unfolded protein response (UPR) in cardiomyocytes activated ischemia/reperfusion (I/R) injury. Xbp1s (spliced X-box binding 1), highly conserved branch response, protective cardiac I/R GRP78 (78 kDa glucose-regulated protein), a master...
The composition of betalain, red or yellow pigments, and betaine (trimethylglycine glycinebetaine) nine beetroot ( Beta vulgaris L.) cultivars produced in the greenhouse field was studied. Inhibition HepG2 cell proliferation by betanin also tested. Four predominant betalains, two betacyanins (betanin isobetanin) betaxanthins (vulgaxanthin I miraxanthin V), were isolated quantified. Betanin vulgaxanthin major compounds extracts, respectively, they comprised >90% betalain content tested...
This study was carried out to better understand the mechanism responsible for increasing anthocyanins in blueberries after UV–B radiation at 6.0 kJ m–2 20 min. induced upregulation of genes involved anthocyanin biosynthesis blueberry fruit compared a nontreated control. Phenylalanine ammonia lyase, chalcone synthase, and flavanone 3′-hydroxylase, which are enzymes that function upstream biosynthesis, were significantly expressed by UV–B. Expression levels VcBBX, VcMYB21, VcR2R3MYB...
Ultraviolet (UV)-A, -B, and -C were radiated to full-ripe blueberries (cv. 'Duke'), their effects on fruit qualities phytonutrients during subsequent cold storage investigated. The exposed each UV light at 6 kJ/m(2) then stored 0 °C for 28 days. Weight loss decay of the fruits after treatment significantly decreased storage. total phenolics antioxidant activities UV-B treatments always higher than those control UV-A treatment. Individual anthocyanins markedly increased 3 h treatments....
Four tannin samples extracted from chestnut wood (tannin oenologique, TO), grape VR grape, TVG), oak gall galalcool, TG), and tree supra elegance, TE) were evaluated for antioxidant antibacterial activity. The highest total phenolic content (TPC) values observed in the order of TVG > TG TE TO (p < 0.05). activities all determined terms DPPH radical scavenging activity, reducing power, metal-chelating linoleic acid peroxidation assay. vary no correlation was with respective TPC each sample....
Human a1 -Microglobulin/Bikunin Gene Enhancer specific elements which strongly enhances transcription i n a tissue-specific manner.
Cytolytic effectors polarize toward target cells for effective killing and IFN-γ secretion. The spatiotemporal features of this polarization their importance cytolysis have not been resolved. In cytotoxic T natural killer (NK) cells, transient was consistently associated with killing. Polarization regulated by Cdc42, a small Rho family GTPase universally critical cytoskeletal dynamics. Transient accumulation active Cdc42 at the cytolytic effector/target cell interface focus such on center...
Activation of naïve T cells requires synergistic signals produced by the T-cell receptor (TCR) and CD28. We previously identified novel adaptor ALX, which, upon overexpression in Jurkat cells, inhibited activation interleukin-2 (IL-2) promoter TCR/CD28, suggesting that it is a negative regulator activation. To further understand physiological role ALX-deficient mice were generated. Purified from demonstrated increased IL-2 production, CD25 expression, proliferation response to TCR/CD28...
The herb holy basil (Ocimum tenuiflorum) is rich in essential oil, which important pharmaceutical, nutraceutical, cosmetic, and food industries. O. tenuiflorum grows well tropical, subtropical, warm temperate regions. To induce oil biosynthesis, plants were exposed to cold or drought stress for 5 days. Gas chromatography-mass spectrometry (GC–MS) analyses revealed that components including eugenol, methyl β-caryophyllene significantly accumulated 30-day-old juvenile 130-day-old pre-flowering...
Abstract Adaptors play a critical role in regulating signaling pathways that control lymphocyte development and activation. Adaptor lymphocytes of unknown function X (ALX) Rlk/Itk-binding protein (RIBP) are adaptors related by structure sequence, coexpressed T cells. Mice deficient for each adaptor demonstrated ALX RIBP, respectively, negatively positively regulate cell activation response to TCR/CD28 stimulation. However, these results did not preclude they may redundantly other...
Abstract The activation of T cells and the initiation an immune response is tightly controlled through crosstalk both positive negative regulators. Two adaptors that function as regulators cell are adaptor in lymphocytes unknown X (ALX) linker for (LAX). Previously, we showed from mice deficient ALX LAX display similar hyperresponsiveness, with increased IL-2 production proliferation upon TCR/CD28 stimulation, these physically associate. In this study, analyze nature association between LAX....
BACKGROUND: The sweetness of highbush blueberries is a sensory quality standard for consumers. Changes in metabolites and expression associated genes induce variation the blueberries. OBJECTIVE: This work investigated ripening mechanism by measuring changes organic acids sugar content as well gene levels with accumulation, such β amylase, invertase, sucrose phosphate synthase, tonoplast monosaccharide transporter genes, before after harvesting. METHODS: We used three different blueberry...
Abstract Parasitic nematodes cause significant morbidity and mortality globally. Excretory/secretory products (ESPs) such as fatty acid- retinol- binding proteins (FARs) are hypothesized to suppress host immunity during infection, yet little is known about their interactions with tissues. Leveraging the insect parasitic nematode, Steinernema carpocapsae , we provide first in vivo study that shows FARs modulate animal immunity, causing an increase susceptibility bacterial infection. Next...
BACKGROUND: The sweetness of highbush blueberries (Vaccinium corymbosum L.) is related to changes in sucrose and other primary sugar metabolites. OBJECTIVE: This study compared the fruit quality metabolism blueberry cultivars Brigitta Elizabeth at three ripening stages with a postharvest chitosan treatment determine which factors are important two cultivars. METHODS: Blueberries were harvested stages. Fully ripe was treated kept room temperature for 5 10 days. GC-MS used measure organic...
Abstract T cell development depends on the coordinated interplay between receptor signaling and transcriptional activation/repression. We performed a genetic complementation screen, identified novel repressor, NKAP. NKAP associates with HDAC3 is part of DNA-binding complex, as shown by chromatin immunoprecipitation. also CIR, Notch corepressor complex. The expression during inversely correlates target genes, implying that may modulate Notch-mediated transcription. To examine function in...
8042 Background: S100A9, a protein produced by myeloid-derived suppressor cells (MDSCs) in the bone marrow microenvironment, promotes multiple myeloma (MM) progression and confers therapeutic resistance. Tasquinimod (tasq), an oral S100A9 inhibitor, has pre-clinical anti-myeloma effects alone combined with proteasome inhibitor (PI) immunomodulator (Imid) therapy (Lin C, EHA 2020: EP896). Tasq previously improved PFS prostate cancer patients (pts) (JCO 2016;34(22):2636-43). We are conducting...
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are central immune effectors. They activate in a cellular interaction with target cells, leading to cell lysis IFN? secretion. These effector functions require effective polarization. We have therefore studied roles of Cdc42 Rac, two general regulators polarization, primary NK CTLs. were primed IL‐2, IL‐12/IL‐18, or IL‐15, reflecting different physiological therapeutically used activation conditions. expected that Cdc42/Rac by...