A5100352568- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Antioxidant Activity and Oxidative Stress
- Coconut Research and Applications
- RNA modifications and cancer
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Aquatic life and conservation
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
Hubei University of Chinese Medicine
2024
Hubei University of Science and Technology
2024
Ningxia Medical University
2023
Second Affiliated Hospital of Fujian Medical University
2022
Fujian Medical University
2022
Tangshan People's Hospital
2020-2021
Soochow University
2018
Abstract Background Hypercholesterolemia is found in patients with chronic lung inflammation, during which airway epithelial cells play important roles maintenance of inflammatory responses to pathogens. The present study aims at molecular mechanisms by cholesterol changes sensitivity response smoking. Methods Human bronchial (HBEs) were stimulated cigarette smoke extract (CSE) and mice exposed CS/lipopolysaccharide (LPS) as models vitro vivo. Severe COPD healthy volunteers also enrolled the...
Excessive neovascularization of atherosclerotic lesions increases plaque vulnerability and the susceptibility to rupture. Semaphorin 7A (Sema7A), a semaphorin family member, was recently reported promote formation by mediating d-flow-induced endothelial phenotypic change leukocyte adhesion. To extend our understanding proatherogenic role Sema7A, we investigated Sema7A in angiogenesis neovascularization. overexpression human umbilical vein cells (HUVECs) significantly upregulated VEGFA/VEGFR2...
Clear cell renal carcinoma (ccRCC) is the most common subtype of carcinoma. Cancer-associated fibroblasts (CAFs) as primary components cancer stroma can affect tumor progression by secreting exosomes, while exosomes are carriers for proteins, nucleic acids, and other agents that responsible delivery biological information. Given this, derived from CAFs emerging promising biomarkers in clinical diagnosis. Nevertheless, their role clear remains poorly understood.Here, we separated ccRCC...
Clear cell renal carcinoma (ccRCC) is a subtype of cancer with the highest mortality, infiltration, and metastasis rate, threatening human health. Despite oncogenic role TROAP in various cancers, its function ccRCC remains to be unraveled. The differentially expressed mRNAs (DEmRNAs) miRNAs (DEmiRNAs) were obtained by analyzing related data sets TCGA. expression levels detected qRT-PCR, while protein characterized western blot. viability, migratory invasive abilities cells determined MTT,...
Currently, there have been few studies on the function and molecular mechanism of miR-141-3p in development clear cell renal carcinoma (CCRCC). This study aimed to explore relationship between NIMA (never mitosis, gene A)-related kinase-6 (NEK6) investigate role interaction CCRCC proliferation, migration, invasion apoptosis.Starbase database was used predict target dual-luciferase reporter assay performed verify targeting gene. Real-time quantitative PCR conducted detect expression NEK6 mRNA...
Abstract Objective Our study aims to investigate the mechanism of miR-129-5p/SPN axis in clear cell renal carcinoma (ccRCC), providing a novel direction for targeted therapy ccRCC. Methods Bioinformatics methods were implemented find differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed detect miR-129-5p and SPN mRNA expression, while western bot carried out detection protein expression SPN. analysis used predict binding sites on 3’UTR,...
A number of studies reported that miR-224-5p is involved in a variety cancer-related cellular processes, yet its physiological role clear cell renal carcinoma (ccRCC) remains unclear. In order to clarify the function ccRCC, real-time quantitative-PCR was conducted compare expression human normal tubular epithelial lines and ccRCC first, strikingly upregulated observed lines. Inhibition by microRNA inhibitors could inhibit proliferation, migration, invasion cells. Besides, it validated...
Abstract Objective: Our study aims to investigate the mechanism of miR-129-5p/SPN axis in clear cell renal carcinoma (ccRCC), providing a novel direction for targeted therapy ccRCC. Methods: Bioinformatics methods were implemented find differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed detect miR-129-5p and SPN mRNA expression, while western bot carried out detection protein expression SPN. analysis used predict binding sites on 3’UTR,...
Abstract Objective: Our study aims to investigate the mechanism of miR-129-5p/SPN axis in clear cell renal carcinoma (ccRCC), providing a novel direction for targeted therapy ccRCC. Methods: Bioinformatics methods were implemented find differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed detect miR-129-5p and SPN mRNA expression, while western bot carried out detection protein expression SPN. analysis used predict binding sites on 3’UTR,...
Abstract Objective: Our study aims to investigate the mechanism of miR-129-5p/SPN axis in clear cell renal carcinoma (ccRCC), providing a novel direction for targeted therapy ccRCC. Methods: Bioinformatics methods were implemented find differentially expressed genes (DEGs) associated with ccRCC from TCGA database. qRT-PCR was performed detect miR-129-5p and SPN mRNA expression, while western bot carried out detection protein expression SPN. analysis used predict binding sites on 3’UTR,...