A5018006614- Genetic diversity and population structure
- Physiological and biochemical adaptations
- Avian ecology and behavior
- Bat Biology and Ecology Studies
- High Altitude and Hypoxia
- Species Distribution and Climate Change
- Genetic and phenotypic traits in livestock
- Lung Cancer Diagnosis and Treatment
- Fish Ecology and Management Studies
- Arctic and Russian Policy Studies
- Animal Ecology and Behavior Studies
- Food Industry and Aquatic Biology
- COVID-19 and healthcare impacts
- Ecology and Vegetation Dynamics Studies
- Coastal and Marine Management
- Cardiovascular Function and Risk Factors
- Bird parasitology and diseases
- Spider Taxonomy and Behavior Studies
- Plant and animal studies
- Esophageal Cancer Research and Treatment
- Animal Vocal Communication and Behavior
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Coronary Interventions and Diagnostics
- Wildlife Ecology and Conservation
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Institute of Zoology
2015-2024
Chinese Academy of Sciences
2010-2024
Mianyang Third People's Hospital
2020-2024
Tongde Hospital of Zhejiang Province
2024
Hebei University
2023-2024
University of Chinese Academy of Sciences
2017-2023
Weatherford College
2023
Sichuan Agricultural University
2022
Zhengzhou Normal University
2022
In the absence of nuclear-genomic differentiation between two populations, deep mitochondrial divergence (DMD) is a form mito-nuclear discordance. Such instances DMD are rare and might variably be explained by unusual cases female-linked selection, male-biased dispersal, "speciation reversal" or capture through genetic introgression. Here, we analyze in an Asian Phylloscopus leaf warbler (Aves: Phylloscopidae) complex. Bioacoustic, morphological, genomic data demonstrate close similarity...
When different species experience similar selection pressures, the probability of evolving adaptive solutions may be influenced by legacies evolutionary history, such as lineage-specific changes in genetic background. Here we test for convergence hemoglobin (Hb) function among high-altitude passerine birds that are native to Qinghai-Tibet Plateau, and examine whether convergent increases Hb–O 2 affinity have a molecular basis species. We documented parid aegithalid from Plateau evolved...
Abstract Phylogenetic trees based on genome-wide sequence data may not always represent the true evolutionary history for a variety of reasons. One process that can lead to incorrect reconstruction species phylogenies is gene flow, especially if interspecific flow has affected large parts genome. We investigated phylogenetic relationships within clade comprising eight passerine birds (Phylloscopidae, Phylloscopus, leaf warblers) using one de novo genome assembly and 78 resequenced genomes....
Glutathione S-transferases (GSTs) exist in various eukaryotes and function detoxification of xenobiotics response to abiotic biotic stresses. We have carried out a genome-wide survey this gene family 10 plant genomes. Our data show that tandem duplication has been regarded as the major expansion mechanism both monocot dicot plants may practiced different evolutionary history. Non-synonymous substitutions per site (Ka) synonymous (Ks) analyses showed N- C-terminal functional domains GSTs...
High-altitude environments present strong stresses for living organisms, which have driven striking phenotypic and genetic adaptations. While previous studies revealed multiple adaptations in high-altitude species, how evolutionary history (i.e., phylogenetic background) contributes to similarity is largely unknown, particular a group of birds. We explored this 3 passerine birds from the Qinghai-Tibet Plateau their low-altitude relatives lowland eastern China. generated transcriptomic data 5...
Known as the 'third polar region', Qinghai-Tibet Plateau represents one of harshest highland environments in world and yet a number organisms thrive there. Previous studies birds, animals humans have focused on well-differentiated populations later stages phenotypic divergence. The adaptive processes during initial phase adaptation remain poorly understood. We studied human commensal, Eurasian Tree Sparrow, which has followed agriculture to Plateau. Despite strong differentiation at multiple...
Abstract Species that undertake altitudinal migrations are exposed to a considerable seasonal variation in oxygen levels and temperature. How they cope with this was studied population of great tit ( Parus major ) breeds at high elevations winters lower the eastern Himalayas. Comparison genomics tits those living lowlands revealed an accelerated genetic selection for carbohydrate energy metabolism (amino sugar, nucleotide sugar insulin signaling pathways) hypoxia response (PI3K-akt, mTOR...
Background: This study aimed to evaluate the effect of Shenbing Decoction III (SBD III) and its key Apigenin on peritoneal dialysis (PD)–induced fibrosis explore underlying mechanisms. Methods: Liquid chromatography–mass spectrometry confirmed presence in SBD III. Human mesothelial cells (HMrSV5) were stimulated with PD solution (PDS) induce fibrosis, treatment was administered. Results: PDS decreased cell viability increased migration invasion capabilities HMrSV5 cells. It also reduced...
Significance A reduction in heterozygosity may limit the opportunity for species facing same selective pressures to evolve parallel adaptation. Examining 19 East Asian tits’ genomes, we find a pattern of lower western endemics compared with that found both eastern and widespread taxa, consistent expectations demographic contraction driven by late-Pleistocene climate fluctuations. Comparisons among endemic tits disproportionate levels genetic differentiation between pairs lowland highland...
The blood urea nitrogen to creatinine ratio (BCR) and estimated plasma volume status (ePVS) may be prognostic markers in heart failure (HF), but their combined efficacy is unclear. This research aims determine the utility of BCR ePVS critically ill HF patients intensive care unit. Data from MIMIC-IV database were analyzed. was calculated using hemoglobin hematocrit levels with Strauss-derived Duarte method. primary outcome 1-year all-cause mortality (ACM). Receiver operating characteristic...
Abstract Aim The Pleistocene glacial cycles play a prominent role in shaping phylogeographical patterns of organisms, while few studies have focused on the regional difference effects. By acquiring comprehensive knowledge origin, diversification and historical demography an intensively studied passerine species complex, Great Tit, we aim to test variation Late glaciation impacts this widely distributed bird lineage. Location Eurasia associated peninsulas archipelagos. Taxa Parus major...
Beak morphology exhibits considerable adaptive plasticity in birds, which results highly varied or specialized forms response to variations ecology and life history. As the only parid species endemic Qinghai-Tibet Plateau, Ground Tit (Parus humilis) has evolved a distinctly long curved beak from other parids. An integration of morphometrics, phylogenetics, transcriptomics embryology allows us address evolutionary developmental mechanisms structure observed Tit.A morphometric approach...
Skeletal muscle plays a central role in regulating glucose uptake and body metabolism; however, highland hypoxia is severe challenge to aerobic metabolism small endotherms. Therefore, understanding the physiological genetic convergence of tolerance has potential broad range medical implications. Here we report experimentally validate common mechanism across multiple high-altitude songbirds that improvement insulin sensitivity contributes homeostasis, low oxygen consumption, relative...
Abstract Song is considered to play an important role in the maintenance of prezygotic reproductive isolation between closely related songbird species. Therefore, song mixing a contact zone species often as evidence hybridization. The Sichuan Leaf Warbler Phylloscopus forresti and Gansu kansuensis, which diverged 2 million years ago, have formed south Province China, where mixed songs been observed. In this study, we investigated potential causes consequences by integrating bioacoustic,...
Background/Aims: Genomic adaptations to high altitudes have been well studied in the last several years; however, roles of microRNAs (miRNAs), which are essential modulators a variety genes and key cellular processes, rarely explored. Here, we explored interactions between miRNAs their target as an adaptation altitude avian species, great tit (Parus major), is widely distributed across Eurasian continent at 4500 m sea level. Because MAPK signaling pathway plays crucial role hypoxia response...
Pectoralis phenotypic variation plays a fundamental role in locomotion and thermogenesis highland birds. However, its regulatory metabolic mechanisms remain enigmatic to date. Here, we integrated phenomic, transcriptomic, metabolomic approaches determine muscle underpinning across altitudinal songbirds. Phenomics confirmed that all birds had considerable increases oxidative capacity, capillarity, mitochondrial abundance our study. Correspondingly, transcriptomic analyses found differentially...
Abstract Rare and geographically restricted species may be vulnerable to genetic effects from inbreeding depression in small populations or swamping through hybridization with common species, but a third possibility is that selective gene flow can restore fitness (genetic rescue). Climate-sensitive pikas (Ochotona spp.) of the Qinghai–Tibetan Plateau (QHTP) its vicinity have been reduced residual movement climatic zones during Pleistocene recent anthropogenic disturbance, whereas plateau...
Patterns of heterogeneous genomic differentiation have been well documented between closely related species, with some highly differentiated regions ("genomic islands") spread throughout the genome. Differential levels gene flow are proposed to account for this pattern, as islands suggested be resistant flow. Recent studies also that could explained by linked selection acting on low recombination rates. Here, we investigate and gene-flow patterns autosomes using RAD-seq data two species...
To determine the prognostic value of cumulative calcification score coronary artery (CAC), thoracic aortic (TAC) and valve (AVC) in acute ST segment elevation myocardial infarction (STEMI) patients.
The rate of mutation accumulation in germline cells can be affected by cell replication and/or DNA damage, which are further related to life history traits such as generation time and body mass. Leveraging the existing datasets 233 neoavian bird species, here, we investigated whether mass contribute interspecific variation orthologous microsatellite length, transposable element (TE) deletion length how these genomic attributes affect genome sizes. In nonpasserines, found that is correlated...
Abstract Different genomic regions may reflect conflicting phylogenetic topologies primarily due to incomplete lineage sorting and/or gene flow. Genomic data are necessary reconstruct the true species tree and explore potential causes of conflict. Here, we investigate relationships 4 Emberiza (Aves: Emberizidae) discuss observed mitochondrial non-monophyly godlewskii (Godlewski’s bunting) using phylogenomic analyses based on whole genome resequencing from 41 birds. Analyses both ~39...
The phenotypic plasticity in responses to short-term stress can provide clues for understanding the adaptive fixation mechanism of genetic variation during long-term exposure extreme environments. However, few studies have compared with evolutionary patterns; particular, no interactions between two processes been evaluated high-altitude environment. We performed RNA sequencing embryo fibroblasts derived from great tits and mice explore transcriptional after simulated environmental stresses....