A5016768358- Barrier Structure and Function Studies
- Epilepsy research and treatment
- Diabetes Treatment and Management
- Diabetes Management and Research
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Caveolin-1 and cellular processes
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic function and diabetes
- Chronic Disease Management Strategies
- Cardiovascular Disease and Adiposity
- Thyroid Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Healthcare Policy and Management
- Global Health Care Issues
- Multiple and Secondary Primary Cancers
- Eosinophilic Disorders and Syndromes
- Ginkgo biloba and Cashew Applications
- Liver Disease Diagnosis and Treatment
- Head and Neck Anomalies
- Intraperitoneal and Appendiceal Malignancies
University of California, Berkeley
2019-2024
Integra (United States)
2024
Ben-Gurion University of the Negev
2024
Dalhousie University
2024
Missouri State University
2024
University of Oxford
2013-2021
Oxford Centre for Diabetes, Endocrinology and Metabolism
2017-2020
Saint Louis University
2018
Baylor College of Medicine
2013-2014
Aging involves a decline in neural function that contributes to cognitive impairment and disease. However, the mechanisms underlying transition from young-and-healthy aged-and-dysfunctional brain are not well understood. Here, we report breakdown of vascular blood-brain barrier (BBB) aging humans rodents, which begins as early middle age progresses end life span. Gain-of-function loss-of-function manipulations show this BBB dysfunction triggers hyperactivation transforming growth factor-β...
Knowledge of the normal and abnormal imaging appearances thyroid gland is essential for appropriate identification diagnosis lesions. Thyroid nodules are often detected incidentally at computed tomography, magnetic resonance imaging, positron emission tomography; however, ultrasonography (US) most commonly used modality characterization these nodules. US characteristics that increase likelihood malignancy in a nodule include microcalcifications, solid composition, central vascularity....
Increases in serum calcitonin, a tumor marker for medullary thyroid carcinoma (MTC), have been associated with glucagon-like peptide 1 receptor agonist use some preclinical studies. We report calcitonin changes exenatide-treated and placebo-administered participants MTC incidence the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) consider impact within-trial monitoring.EXSCEL were randomized 1:1 to once-weekly exenatide 2 mg or placebo. Serum was measured at baseline (with trial...
Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local network...
EXSCEL (Exenatide Study of Cardiovascular Event Lowering) assessed the impact once-weekly exenatide 2 mg versus placebo in patients with type diabetes mellitus, while aiming for glycemic equipoise. Consequently, greater drop-in open-label glucose-lowering medications occurred group. Accordingly, we explored potential effects their unbalanced use on major adverse cardiovascular events (MACE), defined as death, nonfatal myocardial infarction or stroke, and all-cause mortality (ACM), given that...
Structural uncertainty can affect model-based economic simulation estimates and study conclusions. Unfortunately, unlike parameter uncertainty, relatively little is known about its magnitude of impact on life-years (LYs) quality-adjusted (QALYs) in modeling diabetes. We leveraged the Mount Hood Diabetes Challenge Network, a biennial conference attended by international diabetes groups, to assess structural simulating QALYs type 2 models.Eleven groups participated 9th Challenge. Modeling...
OBJECTIVE To estimate using the UK Prospective Diabetes Study Outcomes Model Version 2 (UKPDS-OM2) impact of delaying type diabetes onset on costs and quality-adjusted life expectancy trial participants who developed in NAVIGATOR (Nateglinide And Valsartan Impaired Glucose Tolerance Research) study. RESEARCH DESIGN AND METHODS We simulated by 1–9 years, utilizing data from 3,058 9,306 diabetes. Costs utility weights associated with diabetes-related complications were obtained for U.S. U.K....
FNA of T‐lymphoblastic lymphoma associated FGFR1 rearranged MPN Diagn. Cytopathol. 2014;42:45–48. © 2013 Wiley Periodicals, Inc.
We report a case of synchronous primary colonic adenocarcinoma and malignant mesothelioma. A 61-year-old male presented with six-month history fatigue weight loss. An abdominal computed tomography (CT) scan showed 5.8 cm partially obstructing mass in the cecum ascites peritoneal thickening. biopsy large an adenocarcinoma. Because patient was clinically thought to be T4 colon carcinoma metastatic lesions (M1), prior initiating chemotherapy, debulking right hemicolectomy performed. Resection...
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local network...
The protein misfolding and aggregation of alpha-synuclein (α-syn) into neurotoxic amyloids underlies the pathogenesis neurodegenerative diseases such as Parkinson's disease (PD). 4-Phenylbutyrate (PBA), an FDA drug approved for treating urea cycle disorders, has garnered significant attention a potential chemical chaperone targeting α-syn aggregation. Using in vitro assays, we demonstrated that PBA treatment alters pattern aggregation, evidenced by reduced formation oligomeric species its...
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local network...
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local network...
Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local network...
Background: Adiponectin (AdN) is an anti-inflammatory adipokine. In cell culture studies pro-inflammatory cytokines suppress AdN biosynthesis but in clinical levels are increased patients with inflammatory conditions. We explored the effects of acute and chronic inflammation on release by human adipose tissue (AT).
Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating passage molecules from blood to brain neuropil and vice versa. In models injury, BBB dysfunction associated leakage serum albumin have been shown induce pathological plasticity, neuronal hyper-excitability, seizures. The effect activity on function whether it plays role in plasticity healthy remain unclear. Here we show that induces modulation microvascular permeability has local...