A5068000449- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Cardiovascular Effects of Exercise
- Cancer Treatment and Pharmacology
- Advanced MRI Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- GDF15 and Related Biomarkers
- Biochemical and Molecular Research
- Bone fractures and treatments
- Parkinson's Disease Mechanisms and Treatments
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- HIV-related health complications and treatments
University Hospitals Bristol NHS Foundation Trust
2022
University Hospitals Bristol and Weston NHS Foundation Trust
2022
University of Bristol
2019-2022
Bristol Royal Infirmary
2022
NIHR Bristol Cardiovascular Biomedical Research Unit
2019-2021
Interbalkan Medical Center
2021
Birmingham City Hospital
2013
University of Birmingham
2013
Democritus University of Thrace
2008-2010
University Radiology
2008
Studies have suggested that collagen accumulation in the aortic wall may contribute to stiff aorta arterial hypertension. However, data human hypertension are limited. In this investigation, relations between markers of metabolism and function patients with were evaluated.We studied 72 hypertensive (age 53 +/- 5 years) 27 age- gender-matched normotensive individuals. Elastic properties assessed by pulse wave velocity (carotid-to-femoral (PWVc-f)). Free amino-terminal propeptides precollagen...
Studies have shown that erythrocyte membranes are present within necrotic cores in atherosclerotic plaques, and circulating erythrocytes patients with acute coronary syndrome (ACS) increased total cholesterol content (CEM). Interleukin-8 (IL-8) binds to during intraplaque haemorrhage it is released into the plaque thus may contribute inflammatory cascade instability. The study was undertaken test hypothesis membrane IL-8 elevated ACS compared those chronic stable angina (CSA). Consecutive...
Altered myocardial extracellular matrix turnover has been proposed as a major determinant of remodelling. Carboxy-terminal telopeptide collagen type-I (CITP) represents degradation-derived serum peptide. In this study we examined the independent and additive prognostic value concentrations CITP compared with well-known mortality predictors such N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) patients.We studied 196 consecutive patients (126 male, mean age...
It has been estimated that 20–30% of repaired aortic coarctation (CoA) patients develop hypertension, with significant cardiovascular morbidity and mortality. Vertebral artery hypoplasia (VAH) an incomplete posterior circle Willis (ipCoW; VAH + ipCoW) is associated increased cerebrovascular resistance before the onset sympathetic nerve activity in borderline hypertensive humans, suggesting brainstem hypoperfusion may evoke hypertension to maintain cerebral blood flow: "selfish brain"...
Objectives Presence of free cholesterol in atherosclerotic plaques is a major determinant plaque instability. It hypothesized that extravasated erythrocytes may contribute to accumulation through their rich membrane. In this study we assessed whether erythrocyte membranes (CEMs), is, (FCEM) versus esterified (ECEM), differs patients with chronic stable angina (CSA) compared presenting acute coronary syndromes (ACSs). Methods Consecutive were prospectively assessed; 154 had CSA (118 men, 63...
Variants in the posterior anatomy of cerebral circulation are associated with hypertension and lower blood flow midlife (age ≈55 years); however, whether these variants a result aging or long-term exposure to high pressure is unclear. Additionally, role play early onset (<40 years) poor perfusion this population unknown.We retrospectively examined specific cerebrovascular (vertebral artery hypoplasia absent/hypoplastic communicating arteries (an incomplete circle Willis) measured via...
Myocardial collagen content as a fundamental component of extracellular matrix, is altered in pathological states including heart failure (HF). Serum peptides related to myocardial synthesis and degregation can be measured may used indices turnover. The present study was undertaken assess the hypothesis that resolution acute decompensation chronic HF associated with changes serum degregation.Serum concentrations amino-terminal propetide procollagen type I (PINP) carboxy-terminal telopeptide...
Bicuspid aortic valve (BAV) patients develop ascending (AAo) dilation. The pathogenesis of BAV aortopathy (genetic vs. haemodynamic) remains unclear. This study aims to identify regional changes around the AAo wall in with aortopathy, integrating molecular data and clinical imaging. (n = 15) were prospectively recruited surgically collect tissue measure markers across circumference. Dilated (anterior/right) non-dilated (posterior/left) circumferential segments profiled for whole-genomic...
Pulmonary artery aneurysms are a rare but often fatal clinical entity with an estimated incidence of 1 in 14,000 individuals postmortem studies. They can be congenital or acquired. No specific guidelines regarding their optimal management, medical surgical, currently exist and treatment is planned on case-by-case basis since data course prognosis limited. We present the case 77-year-old male patient who presented at Emergency Department our hospital complaint exertional dyspnea dull...
<h3>Introduction</h3> Synchronised DC cardioversion is a commonly used treatment option for persistent atrial fibrillation (AF). Atrial distension predisposing factor AF, and fibrosis of the myocardium may prevent remodelling atrium to normalised parameters following cardioversion, with fibrotic begetting inevitable recurrence AF. <h3>Methods</h3> We retrospectively investigated echocardiographic appearances 89 patients prior elective determine whether simple measurements dimensions in...
A 68-year-old male was referred for a stress perfusion MRI new onset of atypical chest pain.Past medical history included inferior myocardial infarction and coronary artery bypass grafting 15 years before.A standard protocol CMR performed with short-and longaxis cines, adenosine rest first-pass perfusion, early late gadolinium enhancement.Images showed normal indexed LV volumes hypokinesia the wall.The right ventricle systolic function.There no evidence any inducible defect on stress.After...