Acrylamide (ACR) formed during heating of tobacco and carbohydrate-rich food as well widely applied in industries has been known a well-established neurotoxic pollutant. Although the precise mechanism is unclear, enhanced apoptosis, oxidative stress inflammation have demonstrated to contribute ACR-induced neurotoxicity. In this study, we assessed possible anti-apoptotic, antioxidant anti-inflammatory effects curcumin, most active component popular spice turmeric, on neurotoxicity caused by...

The anti-cancer activities of brown algae and some active extracts or components from have been demonstrated.

Bioactivities of fucoidan, a class marine algal polysaccharides, vary depending on the original species. The aim this study was to explore in vivo immunomodulatory activity fucoidan from Undaria pinnatifida, brown alga with long history medicinal and food uses East Asia, sarcoma 180 (S180) subcutaneous xenograft-bearing mice. Results showed that oral administration significantly enhanced phagocytotic function mononuclear phagocytic system, increased serum levels Th1 cytokines interleukin-2,...

Due to the expensive cost and uncertain effectiveness of environmental management options in eliminating pharmaceutical residues, recently, decreasing emission pollutants from a drug administration perspective has been considered hot area research. As kind for environment, ecopharmacovigilance (EPV) emphasizes source control pollutants. Disposal unwanted medicines as easiest target contamination. Here, we focused on public attitudes practice regarding disposal EPV among 365 Chinese...

Abstract Background During interprofessional clinical practice, compared to understanding of one’s own professional role and function, it might be more difficult clarify the roles contributions other health-care team members because inter-professional barrier. In order provide students opportunity for real experience with professions in environments enhance their perceptions professions’ roles, this study developed a comprehensive multi-dimension extracurricular education (IPE) model through...

Shortage of health professionals is one the most important barriers for community centers to provide quality primary care chronic disease patients especially after outbreak COVID-19. Under such condition, medical students have been well-accepted as a force multiplier community-based service. Community service learning (CSL) based on student-led education support self-management might be valuable interactive tool in education. This study compared attitudes toward among three stakeholder roles...

The mechanisms associated with edema formation after traumatic brain injury (TBI) have not been fully elucidated. In peripheral tissue injury, the neurogenic component of inflammation plays a significant role in increased vascular permeability and formation. However, few studies examined neuropeptide induced following TBI. Adult male Sprague-Dawley rats were either left untreated, or pre-treated capsaicin (125 mg/kg s.c.) equal volume vehicle, injured 14 days later using 2-meter...

The use of functional foods and their bioactive components is receiving increasing attention as a complementary alternative therapy for chronic ulcerative colitis (UC). This study explored the protective effect mechanisms Eckol, seaweed-derived phlorotannin, on dextran sodium sulfate (DSS)-induced UC in mice. Eckol (0.5–1.0 mg/kg) reduced DSS-enhanced disease activity indexes, alleviated shortening colon length colonic tissue damage contents tumor necrosis factor (TNF)-α, interleukin...

The anti-inflammatory activity of eckol, a phlorotannin constituent marine brown algae, has been widely demonstrated. Here, we found eckol at doses 0.5–1.0 mg/kg protected against development dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. DSS-elevated colonic tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 levels as well nuclear kappa B(NF-κB)p65 and Toll like receptor (TLR)-4 expression were significantly suppressed, the IL-10 level was enhanced...

This study aimed to evaluate in vitro the possible mechanisms underlying estrogenic potential of benzalkonium chloride (BAC) as a disinfectant emerging contaminant. Effects BAC at environmentally-relevant concentrations on estrogen synthesis and receptor (ER) signaling were assessed using H295R steroidogenesis assay MCF-7 proliferation assay, respectively. Results showed that exposure 1.0-1.5 mg/L for 48 h significantly increased estradiol production cells concentration-dependent manner....

As a pancreatic inflammatory marker, regenerating isletderived protein 3A (Reg3A) plays key role in inflammationassociated carcinogenesis by promoting cell proliferation, inhibiting apoptosis, and regulating cancer migration invasion.This study aimed to reveal novel immuno-regulatory mechanism which Reg3A modulates tumour-promoting responses during (PC) progression.In an vitro Transwell system that allowed the direct co-culture of human peripheral blood-derived dendritic cells (DCs)...

Chitooligosaccharides(COS) as potential functional food has been paid great attention because of their outstanding biological activities. Here, we found COS (250 and 500 mg/kg) protected against development dextran sodium sulfate(DSS)- induced chronic experimental ulcerative colitis(UC) in mice. DSS-elevated serum colonic tumor necrosis factor(TNF)-α, interleukin(IL)-1β IL-6 levels were significantly supressed. TUNEL+ apoptoic cells Cleaved Caspase-9 expression downregulated, Ki-67+...

Abstract Background: As a chemical extensively used in industrial areas as well formed during heating of carbohydrate-rich food and tobacco, acrylamide (ACR) has been known well-established neurotoxic pollutant. Although the precise mechanism is unclear, enhanced apoptosis, oxidative stress inflammation have demonstrated to contribute ACR-induced neurotoxicity. In this study, we assessed possible anti-apoptotic, antioxidant anti-inflammatory effects curcumin, most active component popular...

Abstract: At present, fostering and promoting empathy, an important humanistic quality, are believed ethical imperatives, should be carried through the pharmacy education to facilitate interpersonal philosophical development of healthcare students. A cross-sectional study used JSE-HPS (Jefferson Scale Empathy-Health Profession Student version) assess 263 Chinese undergraduates from 1st 4th year at Wuhan University Science Technology. Attached scale was a survey containing questions on...

Background A sharp rise in household consumption of disinfectants triggered by COVID-19 pandemic has generated tremendous environmental burden and risks disinfectant emissions the post-pandemic period. To address this emerging challenge, replacing highly hazardous with more friendly alternatives been accepted as an inherently effective solution to environment issues posed contaminants. However, no study yet done explore potential customers' attitudes market prospect until now. Methods This...

Professional identity is crucial for the development of pharmacy students' professional confidence, learning motivation and future career choices. However, how to develop in education an underdeveloped field research. The critical component has been considered formed as a result stepwise socialization. Therefore, might be influenced by associations with other health care professionals, such physicians nurses, who are involved collaboration pharmacists.This work aimed investigate effect...

Abstract: Background: The importance of pharmacy practitioners’ personality traits in their professional development and future patient-centered pharmaceutical care practice has been widely recognized. Metacognitive skills critical thinking, self-directed learning as a part training emphasized the new education accreditation standard. Correlation between metacognition demonstrated patients with pathology. Objectives: This work aimed to study association among Chinese students. Materials...