A5067481313- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Hormonal Regulation and Hypertension
- Medication Adherence and Compliance
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Electrolyte and hormonal disorders
- Cardiac pacing and defibrillation studies
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Infective Endocarditis Diagnosis and Management
- Nutrition and Health in Aging
- Pharmacological Effects and Toxicity Studies
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Peptidase Inhibition and Analysis
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Cardiovascular Health and Risk Factors
- Cardiac Arrhythmias and Treatments
University of Illinois Chicago
2014-2024
University of Illinois Urbana-Champaign
2008-2011
University of Chicago Medical Center
2006-2008
NorthShore University HealthSystem
2003-2004
Background: National guidelines recommend angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) and β-blockers (BBs) at target doses for morbidity mortality benefits in heart failure with reduced ejection fraction (HFrEF); regardless, titration of these therapies practice remains suboptimal. We implemented an outpatient pharmacist-managed HFrEF medication assistance clinic (MTAC) one institution to improve general cardiology (GC) patients. Objective: To...
Background: Patient adherence to medication regimens is critical in most chronic disease treatment plans. This study uses a patient-centered tablet app, "My Interventional Drug-Eluting Stent Educational App (MyIDEA)." an educational program designed improve patient adherence. Objective: Our goal describe the design, methodology, limitations, and results of MyIDEA app. We created mobile technology-based education app dual antiplatelet therapy patients who underwent percutaneous coronary...
To identify patient-specific factors associated with spironolactone-induced potassium level elevation in patients heart failure.Prospective cohort study.Two adult failure clinics.Sixty-two (mean +/- SD age 54 16 yrs) aldosterone antagonist-naïve failure.Patients received spironolactone 12.5 mg/day, titrated to 25 mg/day if tolerated.Blood samples were obtained at baseline, 1 week after initiation, and dose titration for assessment of baseline level, serum chemistry, angiotensinogen (AGT)...
The objective of this study was to examine the extent which aldosterone synthase genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) serum in African Americans heart failure. Clinical data, echocardiographic measurements, a sample for determination CYP11B2 -344T>C (rs1799998) were collected from 194 self-reported chronic, ambulatory Genetic determined using 105 autosomal informative markers. In sub-set patients (n = 126), also circulating aldosterone. −344C allele...
Background/Aims: This study's objective was to evaluate a patient-centered educational electronic tablet application, "My Interventional Drug-Eluting Stent Educational App" (MyIDEA) see if there an increase in patient knowledge about dual antiplatelet therapy (DAPT) and medication possession ratio (MPR) compared treatment as usual. Methods: In pilot project, 24 elderly (≥50 years-old) research participants were recruited after Drug Eluting Stent. 11 randomized the control arm 13...
The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors alirocumab and evolocumab were approved by the FDA in 2015. In anticipation of provider interest a potential increase referrals to on-site specialty pharmacy, we created pharmacist-managed consultation service.The development clinic-based service for management PCSK9 inhibitor agents is described. Key implementation steps included (a) creation pharmacy team collaboration with cardiology; (b) completion needs assessment; (c)...
To compare the frequency of achieving a therapeutic serum digoxin concentration (SDC), defined as 0.5-0.9 ng/ml, by using simplified nomogram to individualize dosing with standard practices in patients heart failure, and characterize relationship between genetic polymorphisms ABCB1 gene SDC.Prospective study historical control group.Outpatient care center an urban academic medical center.A total 131 adults failure due left ventricular dysfunction who were treated digoxin.Digoxin doses...
Study Objective. To determine whether the effects of spironolactone on potassium homeostasis vary by race comparing serum concentrations and supplement use in African‐American Caucasian patients receiving for heart failure. Design. Retrospective medical record review. Setting. Two failure centers. Patients. Fifty 67 with who were a stable dosage addition to standard therapy an angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker. Measurements Main Results. Medical...
A lifesaving treatment for myocardial infarction is the placement of a stent in closed or obstructed coronary artery. The largest modifiable risk factor after receiving medication adherence to Dual AntiPlatelet Therapy, combination P2Y12 inhibitors and aspirin.
Background: Antiplatelet therapy with aspirin and a thienopyridine is the standard of care for prevention thrombosis following coronary stent implantation. Recent evidence suggests prolonged risk thrombosis; therefore, clopidogrel at least 1 year recommended implantation drug-eluting stent. Premature discontinuation well-recognized factor thrombosis. Objective: To identify rate adherence to among patients who have undergone percutaneous intervention (PCI). Methods: We queried central Veteran...
Evidence of racial differences in aldosterone concentrations and K+ disposition suggests that response to antagonism might vary by race. The authors sought determine whether spironolactone differs between African Americans Caucasians with heart failure. Heart failure patients African‐American (n=34) or Caucasian (n=17) race were started on 12.5 mg/d, up‐titration as tolerated. Laboratory values drug therapy similar groups at baseline. Spironolactone was titrated a median dose 25 mg/d both...
Prolongation of the corrected QT interval can lead to deadly arrhythmia torsades de pointes. There are many risk factors for prolongation, one being medication. The goal this case report is add limited literature surrounding possibility pointes when levofloxacin and fluconazole used concomitantly. Additionally, provide guidance patient that need be assessed prescribing two drugs.
Atrial fibrillation (AF) increases the risk of stroke and direct oral anticoagulants (DOACs) are first-line agents for prevention. Gaps in literature cause reluctance prescribing DOACs patients with renal dysfunction and/or extremes body weight.To evaluate impact weight function have on major clinically relevant nonmajor (CRNM) bleeding events ischemic strokes AF receiving a DOAC.This retrospective cohort study included adults nonvalvular atrial (NVAF) or flutter (AFL) DOAC ≥12 months. The...
Cardiac fibrosis plays an important role in the pathophysiology of heart failure. The authors sought to determine whether biomarkers cardiac for milder clinical degrees failure are comparable those more advanced disease. Procollagen types I and III amino‐terminal peptides (PINP PIIINP) type collagen telopeptide (ICTP) were compared between aldosterone‐antagonistnaive patients with New York Heart Association class or II (n=22/23) IV (n=42/3) symptoms. Median (interquartile) range...
To determine whether beta-blocker dose influences cardiac collagen turnover and the effects of spironolactone on in patients with heart failure.Prospective clinical study.Two failure centers.Eighty-eight spironolactone-naïve who were taking beta-blockers.In a subset 29 patients, was started at 12.5 mg/day, dosage titrated to 25 mg/day if tolerated.Venous blood samples collected from each patient. Serum procollagen type I III aminoterminal peptides (PINP PIIINP) determined by radioimmunoassay...
While it is known that patients with moderate or severe tricuspid regurgitation (TR) are at a higher risk of adverse events following transcatheter aortic valve replacement (TAVR), the impact mild TR less well understood. We aimed to further investigate relationship between and outcomes among undergoing TAVR our center. A retrospective study was conducted major academic center on from 2018-2022. Patients were placed into 2 groups: those without/trivial (WTR) (MTR). excluded moderate/severe...