A5001702901- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- MRI in cancer diagnosis
- Urinary Bladder and Prostate Research
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemodynamic Monitoring and Therapy
- Surgical Simulation and Training
- Atomic and Subatomic Physics Research
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Endometrial and Cervical Cancer Treatments
- Medical Imaging and Analysis
- Soft Robotics and Applications
- Multiple and Secondary Primary Cancers
- Cerebrovascular and Carotid Artery Diseases
Heidelberg University
2021-2024
University Hospital Heidelberg
2021-2024
University Medical Center Utrecht
2019-2024
Cancer Genomics Centre
2022
Utrecht University
2022
MRI-guidance may aid better discrimination between Organs at Risk (OARs) and target volumes in proximity of the mediastinum. We report first clinical experiences with Stereotactic Body Radiotherapy (SBRT) (ultra)central lung tumours on a 1.5 T MR-linac.
Online adaptive MR-guided treatment planning workflows facilitate daily contour adaptation to the actual anatomy. Allocating radiation therapists (RTTs) instead of oncologists (ROs) might allow for increasing workflow efficiency. This study investigates conformity adapted target contours provided by dedicated RTTs and ROs.In a simulated online procedure, 6 ROs recontoured targets organs at risk (OAR) in prostate cancer (n = 2), rectal 2) lymph node-oligometastases cases. gained contouring...
Radiorecurrent prostate cancer is conventionally confirmed using systematic and/or targeted biopsies. The availability of multiparametric (mp) MRI and specific membrane antigen (PSMA) PET/CT has increased diagnostic accuracy. objective was to determine the positive predictive value (PPV) combined mp-MRI PSMA whether pathology verification with MR-targeted biopsies remains necessary for patients radiorecurrent cancer. Patients locally recurrent who were referred 19 Gy single-dose MRI-guided...
Manual contouring of neurovascular structures on prostate magnetic resonance imaging (MRI) is labor-intensive and prone to considerable interrater disagreement. Our aim contour automatically MRI by deep learning (DL) improve workflow agreement.Segmentation was performed pre-treatment 3.0 T data 131 cancer patients (training [n = 105] testing 26]). The include the penile bulb (PB), corpora cavernosa (CCs), internal pudendal arteries (IPAs), bundles (NVBs). Two DL networks, nnU-Net DeepMedic,...
This R-Ideal stage 1b/2a study describes the workflow and feasibility of long-course fractionated online adaptive MR-guided chemoradiotherapy with reduced CTV-to-PTV margins on 1.5T MR-Linac for patients esophageal cancer.Patients cancer scheduled to undergo chemoradiation were treated a MR-Linac. Daily MR-images acquired contour adaptation replanning. Contours manually adapted match daily anatomy an isotropic margin 6 mm was applied. Time recorded all individual steps in workflow....
Radiation damage to neural and vascular tissue, such as the neurovascular bundles (NVBs) internal pudendal arteries (IPAs), during radiotherapy for prostate cancer (PCa) may cause erectile dysfunction. Neurovascular-sparing magnetic resonance-guided adaptive (MRgRT) aims preserve function after treatment. However, NVBs IPAs are not routinely contoured in current practice. Before neurovascular-sparing MRgRT PCa can be implemented, interrater agreement of contouring on pre-treatment MRI needs...
Patients who are surgically treated for stage I to III non-small cell lung cancer (NSCLC) have dismal prognosis after incomplete (R1-R2) resection. Our study aimed develop a prediction model estimate the chance of resection based on preoperative patient-, tumor-, and treatment-related factors.From Dutch national database, NSCLC patients had surgical treatment without neoadjuvant therapy were selected. Thirteen possible predictors analyzed. Multivariable logistic regression was used create...
A robotic needle implant device for MR-guided high-dose-rate (HDR) prostate brachytherapy was developed. This study aimed to assess the feasibility and spatial accuracy of HDR using device, a single intraprostatic target point.
We appreciate the comments made by Grivas et al regarding our article on automated contouring of neurovascular structures prostate MRI [[1]van den Berg I. Savenije M.H.F. Teunissen F.R. van de Pol S.M.G. Rasing M.J.A. Melick H.H.E. al.Deep learning for magnetic resonance imaging cancer patients.Phys Imaging Radiat Oncol. 2023; 26100453https://doi.org/10.1016/j.phro.2023.100453Abstract Full Text PDF Scopus (1) Google Scholar]. are thankful recognizing potential artificial intelligence model...
Irradical (R1-2) resection for non-small cell lung cancer (NSCLC) is associated with a dismal prognosis. Adjuvant treatment attempts to improve survival outcomes, but evidence on the optimal strategy limited. The purpose of this study was compare overall (OS) between different adjuvant strategies in these patients. Out 8,528 patients newly diagnosed NSCLC from 2015-2018, those an R1-2 were identified Netherlands Cancer Registry. First, OS compared groups 'no therapy', 'radiotherapy (RT)...
Irradical resection of non-small-cell lung cancer (NSCLC) is a detrimental prognostic factor. Recently, Rasing et al. presented an internationally validated risk score for pre-treatment prediction irradical resection. We hypothesized that chemoradiation therapy (CRT) could serve as alternative approach in patients with high and compared overall survival (OS) outcomes between surgery CRT.Patients from population-based cohort stage IIB-III NSCLC 2015 2018 The Netherlands were selected....