Juan Francisco Gutiérrez‐Bautista
A5055415950- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- COVID-19 and Mental Health
- interferon and immune responses
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Migration, Health and Trauma
- Vector-borne infectious diseases
- Complement system in diseases
- Renal Transplantation Outcomes and Treatments
- Public Health and Environmental Issues
- Dermatological diseases and infestations
- vaccines and immunoinformatics approaches
- PARP inhibition in cancer therapy
- Genomics, phytochemicals, and oxidative stress
Hospital Universitario Virgen de las Nieves
2020-2025
Universidad de Granada
2021-2025
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2025
Instituto de Investigación Biosanitaria de Granada
2022-2024
The severity of SARS-CoV-2 infection has been related to uncontrolled inflammatory innate responses and impaired adaptive immune mostly due exhausted T lymphocytes lymphopenia. In this work we have characterized the nature lymphopenia demonstrate a set factors that hinder effective control virus activation arming effector cytotoxic CD8 cells showing signatures defining high-risk population. We performed profiling helper (Th) CD4+ CD8+ cell compartments in peripheral blood 144 COVID-19...
In this study, we have compared the detection of IgM and IgG against C. burnetii phase II an enzyme-linked immunosorbent assay (ELISA) (Euroimmun) a chemiluminescent immunoassay (CLIA) (VIRCLIA, Vircell). addition, indirect immunofluorescence (IFA) was used as reference test. One hundred forty-eight sera were for evaluation, eighty-eight IgM. The sensitivity ELISA CLIA in detecting excellent. On other hand, showed better specificity than As IgG, similar, while technique higher sensitivity....
Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially the development of acquired immunity. Given high degree polymorphisms that HLA molecules present, some will be more or less effective controlling SARS-CoV-2 infection. We wanted analyze whether certain may involved protection susceptibility COVID-19. studied class I (HLA-A, -B and -C) II (HLA-DRB1 HLA-DQB1) 450 patients who required hospitalization for COVID-19, creating one largest HLA-typed...
The vaccines designed against the SARS-CoV-2 coronavirus are based on spike (S) protein. Processing of S protein by antigen-presenting cells (APC) and its subsequent presentation to T is an essential part development a humoral response. HLA-class II alleles considered immune response genes because their codified molecules, expressed surface APCs (macrophages, dendritic, B cells) present antigenic peptides cell via receptor (TCR). highly polymorphic, regulating what specific induce follicular...
Rapid and accurate diagnosis of mycobacterial infections is crucial for guiding therapeutic decisions. This study presents the first evaluation a novel molecular assay, Mycobacterium RealTime PCR Kit Vircell (MRTVircell), real-time PCR-based test designed specific detection tuberculosis complex (MTBC), avium (MAC), abscessus (MABC), other nontuberculous mycobacteria (NTM) in both respiratory non-respiratory samples. The was conducted under routine workflow conditions using 721 clinical...
The COVID-19 pandemic highlighted the importance of effective vaccination strategies in controlling spread infectious diseases. SARS-CoV-2 vaccine has demonstrated high efficacy preventing infection general population. However, this patients with predominantly antibody deficiencies, such as common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA), should be closely monitored. CVID XLA are rare genetic disorders that impair immune system's ability to produce antibodies,...
Background: Antibody-mediated rejection (AMR) is one of the most important challenges in context renal transplantation, because binding de novo donor-specific antibodies (dnDSA) to kidney graft triggers activation complement, which turn leads loss transplant. In this context, objective study was evaluate association between complement-fixing dnDSA and as well possible non-complement-fixing transplanted organ survival transplant recipients. Methods: Our included a cohort 245 patients over...
In August 2020, anew West Nile virus (WNV) outbreak affected 71 people with meningoencephalitis in Andalusia (Spain). Samples from these individuals were received our laboratory, a regional Virus Referral Centre. The aim of this study was to compare the agreement, sensitivity and specificity findings between WNV VIRCLIA IgG IgM assay (Vircell, Spain) ELISA (Euroimmun, Germany) performance Euroimmun for cerebrospinal fluid (CSF) diagnosis. included 24 CSF samples (paired serum samples) 247...
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania, which endemic in certain areas Europe, such as southern Spain. The manifests various clinical phenotypes, including visceral, cutaneous, mucosal, or asymptomatic leishmaniasis. This diversity outcomes may be influenced host immune response, with human leukocyte antigen (HLA) molecules playing a crucial role determining susceptibility and progression infection. study explores association between specific HLA...
Common variable immunodeficiency (CVID) is an antibody with a wide variety of clinical and immunological manifestations, whose genetic cause found in about 25% diagnosed cases. Giardia lamblia one the main causes gastrointestinal infections CVID. 5-Nitroimidazoles are most used first-line treatment, but nitroimidazole-refractory giardiasis increasing. Nevertheless, only few cases refractory CVID have been reported. This study aimed to determine incidence infection our cohort, shows...
The new vaccines against SARS-CoV-2 have raised a lot of expectations about their ability to induce immunity and the duration this. This is case mRNA such as Moderna's mRNA-1273. Therefore, it necessary study humoral cellular generated by these vaccines. Our objectives are determining what normal response antibody production, level protective antibodies monitoring patients in subsequent infection with COVID-19. We present first results longitudinal 601 health workers vaccinated Moderna. show...
The genetic basis of severe COVID-19 has been thoroughly studied and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted largest GWAS meta-analysis for hospitalization admixed Americans, comprising a total 4,702 hospitalized cases recruited by other seven participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a GWAS for hospitalization admixed Americans, comprising total 4,702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We identified four genome-wide...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
The SARS-CoV-2 disease presents different phenotypes of severity. Comorbidities, age, and being overweight are well established risk factors for severe disease. However, innate immunity plays a key role in the early control viral infections may condition gravity COVID-19. Natural Killer (NK) cells part important virus infection by killing infected participating development adaptive immunity. Therefore, we studied short tandem repeat (STR) transmembrane polymorphisms major histocompatibility...
Abstract The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a GWAS for hospitalization admixed Americans, comprising total 4,702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We identified four...