A5084024762- CRISPR and Genetic Engineering
- Wheat and Barley Genetics and Pathology
- Innovation and Socioeconomic Development
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Viral Infections and Immunology Research
- Neonatal Respiratory Health Research
- Food composition and properties
- Chromosomal and Genetic Variations
- Congenital Diaphragmatic Hernia Studies
- Plant Pathogens and Fungal Diseases
- Animal Genetics and Reproduction
- Liver Diseases and Immunity
- Virus-based gene therapy research
- Biofuel production and bioconversion
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Plant Disease Resistance and Genetics
- Diabetes and associated disorders
- Phytase and its Applications
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Animal Disease Management and Epidemiology
Shanghai Medical College of Fudan University
2019-2025
Zhongshan Hospital
2019-2025
Wenzhou Medical University
2022-2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Zhejiang University
2023
Henan Agricultural University
2021-2023
Shanghai Clinical Research Center
2022
Jinshan Hospital of Fudan University
2022
Fudan University
2020
Abstract Rye is a valuable food and forage crop, an important genetic resource for wheat triticale improvement indispensable material efficient comparative genomic studies in grasses. Here, we sequenced the genome of Weining rye, elite Chinese rye variety. The assembled contigs (7.74 Gb) accounted 98.47% estimated size (7.86 Gb), with 93.67% (7.25 assigned to seven chromosomes. Repetitive elements constituted 90.31% genome. Compared previously Triticeae genomes, Daniela , Sumaya Sumana...
Abstract Background Hypercholesterolemia is found in patients with chronic lung inflammation, during which airway epithelial cells play important roles maintenance of inflammatory responses to pathogens. The present study aims at molecular mechanisms by cholesterol changes sensitivity response smoking. Methods Human bronchial (HBEs) were stimulated cigarette smoke extract (CSE) and mice exposed CS/lipopolysaccharide (LPS) as models vitro vivo. Severe COPD healthy volunteers also enrolled the...
Autophagy related genes (ATGs) play essential roles in maintaining cellular functions, although biological and pathological alterations of ATG phenotypes remain poorly understood. To address this knowledge gap, we utilized the single-cell sequencing technology to elucidate transcriptomic atlas ATGs lung diseases, with a focus on epithelium lymphocytes. This study conducted comprehensive investigation into RNA profiles tissues obtained from healthy subjects patients different diseases through...
The African swine fever virus (ASFV) is a highly infectious viral pathogen that presents major threat to the global pig industry. No effective vaccine available for virus. p54 protein, structural component of ASFV, involved in adsorption and entry target cells also plays key role ASFV development disease prevention. Here, we generated species-specific monoclonal antibodies (mAbs), namely 7G10A7F7, 6E8G8E1, 6C3A6D12, 8D10C12C8 (subtype IgG1/kappa type), against protein characterized...
Fusarium head blight (FHB), elicited mainly by the fungal pathogen graminearum (Fg), causes serious damages to global wheat production. Development of resistant cultivars is most efficient measure for controlling FHB, which requires identification and utilization germplasm carrying FHB resistance genes. Because Fhb1 gene recently cloned from Sumai 3 Wangshuibai, designated here as Fhb1-R, confers type II we investigated presence Fhb1-R in 3,177 accessions different countries world. By PCR...
Barley malt is produced through a malting process; it begins with steeping followed by germination and kilning, in which dramatic changes happen for large number of physiological biochemical traits barley seeds. The objectives this study were to comprehensively investigate the phenotypic during malting, identify key regulators that modulate expression genes associated quality traits. results showed there was significant positive correlation between gibberellic acid (GA) content activities...
One-third of patients with autoimmune hepatitis (AIH) have cirrhosis at the time diagnosis. The relevance these variables, although unknown, is believed to be critical in AIH because suspected interactions between gut microbiome and genetic factors. Dysbiosis flora elevated polymeric immunoglobulin receptor (pIgR) levels been observed both mouse models. Moreover, there a direct relationship pIgR expression transaminase AIH. In this study, we aimed explore how influences secretion...