A5008505542- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Viral Infections and Vectors
- X-ray Diffraction in Crystallography
- Computational Drug Discovery Methods
- Catalytic C–H Functionalization Methods
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Electron Spin Resonance Studies
- SARS-CoV-2 and COVID-19 Research
- Catalytic Alkyne Reactions
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Phytochemistry and Biological Activities
- Synthesis of Organic Compounds
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Paraquat toxicity studies and treatments
- Diverse Scientific Research Studies
- Phytochemical compounds biological activities
- Oxidative Organic Chemistry Reactions
- Prostate Cancer Treatment and Research
- Plant biochemistry and biosynthesis
- Bioactive Natural Diterpenoids Research
National Research Institute of Chinese Medicine
2014-2025
Ministry of Health and Welfare
2014-2025
National Taiwan University
2010
China Medical University
2010
National Yang Ming Chiao Tung University
2010
National Defense Medical Center
1997
Six hexacyclic triterpene acids (1−6), named euscaphic A−F, and eight known acid compounds (7−14) were isolated from an ethanolic extract of twigs Euscaphis japonica. Compounds 8 10 for the first time a natural source. Triterpenes 1−6 possess skeletons with 13α,27-cyclopropane ring. Structural elucidation was established by spectroscopic methods, especially 2D NMR techniques (1H−1H COSY, HMQC, HMBC, NOESY). 3, 4, 14 showed significant cytotoxicity against different cancer cell lines [IC50 =...
Traditional herbal medicine offers opportunities to discover novel therapeutics against SARS-CoV-2 mutation. The dried aerial part of mint (Mentha canadensis L.) was chosen for bioactivity-guided extraction. Seven constituents were isolated and characterized by nuclear magnetic resonance (NMR) mass spectrometry (MS). Syringic acid methyl rosmarinate evaluated in drug combination treatment. Ten amide derivatives synthesized, the dodecyl (13) 3-ethylphenyl (19) demonstrated significant...
This study explores the potential anti-H1N1 Influenza A activity of bioactive compounds extracted from Streptomyces ardesiacus, a marine-derived microorganism known for producing diverse secondary metabolites. Four major compounds—1-acetyl-β-carboline, 1H-indole-3-carbaldehyde, anthranilic acid, and indole-3-carboxylic acid—were isolated characterized through NMR. Among these, identified structure 1-acetyl-β-carboline showed highest IC50 effect, with dose 9.71 μg/mL in anti-influenza assays....
Bioassay-guided isolation of Mimosa diplotricha led to the four new 5-deoxyflavones, diplotrins A–C (1–3) and diplotasin (4), together with 12 known flavonoids, flavonolignans, triterpenoids. On basis spectroscopic evidence, compounds 1–4 were characterized as 2′,5′-dihydroxy-3,7,8,4′-tetramethoxyflavone (1), 3′-hydroxy-3,7,8,4′-tetramethoxyflavone (2), 2′-hydroxy-7,4′,5′-trimethoxyflavone (3), 4-hydroxy-3,10,11-trimethoxyisochromeno-[4,3-b]-chromen-7(5H)-one (4). The cytotoxic effects these...
Liu Jun Zi Tang (LJZT) has been used to treat functional dyspepsia and depression, suggesting its effects on gastrointestinal neurological functions. LJZT is currently as a complementary therapy attenuate cisplatin-induced side effects, such dyspepsia. However, effect chemotherapy-induced neuropathic pain or neurotoxicity rarely studied. Thus, we explored potential mechanisms underlying protection against neurotoxicity. We observed that attenuated thermal hyperalgesia in mice apoptosis human...
Huang Lian Jie Du Tang (HLJDT) is a traditional Chinese medical decoction for heat-fire clearing and detoxication. Theoretically, the cause of Parkinson's disease (PD) has been attributed to dysregulations internal wind, phlegm, fire, stasis. Thus, HLJDT used treat PD. However, molecular mechanism unknown. Besides, paraquat (PQ) as an herbicide known impair midbrain dopaminergic neurons, resemblance pathology in treating PD PQ-induced vitro model was investigated this study. Primarily,...
Four new anthraquinones, 1,6-dihydroxy-2-methoxymethylanthraquinone (<b>1</b>), 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone (<b>3</b>), 3,6-dihydroxy-7-methoxy-2-methylanthraquinone (<b>4</b>), and 6-hydroxy-2-methoxymethylanthraquinone (<b>8</b>), together with 12 known anthraquinones 6 other compounds, were isolated from the EtOAc extract of <i>Morinda umbellata</i>. Among <b>1</b>, rubiadin (<b>14</b>), and, 3-hydroxy-2-hydroxymethylanthraquinone (<b>16</b>) exhibited significant...
The coronavirus disease 2019 (COVID-19) pandemic continues to represent a challenge for public health globally since transmission of different variants the virus does not seem be effectively affected by current treatments and vaccines. During COVID-19 outbreak in Taiwan, patients with mild symptoms were improved after treatment NRICM101, traditional Chinese medicine formula developed our institute. Here, we investigated effect mechanism action NRICM101 on improval COVID-19-induced pulmonary...
A novel cascade Pd(II)-catalyzed endo-dig cycloisomerization and olefination reaction of 2-benzyl-3-alkynyl chromones with activated/unactivated alkenes has been developed for the synthesis fused oxatricyclic compounds. This concise one-pot synthetic approach was applied to difunctionalization unbiased alkynes based on 2-benzyl-3-(alkynyl)-4H-chromen-4-one via O-attack cycloisomerization, followed by both activated unactivated alkenes.
Five new triterpene acids, mesonaic acids A–C (1–3), 2α,3α,19α-trihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), and 3α,19α,22α-trihydroxy-2-oxo-12-ursen-28-oic (5), 10 known compounds (6–15) were isolated from a methanolic extract of Mesona procumbens. Triterpenes 1–3 possess unusual hexacyclic skeletons with 13α,27-cyclopropane ring. Regarding their anti-inflammatory activity, 1–3, 6, 7 inhibited NO production EC50 values lower than 15 μM, which better that the positive control...
Breaking the cycle: A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone-resistant prostate cancer PC-3 cells, induced G2/M-phase arrest, and apoptosis through a caspase-dependent pathway.
A novel, highly stereoselective gold-catalyzed spirocyclization of 2-benzyl-3-alkynyl chromone with nitrone is described. This cascade reaction involves cycloisomerization, nitrone-olefin [3 + 2]-annulation, alkene oxidation, and rearrangement for the formation spirocyclic products. Interestingly, isoxazolidine ring generated from 2]-annulation donates oxygen to generate a new pyran-3(4
Abstract The metal ion chelating β‐ N ‐hydroxy‐γ‐ketocarboxamide pharmacophore was integrated into a quinazolinone scaffold, leading to ‐arylalkyl‐3‐hydroxy‐4‐oxo‐3,4‐dihydroquinazolin‐2‐carboxamide derivatives as hepatitis C virus (HCV) NS5B polymerase inhibitors. Lead optimization led the identification of ‐phenylpropyl carboxamide 9 k (IC 50 =8.8 μ M ). Compound possesses selectivity toward HCV1b replicon Ava.5 cells (EC =17.5 ) over parent Huh‐7 (CC =187.5 effects mixed mode inhibition,...
Obesity is becoming a worldwide epidemic, especially in industrialized countries. We hereby report methanolic extract of Mesona procumbens (known as Hsian-tsao Taiwan) significantly inhibits lipid accumulation 3T3-L1 adipocytes, and eight new primeverose derivatives, mesonosides A-H (1-8), were isolated from the M. procumbens. Structural elucidation 1-8 was established by spectroscopic methods, 2D NMR techniques (1H-1H COSY, HSQC, HMBC, NOESY) HRESIMS. Anti-obesity evaluation revealed that...
Mesona procumbens is a popular material used in foods and herbal medicines Asia for clearing heat resolving toxins. However, phytochemical research on this plant very rare. In study, eleven new diterpenoids, mesonols A-K (1-11), comprising seven ent-kauranes, three ent-atisanes, one sarcopetalane, were isolated from its methanolic extract. Structural elucidation of compounds 1-11 was performed by spectroscopic methods, especially 2D NMR, HRESIMS, X-ray crystallographic analysis. All isolates...