A5070501006- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Cardiovascular Health and Risk Factors
- Glaucoma and retinal disorders
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic and Hepatic Oncology Research
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Sinusitis and nasal conditions
- Neuroendocrine Tumor Research Advances
- Chronic Disease Management Strategies
- Nasolacrimal Duct Obstruction Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
University of Hong Kong
2023-2024
Chinese University of Hong Kong
2024
Shantou University
2024
Third Affiliated Hospital of Southern Medical University
2019-2022
As a specific microvascular complication of diabetes, diabetic retinopathy (DR) causes severe visual impairment in patients with diabetes. The expression microRNA‑126 (miRNA/miR‑126) has previously been found to be significantly decreased the serum DR. In present study, functions miR‑126 and its mechanisms action experimental were examined rats streptozotocin (STZ)‑induced diabetes high glucose (HG)‑induced human retinal capillary endothelial cells (HRCECs). vivo, rat models established...
Cardiovascular disease (CVD) is a leading cause of mortality, especially in developing countries. This study aimed to develop and validate CVD risk prediction model, Personalized CARdiovascular DIsease Assessment for Chinese (P-CARDIAC), recurrent cardiovascular events using machine learning technique.
To investigate the expression and significance of mechanistic target rapamycin complex 1(mTORC1) in diabetic retinopathy (DR), to find new targets methods for treatment DR.A DR rat model was prepared by general feeding combined with intraperitoneal injection 10% streptozotocin (60 mg/kg). The rats were randomly divided into a control group (NDM group) diabetes (DM group). Three months later, degrees determined using hematoxylin eosin staining, levels p-S6, VEGF, PEDF proteins detected...
We present a rare case of ruptured pancreatic carcinosarcoma in 56-year-old male who underwent radical surgery and adjuvant chemotherapy. Despite the typical poor prognosis associated with this aggressive tumor, patient achieved an overall survival 20 months postoperatively. This emphasizes challenges diagnosing managing highlights potential benefits surgical chemotherapeutic interventions achieving extended survival.
Existing cardiovascular disease (CVD) risk prediction tools may not be applicable to the Chinese populations because of their development based on mostly Western cohorts and limited list covariates.To develop validate a machine learning-based model that can used by primary care physicians in Hong Kong, Personalized CARdiovascular DIsease Assessment for (P-CARDIAC), predict 10-year CVD among population.A novel algorithm Kong West Cluster cohort was designed Cox proportional hazards (CPH) with...
Abstract This study aimed to develop and validate a cardiovascular diseases (CVD) risk prediction model, Personalized CARdiovascular DIsease Assessment for Chinese (P-CARDIAC), recurrent events using Machine-Learning technique. Three cohorts of patients with established CVD in Hong Kong were included; Island cohort as the derivation cohort, whilst Kowloon New Territories validation cohorts. The 10-year outcome was composite diagnostic or procedure codes coronary heart disease, ischaemic...
Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in China worldwide while we are lacking validated prevention model specifically for Chinese. To identify people at CVD high risk offer early intervention, developed a prediction model, Personalized CARdiovascular DIsease Assessment Chinese (1°P-CARDIAC), contemporary cohorts Hong Kong. Methods: Patients without any history different geographical location residence Kong was categorized as derivation...
Abstract Background: To investigate the expression and significance of mechanistic target rapamycin complex 1(mTORC1) in diabetic retinopathy(DR), to find new targets methods for treatment DR.Methods: A DR rat model was prepared by general feeding combined with intraperitoneal injection 10% streptozotocin (60 mg/kg). The rats were randomly divided into a control group (NDM group) diabetes (DM group).Three months later,the degrees retinopathy determined using hematoxylin eosin staining,and...
Abstract Background: To investigate the expression and significance of mechanistic target rapamycin complex 1(mTORC1) in diabetic retinopathy(DR), to find new targets methods for treatment DR. Methods: A DR rat model was prepared by general feeding combined with intraperitoneal injection 10% streptozotocin (60 mg/kg). The rats were randomly divided into a control group (NDM group) diabetes (DM group). Three months later, degrees retinopathy determined using hematoxylin eosin staining, levels...