A5087249179- Atherosclerosis and Cardiovascular Diseases
- Pneumonia and Respiratory Infections
- Immune cells in cancer
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Pericarditis and Cardiac Tamponade
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Potassium and Related Disorders
- Protease and Inhibitor Mechanisms
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Alzheimer's disease research and treatments
- Macrophage Migration Inhibitory Factor
- Viral Infections and Immunology Research
- Fatty Acid Research and Health
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Respiratory viral infections research
- Metabolomics and Mass Spectrometry Studies
- Systemic Lupus Erythematosus Research
- Lipid Membrane Structure and Behavior
- Nuclear Receptors and Signaling
- Advanced Proteomics Techniques and Applications
- Chronic Disease Management Strategies
The University of Western Australia
2019-2025
Harry Perkins Institute of Medical Research
2019-2025
Fiona Stanley Hospital
2023
Curtin University
2021
Pneumonia triggers an inflammatory response that can persist beyond resolution of infection. This may increase the risk major adverse cardiac events (MACE) in people with known coronary artery disease (CAD). To assess impact pneumonia on MACE individuals pre-existing CAD. We identified patients who had revascularisation procedures 7 hospitals Western Australia between 2000-2005. Multivariable Cox regression models assessed association time-dependent and [composite all-cause death +...
Acute pneumonia is characterised by a period of intense inflammation. Inflammation now considered to be key step in atherosclerosis progression. In addition, pre‑existing atherosclerotic inflammation play role progression and risk. the present study, multiple comorbidities murine model was used study respiratory systemic that results from setting atherosclerosis. Firstly, minimal infectious dose <em>Streptococcus pneumoniae</em> (TIGR4 strain) produce clinical with low mortality rate (20%)...
Abstract Residual inflammation in cardiovascular organs is thought to be one of the catalysts for increased risk complications seen following pneumonia. To test this hypothesis, we investigated changes plaque characteristics and inflammatory features ApoE −/− mouse aorta heart Male mice were fed a high fat diet 8 weeks before intranasal inoculation with either Streptococcus pneumoniae serotype 4 (test group) or phosphate buffered saline (control group). Mice sacrificed at 2-, 7- 28-days...
Background: The PRESENILIN genes (PSEN1, PSEN2) encoding for their respective proteins have critical roles in many aspects of Alzheimer’s disease (AD) pathogenesis. PS2V transcript PSEN2 encodes a truncated protein and is upregulated AD brains; however, its relevance to progression remains be determined. Objective: Assess levels postmortem non-AD brain tissue lymphocytes collected under the Australian Imaging Biomarker Lifestyle (AIBL) study. Methods: Full length were assessed by...
ABSTRACT Background Inflammation is a risk factor for atherosclerosis progression. Hospitalisation pneumonia associated with increased of cardiovascular disease. Herein, we describe multiple comorbidities murine model to study the impact bacterial on atherosclerosis. Methods Firstly, minimal infectious dose Streptococcus pneumoniae (TIGR4 strain) produce clinical low mortality rate (20%) was established. C57Bl/6 ApoE-/- mice were fed high-fat diet prior administering intranasally 10 5 colony...
Background: Pneumonia triggers an inflammatory response that can persist beyond resolution of infection. This may increase the risk major adverse cardiac events (MACE) in people with no known coronary artery disease (CAD). However, impact pneumonia on MACE individuals existing CAD remains unknown. Methods: We identified patients who had revascularisation procedures 7 hospitals Western Australia between 2000-2005. Multivariable Cox regression models assessed association time-dependent and...