A5103156776- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Renal and Vascular Pathologies
- Drug-Induced Adverse Reactions
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Pregnancy and Medication Impact
- Organ Donation and Transplantation
- Colorectal Cancer Screening and Detection
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Colorectal Cancer Surgical Treatments
- Fetal and Pediatric Neurological Disorders
- Oral health in cancer treatment
- Lipid metabolism and disorders
- RNA Interference and Gene Delivery
- Central Venous Catheters and Hemodialysis
- Celiac Disease Research and Management
- Dialysis and Renal Disease Management
- Microscopic Colitis
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Genetic and Kidney Cyst Diseases
University of Ulsan
2008-2020
Asan Medical Center
2015-2020
Ulsan College
2008-2020
Catholic University of Korea
2012
We aimed to compare disease-free survival after pulmonary metastasectomy that hepatic metastasectomy, and identify prognostic factors metastasectomy.Between 2005 2015, 129 patients underwent resection of isolated metachronous lung metastases from colorectal cancer. Three-year DFS was similar (50.7% vs. 45.5%, respectively; p=0.58). Rectal cancer (hazard ratio [HR]: 2.04, 95% confidence interval [CI]: 1.09-3.79; p=0.03) ≥2 (HR: 2.17, CI: 1.28-3.68; p=0.004) were independent adverse risk...
Abstract Background Crossmatching (XM) between organ donors and recipients is correlated with clinical outcomes. This study evaluates the results of HLA‐incompatible kidney transplant (HLA‐i KT) according to pre‐transplant XM modalities. Methods included 731 consecutive patients. HLA‐i KT was defined as a under conditions complement‐dependent cytotoxicity (CDC) positivity, flow‐cytometric (FCXM) and/or maximal donor‐specific antibody (DSA) mean fluorescence intensity (MFI) ≥5000. Results The...
The aim of this study was to investigate the changes nutritional intake and status analyze association between them during hematopoietic stem cell transplantation.This a retrospective cross sectional on 36 patients (9 Autologous transplantation group 27 Allogeneic group) undergoing at Catholic University Korea, Seoul St. Mary's Hospital from May August 2010.To assess oral parenteral nutrition intake, 24-hour recall method patient's charts review performed.Nutritional measured with scored...
Abstract Background Pneumocystis pneumonia (PCP) is a life-threatening fungal infection that can occur in kidney transplantation (KT) recipients. A growing number of KT recipients are receiving perioperative treatment with rituximab, which associated prolonged B-cell depletion and possible risk PCP occurrence; however, the optimal prophylaxis duration according to rituximab yet unknown. We compared occurrence treatment. Methods retrospectively analyzed 2110 patients who underwent between...
Abstract Background Effective gene delivery techniques are required to genetically manipulate dendritic cells (DCs). We therefore investigated the feasibility of using various self‐complementary recombinant adeno‐associated virus (scAAV) serotypes deliver genes human DCs. Methods Monocytes isolated from healthy volunteers were differentiated immature DCs (iDC) by incubation with interleukin (IL)‐4 and granulocyte macrophage colony‐stimulating factor. The iDCs transduced scAAV1, 2, 3, 4, 5, 6...
Abstract Little is known about the characteristics and clinical implications of specific subsets intragraft natural killer (NK) cells in kidney transplant recipients. We analyzed 39 for-cause renal biopsies performed at our center from May 2015 to July 2017. According histopathologic reports, 8 patients (20.5%) had no rejection (NR), 11 (28.2%) T cell-mediated rejections (TCMR) only, 20 (51.3%) antibody-mediated (ABMR). NK were defined as CD3 – CD56 + lymphocytes that are positive for CD57,...
We evaluated the oncologic outcomes of patients with rectal cancer who demonstrated pathologic near-total regression (NTR) after preoperative chemoradiotherapy (PCRT) and compared total (TR). Pathologic NTR in by tumor grade (TRG) is usually considered to indicate a good response, when evaluating response PCRT. retrospectively analyzed 263 received PCRT for advanced T3/4 or N+ followed radical resection. Patients were diagnosed TR (n = 132) 131) according TRG. Recurrence-free survival (RFS)...
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent noninvasive method to estimate the severity allograft fibrosis.We prospectively collected urine specimens from 18 deceased donor transplant recipients at 1-day, 7-day, 1-month, 3-month, and 6-month posttransplant. In addition, tissue 0-day posttransplant were sampled analyze correlation fibrosis.Thirteen had...
BACKGROUND:Patients receiving ABO-incompatible (ABOi) or human leukocyte antigen (HLA)-incompatible (HLAi) kidney transplantation (KT) require potent immunosuppression and are thus at a higher risk of infectious complications. We evaluated the clinical outcomes KT stratified by ABO HLA incompatibilities identified factors associated with outcomes. MATERIAL AND METHODS:Recipients who underwent living-related between 2012 2017 were included classified into 4 groups: ABO-compatible...
[b]BACKGROUND[/b] Kidney donors may be at increased risk for end-stage renal disease (ESRD) as well cardiovascular and all-cause mortality. In particular, data on long-term safety after kidney donation in Asian populations are lacking. We aimed to assess the of live Korean by using a matched control group. [b]MATERIAL AND METHODS[/b] conducted retrospective cohort study hospital-based database (Asan Medical Center, Seoul, Korea) group from national health insurance claims South Korea....
Abstract ABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM KT based on ABO incompatibility. We used data from Korea Organ Transplantation Registry, a nationwide database, single-center registry. A total of 263 patients with were divided into an compatible (ABOc) & (ABOc/XM+, n = 176) group ABOi (ABOi/XM+, 87) group. overall rejection rate one year after...
BACKGROUND Given that pregnancy is an immune-sensitizing event, female kidney transplant recipients who receive allografts from their offspring or husbands may have a higher risk of rejection and graft failure due to pre-sensitization acquired during childbirth. We investigated the association between donor relatedness (i.e., offspring, husband, unrelated) survival among living-donor (LDKT) with histories. MATERIAL AND METHODS From January 2009 2018, total 2060 LDKTs were performed at Asan...
This study aimed to determine whether the closure of a functioning arteriovenous (AV) access affects estimated glomerular filtration rate (eGFR) and compare outcomes according timing AV after kidney transplantation (KT). From 2009 2015, medical records were retrospectively reviewed for 142 transplant recipients (KTRs) who underwent closure. The KTRs categorized into three groups: was performed within 6 months KT in Group 1 (n = 45), at 6-12 2 49), 12-24 3 48). baseline (at time closure)...
Objectives This study describes the single center experience and long-term results of ABO incompatible kidney transplantation (ABO i KT). Methods 400 patients who received an KT in period from February 2009 to December 2016 Asan Medical Center were retrospectively reviewed. After we experienced lethal infectious complications first 89 (Era1), a pre-transplantation protocol was modified using lower dose rituximab, selective use calcineurin inhibitors anti-metabolite reduction, prophylactic...
The Luminex test can detect low levels of donor-specific antibody (DSA) that could not be detected by flow-cytometric crossmatching (FCXM) in kidney transplantation (KT). This study evaluated the impact DSA on clinical outcomes KT recipients negative FCXM. Of 575 consecutive patients who underwent living donor between January 2013 and July 2016, 494 (85.9%) were DSA-negative 81 (14.1%) DSA-positive. Although rates acute cellular rejection (ACR) at 1 year similar two groups (P = 0.54),...
Abstract Background Pneumocystis pneumonia (PCP) is a life-threatening fungal infection that can occur in kidney transplantation (KT) recipients. A growing number of KT recipients are receiving perioperative treatment with rituximab, which associated prolonged B-cell depletion and possible risk PCP occurrence; however, the optimal prophylaxis duration according to rituximab yet unknown. We compared occurrence treatment. Method retrospectively analyzed 2110 patients who underwent between...
Abstract Background Pneumocystis pneumonia (PCP) is a life-threatening fungal infection that can occur in kidney transplantation (KT) recipients. A growing number of KT recipients are receiving perioperative treatment with rituximab, which associated prolonged B-cell depletion and possible risk PCP occurrence; however, the optimal prophylaxis duration according to rituximab yet unknown. We compared occurrence treatment. Methods retrospectively analyzed 2110 patients who underwent between...
Abstract Background Pneumocystis pneumonia (PCP) is a life-threatening fungal infection that can occur in kidney transplantation (KT) recipients. A growing number of KT recipients are receiving perioperative treatment with rituximab, which associated prolonged B-cell depletion and possible risk PCP occurrence; however, the optimal prophylaxis duration according to rituximab yet unknown. We compared occurrence treatment. Method retrospectively analyzed 2110 patients who underwent between...