A5100650699- Botulinum Toxin and Related Neurological Disorders
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Head and Neck Surgical Oncology
- Immune Response and Inflammation
- Temporomandibular Joint Disorders
- Drug-Induced Hepatotoxicity and Protection
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Natural Compounds in Disease Treatment
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Advanced Numerical Analysis Techniques
- NF-κB Signaling Pathways
- ATP Synthase and ATPases Research
- Bone Metabolism and Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion Transport and Channel Regulation
- Bone and Dental Protein Studies
- Autophagy in Disease and Therapy
Sun Yat-sen University
2010-2022
Stomatology Hospital
2021
Sun Yat-sen University Cancer Center
2020
Jiangsu Normal University
2019
First Affiliated Hospital of Zhengzhou University
2014
A large body of evidence has demonstrated that the ectopic discharges action potentials in primary afferents, resulted from abnormal expression voltage gated sodium channels (VGSCs) dorsal root ganglion (DRG) neurons following peripheral nerve injury are important for development neuropathic pain. However, how affects VGSCs is largely unknown. Here, we reported selective motor fibers by L5 ventral transection (L5-VRT) up-regulated Nav1.3 and Nav1.8 at both mRNA protein level increased...
Human bcl-2 gene is an apoptosis-related oncogene containing a GC-rich sequence which located upstream from P1 promoter and has the potential to form G-quadruplex structures. However, regulatory role of quadruplex effect its ligands on have not been clarified. Here, we demonstrated that structure was disrupted when partial mutation G → A made, resulting in 2-fold increase basal transcriptional activity promoter. Quindoline derivatives, highly active developed by our group, could...
Abstract: Previous studies have indicated that the nephrotoxicity induced by mesoporous silica nanoparticles (MSNs) is closely related to inflammation. Nuclear factor kappa B (NF-κB), a common rapid transcription associated with inflammation, plays an important role in process of many kidney diseases. Acute toxicity assessment high-dose exposure critical for development nanoparticle, as part standardized procedures evaluation their toxicity. The present study was undertaken observe acute...
Abstract Exosomes derived from tumor cells play a key role in development. In the present study, we identified bioactivity of exosomes released WERI-Rb1 retinoblastoma angiogenesis, as well underlying mechanism, through biochemical methods and animal experiments. Our vitro data showed that could be engulfed by human vesicle endothelial (HUVECs), significantly promote cell viability induce an inflammatory response HUVECs increasing expression series related genes, such IL-1, IL-6, IL-8,...
Ocular inflammation is a common pathological condition of series retinal degenerative diseases. Tetramethylpyrazine (TMP), Chinese herbal extraction, widely used in the treatment several ocular diseases Eastern countries. However, exact mechanisms correlating vision protective effects TMP have not been elucidated. Thus, this study aimed to investigate TMP's molecular targets anti-inflammatory activity endotoxin lipopolysaccharide (LPS)-induced both vitro and vivo. The primary cultured...
Objectives. Bones constitute organs that are engaged in constant self-remodelling. Osteoblast and osteoclast homeostasis during remodelling contribute to overall skeletal status. Orthodontics is a clinical discipline involves the investigation implementation of moving teeth through bone. The application mechanical force causes an imbalance between osteogenesis alveolar bone, leading tooth movement. Osteoimmunology comprises crosstalk immune systems regulate osteoclast–osteoblast homeostasis....
Aquaporin 9 plays critical roles in aspects of energy homeostasis, metabolism, gluconeogenesis, fat synthesis and even the individual growth development. So (AQP9) gene is a potential candidate for bovine traits. In this study, we detected polymorphism AQP9 including all exons by PCR-SSCP DNA sequencing methods with six pairs PCR primers 555 individuals from three cattle breeds. Three novel SNPs (NC_007308:g.47575 C > T, 47615 47690A G) were using P6 primer. The linkage disequilibrium...
GATA binding protein 3 (Gata3), a zinc-finger transcription factor, plays an important role in neural development. However, its expression and bioactivity the retina remain unclear. In present study, our data indicated that Gata3 maintains precursor state of 661W cells, silencing induces cell differentiation. The Nestin, marker was significantly decreased parallel, whereas Map2, differentiated neurons, increased following decrease Gata3. Neurite outgrowth by 2.78-fold Gata3-silenced cells....