A5104636307- Cardiac Imaging and Diagnostics
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Blood groups and transfusion
- Cardiac Structural Anomalies and Repair
- Regulation of Appetite and Obesity
- ECG Monitoring and Analysis
- Bone health and treatments
- Organ and Tissue Transplantation Research
- Electron Spin Resonance Studies
- Microfluidic and Capillary Electrophoresis Applications
- Erythropoietin and Anemia Treatment
- Exercise and Physiological Responses
- Cardiac and Coronary Surgery Techniques
University of Sheffield
2022-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2024
Insigneo
2024
Eindhoven University of Technology
2022
Cleveland Clinic
2004-2015
The Ohio State University
2005
Royal College of Art
2005
Ohio State University Hospital
2005
Oxford BioMedica (United Kingdom)
1995
University of Oxford
1986-1995
BackgroundSevere aortic stenosis (AS) causes a pathophysiological cascade, which impairs myocardial blood flow. This effect is exacerbated in the presence of coronary disease (CAD). Treatment with transcatheter valve implantation (TAVI) may promote reversal these conditions.Methods We performed multi-modality assessment cardiac physiology patients AS and concurrent CAD requiring percutaneous intervention, prior to six months after undergoing TAVI. Techniques include: angiography bolus...
Blood pressure, heart rate, oxygen consumption, and blood flow to the renal hind-limb vasculatures were measured in healthy, unanesthetized baboons (Papio cynocephalus) a controlled environment. Appropriate behavioral techniques applied allow reproducible elicitation of conditional emotional response (CER). Section nerves autonomic pharmacologic interventions used determine mechanisms for cardiovascular responses accompanying CER. The resistance changes vascular beds generated by rapid,...
Myocardial ischaemia results from insufficient coronary blood flow. Computed virtual fractional flow reserve (vFFR) allows quantification of proportional loss without the need for invasive pressure-wire testing. In current study, we describe a novel, conductivity model side branch flow, referred to as 'leak'. This leak is function taper and local pressure, latter which may change radically when focal disease present. builds upon previous techniques, either ignore or rely purely on anatomical...
1. In order to study the relationship between extracellular and intracellular concentrations of orthophosphate (Pi), phosphorus nuclear magnetic resonance spectra were recorded, at rest, from flexor digitorum superficialis muscle hypophosphataemic patients with vitamin D-resistant rickets, Paget's disease bone before after they had been made hyperphosphataemic by treatment drug ethylidene-1-hydroxy-1,1-bisphosphonate. Changes in intramuscular Pi estimated ratio areas adenosine...
Journal Article Biochemical mechanisms of acute contractile failure in the hypoxic rat heart Get access PAUL M MATTHEWS, MATTHEWS * From Department Biochemistry, University Oxford, Oxford *Present address: M-105, Office Student Affairs, Stanford School Medicine, Stanford, CA 94305, USA. Search for other works by this author on: Academic PubMed Google Scholar DORIS J TAYLOR, TAYLOR GEORGE K RADDA Cardiovascular Research, Volume 20, Issue 1, January 1986, Pages 13–19,...
The practical application of 'virtual' (computed) fractional flow reserve (vFFR) based on invasive coronary angiogram (ICA) images is unknown. objective this cohort study was to investigate the potential vFFR guide management unselected patients undergoing ICA. hypothesis that it changes in >10% cases. computed using Sheffield VIRTUheart system, at five hospitals North England, 'all-comers' ICA for non-ST-elevation myocardial infarction acute syndrome (ACS) and chronic (CCS). cardiologists'...
BACKGROUND--Patients with respiratory failure have early fatiguability which may be due to limitation of oxygen supply for oxidative (mitochondrial) ATP synthesis. Skeletal muscle in exercise and recovery was studied examine the effect chronic hypoxia on mitochondrial activity vivo. METHODS--The skeletal five patients (PaO2 < 9 kPa) by phosphorus-31 magnetic resonance spectroscopy compared 10 age sex matched controls. Patients lay a 1.9 Tesla superconducting magnet gastrocnemius overlying...
We present calculations of the lowest excited electronic states TiO(2) molecule. These are computed using several correlated wavefunction response based methods, as well time-dependent density functional theory a range functionals. Surprisingly lower cost in particular second-order CC2 and CIS(D) completely fail to describe (1)B(2) (1)A(2) Density methods fare better but still show considerable variation amongst Thus provides strenuous test for state methods.
Six control dogs, six dogs treated with 1.5 mg/kg b.i.d. quinapril, and 8 q.d. minoxidil underwent 6 hours daily of hindquarter compression for 9 weeks. Minoxidil significantly decreased baseline blood pressure (-17 mm Hg; p less than or equal to 0.01), whereas quinapril 11 Hg but not (p = 0.15). Hindquarter elicited increases in all three groups (control +18, +13, +19 Hg). After weeks, left ventricular mass increased 22% 0.004); a similar increase was seen minoxidil-treated (+22%, 0.0001)...
Magnetic resonance spectroscopy (MRS) was performed on a superficial part of the brain containing large multiple sclerosis (MS) lesion. Reduced levels phosphocreatine (PCr) relative to adenosine triphosphate (ATP) were found suggesting an abnormality in energy metabolism, with increase phosphodiester (PDE) peak. A follow up study 16 months later revealed reduction size lesion MRI and normal intracellular biochemistry by MRS. Four MS patients without visible cerebral lesions showed no...
Increased coronary microvascular resistance (CMVR) is associated with dysfunction (CMD). Although CMD more common in women, sex-specific differences CMVR have not been demonstrated previously.To compare between men and women being investigated for chest pain.We used a computational fluid dynamics (CFD) model of human physiology to calculate absolute based on invasive angiographic images pressures 203 arteries from 144 individual patients. was significantly higher than (860 [650-1,205] vs....
The next revolution in biology is predicted to be the integrative domain, and need involve physiologists this kind of research has been recognized. This paper represents an approach providing some tools required for dealing with physiology at behavioral level. Video tape recordings are made activities a group five baboons (Papio hamadryas) while simultaneous arterial blood pressure, heart rate, renal flow, mesenteric or iliac flow telemetered from two members group. cardiovascular...
Heart rate, arterial blood pressure, and renal mesenteric or femoral flow were telemetered from 11 Papio hamadryas in an untethered free-ranging situation. The animals' behavior was recorded on videotape, the cardiovascular (CV) data audio channels of tape. coded, codes linked to CV via a time-code generator computer control. digitized into 1-s intervals, static relations between measures postures/locomotions (P/Ls) associated with analyzed. total frequency distributions for heart...
<h3>Introduction</h3> Murray's law relates blood flow (Q) to vessel diameter (D) (Q ∝ D3) in coronary trees. As a fundamental physiological law, it is used inform various computational techniques for deriving physiology, including virtual fractional reserve (vFFR), absolute distal (Qd) and microvascular resistance (CMVR). However, the cubed exponent of 3.0 disputed; Huo Kassab suggests that 2.33. The aim this study was assess sensitivity flow-diameter computed physiology. <h3>Methods</h3>...
Abstract Background In the Complete Revascularization with Multivessel PCI for Myocardial Infarction (COMPLETE) trial, patients ST-segment-elevation myocardial infarction (MI) who underwent staged revascularization of non-culprit coronary stenoses experienced fewer major adverse cardiovascular events than those a culprit-only approach (1). Inclusion was, however, based on angiographic and not physiological criteria. Purpose To analyse, using computational modelling, significance lesions...
Abstract To employ a reduced-order cardiovascular model as digital twin for personalised medicine, it is essential to understand how uncertainties in the model’s input parameters affect its outputs. The aim identify set of that can serve clinical biomarkers, providing insight into patient’s physiological state. Given challenge finding useful data, careful consideration must be given experimental design used acquire patient-specific parameters. In this paper, we conduct first quantification...
The baroreflex is one of the most important control mechanisms in human cardiovascular system. This work utilises a closed-loop silico model regulation, coupled to pulsatile mechanical models with (i) heart chamber and 36-parameters (ii) four chambers 51 parameters. We perform first global sensitivity analysis these systems which considers both parameters, compare their respective unregulated equivalents. Results show reduced influence regulated parameters compared equivalents that,...
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