Gareth D. Holmes

ORCID: 0000-0003-1120-8731
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About
Contact & Profiles
Research Areas
  • Sphingolipid Metabolism and Signaling
  • Plant Diversity and Evolution
  • Plant and animal studies
  • Immune cells in cancer
  • Genetic diversity and population structure
  • Genomics and Phylogenetic Studies
  • Phagocytosis and Immune Regulation
  • Ecology and Vegetation Dynamics Studies
  • Plant and Fungal Species Descriptions
  • Cytokine Signaling Pathways and Interactions
  • Plant Taxonomy and Phylogenetics
  • Mycorrhizal Fungi and Plant Interactions
  • Plant Pathogens and Fungal Diseases
  • Erythrocyte Function and Pathophysiology
  • Botany, Ecology, and Taxonomy Studies
  • Marine and coastal plant biology
  • Acute Myeloid Leukemia Research
  • Psoriasis: Treatment and Pathogenesis
  • Botanical Research and Applications
  • Botanical Studies and Applications
  • Species Distribution and Climate Change
  • Cephalopods and Marine Biology
  • Fern and Epiphyte Biology
  • Cocoa and Sweet Potato Agronomy
  • Coastal wetland ecosystem dynamics

Royal Botanic Garden Sydney
2014-2024

Royal Botanic Gardens Victoria
2014-2024

La Trobe University
2018-2022

The University of Melbourne
2008-2022

Princess Margaret Cancer Centre
2018-2020

University Health Network
2018-2020

Royal Botanic Gardens, Kew
2016

Manaaki Whenua – Landcare Research
2012

Abstract Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from stem cells (LSC) that share some hematopoietic cell (HSC) programs including responsiveness to inflammatory signaling. Although inflammation dysregulates mature and influences stemness lineage determination in HSCs by activating stress myelopoiesis, such roles LSCs are poorly understood. Here, we show S1PR3, receptor for the bioactive lipid sphingosine-1-phosphate, central regulator drives...

10.1158/2643-3230.bcd-20-0155 article EN Blood Cancer Discovery 2020-12-01

Background Rutaceae subfamily Rutoideae (46 genera, c. 660 species) is diverse in both rainforests and sclerophyll vegetation of Australasia. Australia New Caledonia are centres endemism with a number genera species distributed disjunctly between the two regions. Our aim was to generate high-level molecular phylogeny for Australasian identify major clades as framework assessing morphological biogeographic patterns taxonomy. Methodology/Principal Findings Phylogenetic analyses were based on...

10.1371/journal.pone.0072493 article EN cc-by PLoS ONE 2013-08-13

Acacia (Leguminosae, Caesalpinioideae, mimosoid clade) is the largest and most widespread genus of plants in Australian flora, occupying dominating a diverse range environments, with an equally forms. For its size importance, currently has surprisingly few genomic resources. pycnantha, golden wattle, woody shrub or tree occurring south-eastern Australia country's floral emblem. To assemble genome for A. we generated long-read sequences using Oxford Nanopore Technology, 10x Genomics Chromium...

10.1371/journal.pone.0274267 article EN cc-by PLoS ONE 2022-10-14

Mycorrhizal fungi are a critical component of the ecological niche most plants and can potentially constrain their geographical range. Unlike other types mycorrhizal fungi, distributions orchid (OMF) at large spatial scales not well understood. Here, we investigate distribution diversity Ceratobasidium OMF in orchids soils across Australian continent.We sampled 217 isolates from 111 species southern Australia combined these with 311 sequences GenBank. To estimate taxonomic associating...

10.1093/aob/mcab067 article EN Annals of Botany 2021-05-29

When conserving rare plant species, managers are often faced with small and/or isolated populations displaying low levels of sexual reproduction and genetic variation. One option for reinvigorating these is the introduction material from other sites, but in some cases fitness may be reduced as a result outbreeding depression. Here pollination biology shrub Grevillea repens studied across its natural range reproductive responses following cross-pollination among examined to determine factors...

10.1093/aob/mcn195 article EN Annals of Botany 2008-10-15

In Australia, Poaceae tribe Poeae are represented by 19 genera and 99 species, including economically environmentally important native introduced pasture grasses [e.g. Poa (Tussock-grasses) Lolium (Ryegrasses)]. We used this tribe, which well characterised in regards to morphological diversity evolutionary relationships, test the efficacy of DNA barcoding methods. A reference library was generated that included 93.9% species Australia (408 individuals, [Formula: see text] = 3.7 individuals...

10.1371/journal.pone.0186259 article EN cc-by PLoS ONE 2017-10-30

Common Reed (Phragmites australis) is a frequent component of inland and coastal wetlands in temperate zones worldwide. Ongoing environmental changes have resulted the decline this species many areas invasive expansion others. In Gippsland Lakes waterway system south-eastern Australia, increasing salinity thought to contributed loss fringing P. australis reed beds leading increased shoreline erosion. A major goal restoration address effect by planting genetically diverse range salt-tolerant...

10.3389/fpls.2016.00432 article EN cc-by Frontiers in Plant Science 2016-04-13

In orchid conservation, quantifying the specificity of mycorrhizal associations, and establishing which species use same fungal taxa, is important for sourcing suitable fungi symbiotic propagation selecting sites conservation translocation. For Caladenia subgenus Calonema (Orchidaceae), contains 58 threatened species, we ask following questions. (1) How many taxa Serendipita do associate with? (2) Do share with common Caladenia? (3) geographically widespread are associated

10.1093/aob/mcaa116 article EN Annals of Botany 2020-06-18

The generation and analysis of genome-scale data—genomics—is driving a rapid increase in plant biodiversity knowledge. However, the speed complexity technological advance genomics presents challenges for its widescale use evolutionary conservation biology. Here, we introduce describe national-scale collaboration conceived to build genomic resources capability understanding Australian flora: Genomics Plants (GAP) Framework Initiative. We outline (a) history project including collaborative...

10.32942/x2rp70 preprint EN 2024-07-08

As currently circumscribed, Boronia (Rutaceae) is a large Australian genus of 148 species distributed in all states and mainland territories, Boronella confined to New Caledonia contains ~four species. We present molecular phylogenetic analyses these genera, based on chloroplast (trnL–trnF) nuclear (ITS, ETS) DNA sequences, assess their relationships infrageneric classification. Analyses strongly support the monophyly Boronia+Boronella clade that nested within Boronia. They also sections...

10.1071/sb15008 article EN Australian Systematic Botany 2015-01-01

The holly grevilleas are an informal grouping of 15 species (19 taxa) woody shrubs from south-eastern Australia, with a centre distribution in central to western Victoria. Many the narrowly endemic. present study is first molecular-phylogenetic analysis group, aim providing evolutionary framework for assessing species-level taxonomy and conservation priorities. Analyses using nrDNA internal transcribed spacer (ITS) regions were complicated by presence divergent paralogues, including inferred...

10.1071/sb13045 article EN Australian Systematic Botany 2014-01-01

Proteaceae subfamily Persoonioideae, as presently circumscribed, consists of the monogeneric tribe Placospermeae (Placospermum) and Persoonieae. The latter comprises diverse genus Persoonia monospecific genera found in New Zealand (Toronia), Caledonia (Garnieria) south-western Western Australia (Acidonia). has 101 species distributed across been classified into 11 informal groups. Using data derived from plastid DNA (trnL–trnF region), nuclear rDNA (ITS) morphological characters, we...

10.1071/sb16052 article EN Australian Systematic Botany 2018-01-01

The rainforest genus Gossia N.Snow & Guymer (Myrtaceae) occurs in Australia, Melanesia and Malesia, is capable of hyperaccumulating the heavy metal manganese (Mn). Here, we used nuclear ribosomal plastid spacer DNA-sequence data to reconstruct phylogeny 19 Australian species eight New Caledonian taxa. Our results indicated that relationship between Austromyrtus (Nied.) Burret not fully resolved, most were supported as monophyletic. Non-monophyly might be related incomplete lineage...

10.1071/sb18018 article EN Australian Systematic Botany 2018-01-01

Although the Australasian grass genus Austrostipa is species rich, abundant and ecologically significant, subgeneric classification of its 62 has not been comprehensively tested with molecular data. We used three markers from 51 to determine a phylogeny found strong support for following seven existing subgenera: Falcatae, Austrostipa, Aulax, Lobatae, Bambusina, Lancea Longiaristatae. The data do Tuberculatae Eremophilae, which could be combined subgenus Austrostipa. are equivocal or...

10.1071/sb10049 article EN Australian Systematic Botany 2012-01-01

Philotheca sect. Erionema includes 14 species from eastern Australia and one south-western Australia. We conducted a phylogenetic analysis of the section, including samples all species, using sequences ITS ETS regions nuclear ribosomal DNA. Results were broadly congruent with previous based on morphological flavonoid data. The is consistent monophyly section supports six represented by multiple samples. verrucosa (A. Rich.) Paul G. Wilson was resolved as paraphyletic respect to P. freyciana...

10.1071/sb22003 article EN cc-by-nc-nd Australian Systematic Botany 2022-09-16

Abstract Narrowly endemic species are particularly vulnerable to catastrophic events. Compared widespread species, they may also be less capable of adapting shifts in environmental pressures as a result specialisation on narrow range local condition and limited ability disperse. However, life-history traits, such preferential outcrossing high fecundity can maintain genetic diversity evolutionary potential, boost resilience. The endangered Grevillea bedggoodiana (Enfield Grevillea) is an...

10.1007/s10592-022-01480-4 article EN cc-by Conservation Genetics 2022-11-05

Stipitate Thelephorales are basidiomycetous, mostly hydnoid, ectomycorrhizal fungi. Some species have declined considerably, and some threat-listed as vulnerable or endangered. These ecological concerns require a well-resolved taxonomy to understand diversity in this group of fungi facilitate conservation. However, phylogenetic studies neglected Southern Hemisphere representatives. This study examines the fleshy stipitate from native forests Australia New Zealand, using morphological...

10.1080/00275514.2024.2363211 article EN Mycologia 2024-08-29

Premise Motivated to make sensible interpretations of the massive volume data from Australian Microbiome Initiative (AusMic), we characterize soil mycota Australia. We establish operational taxonomic units (OTUs) and compare these GenBank a set National Herbarium Victoria (MEL), Melbourne, also provide visualizations Agaricomycete diversity, drawn our analyses AusMic sequences taxonomy. Methods The internal transcribed spacer (ITS) were filtered create OTUs, which searched against Center for...

10.1002/aps3.11392 article EN cc-by-nc Applications in Plant Sciences 2020-09-01

Sclerolaena napiformis is an endangered chenopod with a disjunct distribution. Here, we report the complete genomes of two geographically isolated accessions. The genomes, respectively, were 151,112 and 151,291 bp in length pair inverted repeats (IRs) 24,345 24,339 separated by large single-copy region (LSC) 83,893 84,113 small (SSC) 18,529 18,500 bp, CG content 36.57% 36.53%. In total, 130 genes annotated, including 85 protein-coding genes. Phylogenetic analysis up to 87 from 22 plastomes...

10.1080/23802359.2020.1734498 article EN cc-by-nc Mitochondrial DNA Part B 2020-03-04

<div>Abstract<p>Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from stem cells (LSC) that share some hematopoietic cell (HSC) programs including responsiveness to inflammatory signaling. Although inflammation dysregulates mature and influences stemness lineage determination in HSCs by activating stress myelopoiesis, such roles LSCs are poorly understood. Here, we show S1PR3, receptor for the bioactive lipid sphingosine-1-phosphate, central regulator...

10.1158/2643-3230.c.6549814.v1 preprint EN 2023-04-04
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