Zhen Zhang

ORCID: 0000-0003-1361-408X
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About
Contact & Profiles
Research Areas
  • Hip and Femur Fractures
  • Cardiac, Anesthesia and Surgical Outcomes
  • Congenital gastrointestinal and neural anomalies
  • Spinal Fractures and Fixation Techniques
  • Infectious Diseases and Tuberculosis
  • Anesthesia and Pain Management
  • Pelvic floor disorders treatments
  • Orthopaedic implants and arthroplasty
  • Spine and Intervertebral Disc Pathology
  • Orthopedic Infections and Treatments
  • Congenital Anomalies and Fetal Surgery
  • Pediatric Hepatobiliary Diseases and Treatments
  • Pelvic and Acetabular Injuries
  • Gallbladder and Bile Duct Disorders
  • Knee injuries and reconstruction techniques
  • Helicobacter pylori-related gastroenterology studies
  • Intestinal Malrotation and Obstruction Disorders
  • Nausea and vomiting management
  • Shoulder Injury and Treatment
  • Bone fractures and treatments
  • Escherichia coli research studies
  • Total Knee Arthroplasty Outcomes
  • Pancreatic function and diabetes
  • Musculoskeletal Disorders and Rehabilitation
  • Urological Disorders and Treatments

Ningxia Medical University
2024-2025

Renji Hospital
2024

Shanghai Jiao Tong University
2024

West China Hospital of Sichuan University
2021-2023

Capital Institute of Pediatrics
2015-2023

Hospital for Sick Children
2023

Henan Provincial People's Hospital
2014-2023

Zhengzhou Central Hospital
2023

Sichuan University
2021-2023

Xiangya Hospital Central South University
2020-2022

The femoral neck system (FNS) may be a valid alternative for treating fractures, but few studies have compared the outcomes between FNS and cannulated cancellous screws. This study aimed to compare clinical efficacy complications of with those inverted screws (ICCS) treatment fractures in adults.This retrospective evaluated patients who underwent or ICCS internal fixation June 2019 January 2020. operative time, intraoperative blood loss, number fluoroscopies, length surgical incision,...

10.1186/s13018-021-02659-0 article EN cc-by Journal of Orthopaedic Surgery and Research 2021-08-16

The aim of this study was to compare clinical outcomes patients with femoral neck fractures treated the dynamic hip system blade (DHS-BLADE) or cannulated compression screws.Eighty-six were by closed reduction internal fixation a DHS-BLADE (n = 42; 18 males and 24 females; mean age: 56.3 years (37-87)) screws 44; 20 53.8 (26-83)) between March 2011 August 2013. groups compared Harris score, operation time, surgical blood loss, incision size, hospital stay, related complications.The average...

10.1016/j.aott.2017.07.006 article EN cc-by-nc-nd Acta Orthopaedica et Traumatologica Turcica 2017-08-26

Abstract Background Helicobacter pylori ( H. ) causes chronic gastric disease. An efficient oral vaccine would be mucosa-targeted and offer defense against colonization of invasive infection in the digestive system. Proteolytic enzymes acidic environment gastrointestinal tract (GT) can, however, reduce effectiveness vaccinations. For creation an edible vaccine, L. lactis has been proposed as a means delivering antigens. Results We developed plSAM (pNZ8148-SAM) that expresses multiepitope...

10.1186/s12934-024-02321-4 article EN cc-by Microbial Cell Factories 2024-02-24

Helicobacter pylori (H. pylori), a specific bacterium capable of surviving in the acidic environment stomach, has been recognized as group causative agents gastric cancer. Therefore, development mucosal vaccines against H. is expected to provide an important direction for treatment chronic gastritis and prevention In this study, we used bacteria-like particles (BLPs) obtained by treating Lactic acid bacteria (L. lactis) with hot acid, successfully displayed M cell-targeted multi-epitope...

10.1186/s12951-025-03111-9 article EN cc-by-nc-nd Journal of Nanobiotechnology 2025-01-18

This retrospective study evaluated the efficacy, opioid consumption, and safety profile of two patient-controlled intravenous analgesia (PCIA) regimens (sufentanil combined with nalbuphine vs sufentanil alone) after cesarean section (CS).Parturients (n = 1808) received (SN group) or alone (S as PCIA CS. The primary outcome was numeric rating scale (NRS) pain score movement (NRS-M) at 24 h Secondary outcomes were NRS scores rest (NRS-R) 48 CS, NRS-M cumulative bolus times, consumption during...

10.2147/dddt.s380292 article EN cc-by-nc Drug Design Development and Therapy 2022-10-01

Objective The aim of this study was to define controlled outcomes for bowel function and quality life (QoL) after transanal rectal mucosectomy partial internal anal sphincterectomy pull-through (TRM-PIAS, A modified Swenson procedure) Hirschsprung disease (HD). Background We have previously shown that a novel modification the advantage low postoperative associated enterocolitis. long-term follow-up studies evaluating Bowel Function Score (BFS) Pediatric Quality Life Inventory (PedsQoL, age...

10.3389/fped.2023.1099606 article EN cc-by Frontiers in Pediatrics 2023-02-14

Existing statistical data indicates that an increasing number of people now require rehabilitation to restore compromised physical mobility. During the process, therapists evaluate and guide movements patients, aiding them in a more effective recovery preventing secondary injuries. However, immutability mobility expensive price training hinder some patients from timely access rehabilitation. Utilizing virtual reality for might offer potential alleviation these issues. prevalent pose...

10.3389/fnins.2024.1388742 article EN cc-by Frontiers in Neuroscience 2024-04-04

This retrospective study aimed to determine the feasibility and efficacy of endoscopy-assisted anterior cervical debridement combined with posterior fixation fusion in patients upper spine tuberculosis.Between June 2008 January 2016, 17 (10 men 7 women) tuberculosis underwent fusion. Anti-tuberculosis treatment was administered for 2-4 weeks preoperatively 12-18 months postoperatively. The clinical radiographic data were analyzed.The operation successfully completed all patients. Neck pain...

10.1186/s12891-022-05084-4 article EN cc-by BMC Musculoskeletal Disorders 2022-02-08

This paper presents a novel method for tracking and characterizing adherent cells in monolayer culture. A system of cell employing computer vision techniques was applied to time-lapse videos replicate normal human uro-epithelial cultures exposed different concentrations adenosine triphosphate (ATP) selective purinergic P2X antagonist (PPADS), acquired over 24 h period. Subsequent analysis following feature extraction demonstrated the ability technique successfully separate modulated classes...

10.1016/j.biosystems.2016.05.009 article EN cc-by Biosystems 2016-06-03

In recent years, the incidence of colorectal cancer (CRC) has increased annually, which seriously threatened health and quality life patients. treatment CRC, both laparoscopic radical resection are widely used.To explore discuss clinical efficacy postoperative inflammatory response open CRC.A total 96 patients with CRC diagnosed in our hospital from March 2016 to April 2021 were selected, divided into study group (n = 48) control using a simple random method. The was treated CRC....

10.12998/wjcc.v10.i13.4042 article EN World Journal of Clinical Cases 2022-04-29

Abstract Background The use of a tourniquet during high tibial osteotomy (HTO) is routine procedure, but there currently no research on the benefits and potential risks HTO. aim this study was to investigate impact perioperative blood loss, early functional recovery complications in opening wedge HTO with modern tranexamic acid protocols. Methods This retrospective cohort patients who underwent unilateral between January 2019 September 2020. All were divided into two groups according whether...

10.1186/s12891-021-04830-4 article EN cc-by BMC Musculoskeletal Disorders 2021-11-08

The acidic environment and enzyme degradation lead to oral vaccines often having little immune effect. Therefore, it is an attractive strategy study effective safe vaccine delivery system that can promote gastrointestinal mucosal responses inhibit antigen degradation. Moreover, the antigens uptake by microfold cells (M cells) determining step in initiating efficient responses. M cell-targeting one promising approach for enhancing potency. In present study, L. lactis surface display (plSAM)...

10.1007/s00253-024-13070-0 article EN cc-by Applied Microbiology and Biotechnology 2024-02-23

Femoral neck fracture is a common in orthopedic practice. This study aimed to compare the clinical outcomes between femoral system and dynamic hip blade for treatment of young patients.This retrospective included 43 52 patients who underwent with blade, respectively, August 2019 2020. Operative indexes, including operation duration, blood loss, incision length, postoperative complications (femoral shortening, non-union, screw pull-out, head necrosis), Harris scale scores were recorded...

10.3389/fsurg.2023.1092786 article EN cc-by Frontiers in Surgery 2023-02-03

Abstract Background Rotator cuff injuries, which cause health problems especially in athletes and older adults, may be linked to factors like age, overuse, muscle imbalance, potentially, certain shoulder joint shapes, though the impacts of Critical Shoulder Angle (CSA) Lateral Acromion (LAA) are still unclear. The aim this study was explore correlation between individual anatomical structure scapula rotator injuries. Methods A total 71 patients suffering from ailments were examined, with 40...

10.21203/rs.3.rs-3085852/v1 preprint EN cc-by Research Square (Research Square) 2023-07-18
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