A5102008559- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Psoriasis: Treatment and Pathogenesis
- Circular RNAs in diseases
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Advancements in Transdermal Drug Delivery
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- Porphyrin Metabolism and Disorders
- Telomeres, Telomerase, and Senescence
- Lymphoma Diagnosis and Treatment
- Tryptophan and brain disorders
- Glutathione Transferases and Polymorphisms
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Histone Deacetylase Inhibitors Research
- Pharmacogenetics and Drug Metabolism
- Fungal and yeast genetics research
- Phytochemical Studies and Bioactivities
Shandong Provincial Hospital
2019-2025
Shandong University
2021-2025
Hunan University
2025
Creative Commons
2024
Weatherford College
2023
Shandong Tumor Hospital
2023
Shandong First Medical University
2023
Beijing Chao-Yang Hospital
2023
Capital Medical University
2023
Shandong Jiaotong Hospital
2018
Abstract Histone lactylation plays a crucial role in cancer progression, but its impact on breast (BC) tumorigenesis is still unclear. We utilized chromatin immunoprecipitation sequencing with H3K18la antibodies, transcriptomics of clinical BC samples, and proteomics ATAC-seq analyses vivo tumors to identify the genes regulated by transcription factor PPARD. qPCR Western blot assays were used detect expressions molecules. discovered that levels higher tissues compared adjacent non-cancerous...
Gastric cancer (GC) is the fifth most common and third leading cause of cancer-related deaths worldwide. The high mortality might be attributed to delay in detection closely related lymph node metastasis. Therefore, it great importance explore mechanism metastasis find strategies block GC Messenger RNA (mRNA), microRNA (miRNA) long non-coding (lncRNA) expression data clinical were downloaded from Cancer Genome Atlas (TCGA) database. A total 908 differentially expressed factors with variance...
Abstract An increasing number of findings have verified the critical roles circular RNAs (circRNAs) in human cancers, and chemotherapy resistance is a poor prognostic factor for breast cancer (BC). This study designed to explore function hsa_circ_0097922 tamoxifen cancer. Hsa_circ_0097922, microRNA‐876‐3p (miR‐876‐3p), alpha‐actinin 4 (ACTN4) level were detected by real‐time quantitative polymerase chain reaction (RT‐qPCR). Cell survival, proliferation, apoptosis, migration invasion Counting...
To the Editor: It has been eighteen years since telocytes (TCs) were first categorized by Popescu et al[1] in 2005. TCs classified into interstitial cells of Cajal (ICC) type based on their ultrastructure and immunohistochemical features, which are similar to mesenchymal cells.[2] In following ten years, found have own distinctive characteristics terms three-dimensional structure, immunological biomarkers, genomics, multiple functions. Interestingly, definitely distinct from fibroblasts,...
Aberrant expression and regulation of microRNAs (miRNAs) have been found in multiple cancers their dysregulation importantly contribute to the tumorigenic processes. Among these miRNAs, miRNA‐34a (miR‐34a) functions as a tumor suppressor its has reported several cancers. In this study, we investigated epigenetic biological function miR‐34a human cholangiocarcinoma cells. Our data indicate that miR‐ 34a is epigenetically silenced cells (CCLP1, SG231, Hucct1 TFK1) compared nonmalignant biliary...
This study aimed to summarize the clinical manifestations and ultrasound characteristics of primary thyroid lymphoma (PTL) explore key aspects in process diagnosing PTL.
Abstract Aberrant expression and regulation of microRNAs (miRNAs) have been found in multiple cancers their dysregulation importantly contribute to the tumorigenic processes. Among these miRNAs, miRNA-34a (miR-34a) functions as a tumor suppressor its has reported several cancers. In this study, we investigated epigenetic biological function miR-34a human cholangiocarcinoma cells. Our data indicate that is epigenetically silenced cells (CCLP1, SG231, Hucct1 TFK1) compared nonmalignant biliary...
Abstract Background: Hepatocellular carcinoma (HCC) is the main malignant tumor in humans, known for its high metastasis and lethality. However, molecular mechanisms underlying tumorigenesis HCC are still unclear. Methods: To address this, we conducted a comprehensive analysis using single nucleus RNA sequencing (snRNA-seq) assay transcriptomic technology. This approach allowed us to uncover genetic changes cancer cells other within microenvironment, leading identification of potential hub...
Background: Breast cancer is the most common which disturbs not only older population but also women under 35 years old. It ranks to be first in cancer-connected deaths of women. Objectives: Hence, we intended study investigate efficacy tomentosin as an anticancer agent against breast vitro and vivo conditions. Materials Methods: was persuaded rats by DMBA administration then treated with for 28 days. The levels estrogen receptor α (ER-α), oxidative stress markers, biotransformation enzymes,...