A5080487904- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Biochemical and Molecular Research
- Medical and Biological Sciences
- Neuroinflammation and Neurodegeneration Mechanisms
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Erythropoietin and Anemia Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism and Genetic Disorders
Neuroscience Institute
2023-2024
University of Turin
2016-2024
Abstract The Transferrin Receptor 2 (Tfr2) modulates systemic iron metabolism through the regulation of regulator Hepcidin (Hepc) and Tfr2 inactivation causes overload. Based on data demonstrating expression in brain, we analysed -KO mice order to examine molecular, histological behavioural consequences silencing this tissue. abrogation caused an accumulation specific districts nervous tissue that was not accompanied by a brain Hepc response. Moreover, Tfr2- KO presented selective...
Abstract During physiological aging, iron accumulates in the brain with a preferential distribution regions that are more vulnerable to age-dependent neurodegeneration such as cerebral cortex and hippocampus. In of aged wild-type mice, alteration Brain Blood Barrier integrity, together marked inflammatory oxidative state lead increased permeability deregulation brain-iron homeostasis. this context, we found accumulation drives Hepcidin upregulation inhibition exporter Ferroportin1. We also...
Iron is a fundamental metal involved in many cellular and biological processes all organisms, humans included. homeostasis finely regulated both systemically at the level of Central Nervous System (CNS) to avoid its imbalance; indeed, iron excess extremely toxic for cells triggers detrimental oxidative stress increase. Nevertheless, factors such as genetics, environment, aging can alter normal metabolism leading diseases, including neurodegenerative disorders Alzheimer's disease (AD). AD...
Iron is a vital element involved in plethora of metabolic activities. Mammalian systemic iron homeostasis mainly modulated by hepcidin, the synthesis which regulated number proteins, including hemochromatosis-associated proteins Hfe and Transferrin Receptor 2 (TfR2). Macrophages play versatile functions storing derived from catabolism erythrocytes supplying required for erythropoiesis. The absence macrophages causes mild deficiency aged mice leads to an overproduction exporter Ferroportin 1...
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Abstract During aging, iron accumulates in brain’s regions vulnerable to neurodegeneration: the cerebral cortex and hippocampus. However, mechanism of regulation brain remains scarce. Here, we demonstrated for first time involvement Hepcidin/Ferroportin1 pathway metabolism during aging. We alteration BBB integrity, that leads increased permeability deregulation homeostasis found overload drives Hepcidin upregulation and, consequently, inhibition exporter Ferroportin1, neuroinflammation...