A5039663365- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Molecular spectroscopy and chirality
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Synthesis and Catalytic Reactions
- Molecular Sensors and Ion Detection
- Phytochemicals and Antioxidant Activities
- Fluorine in Organic Chemistry
- Analytical Chemistry and Chromatography
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal-Organic Frameworks: Synthesis and Applications
- Sleep and Wakefulness Research
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Axial and Atropisomeric Chirality Synthesis
- Organometallic Compounds Synthesis and Characterization
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Polymer Nanocomposite Synthesis and Irradiation
- Thermodynamic properties of mixtures
- Antioxidant Activity and Oxidative Stress
- Electrochemical sensors and biosensors
Gdańsk University of Technology
2012-2024
University of Gdańsk
2003-2020
Faculty (United Kingdom)
2020
Texas A&M University – Kingsville
2014-2019
University of North Carolina at Greensboro
2014
University of Connecticut
2014
Texas A&M Health Science Center
2014
Adam Mickiewicz University in Poznań
2004-2012
Northeastern University
2007-2008
University of Computer Sciences and Economics in Olsztyn
1997-2001
Cannabinoid (CB)1 receptor inverse agonists inhibit food intake in animals and humans but also potentiate emesis. It is not clear whether these effects result from agonist properties or the blockade of endogenous cannabinoid signaling. Here, we examine effect a neutral CB1 antagonist, AM4113, on intake, weight gain, Neutral antagonist binding were confirmed HEK-293 cells transfected with human CB2 receptors. AM4113 had no forskolin-stimulated cAMP production at concentrations up to 630 nM....
5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides modulation CB1: critical chain length at C3-position, an electron withdrawing group C5-position, linker between amide bond and phenyl ring B, amino substituent on B. These significantly impact binding affinity (KB) cooperativity (α). A potent CB1...
Densities of some acetonitrile solutions ionic liquids based on N-alkyl-N-methyl-morpholinium cations, N-ethyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide, N-butyl-N-methylmorpholinium N-methyl-N-octylmorpholinium bis(trifluoromethanesulfonyl)imide and N-decyl-N-methylmorpholinium were measured at T = (298.15–318.15) K atmospheric pressure. From density data the apparent molar volumes partial ILs infinite dilution as well limiting expansibilities Hepler's constant values have...
The crystal structures of five compounds capable forming self-complementary hydrogen bonds but crystallizing as catemers or creating more complex were compared with those their complexes prepared by cocrystallization perfluoroaryl compounds. results X-ray diffraction revealed that in all the cases, π–π stacking interactions caused reorganization and induced creation expected bond dimeric motifs. point to potential aryl–perfluoroaryl for control molecular self-assembly aromatic able form...
Several N-nitrosopiperidines with chirality solely due to a hindered rotation about the N−N bond were resolved enantiomers by inclusion crystallization optically active diols (TADDOLs). The absolute configuration of guest nitrosamines was deduced from X-ray crystal structures complexes. enclathrated liberated competitive complexation host piperazine. optical activity is manifested their CD spectra. A simple rule proposed for rationalization observed Cotton effect sign corresponding n−π*...
Cocrystals of seven star-shaped triaryl compounds with pentafluorophenol (pfp) were prepared and structurally characterized by the single-crystal X-ray diffraction method. Cocrystallization pfp planar (or almost planar) gave six 3:1 molecular complexes well-defined layered structures. The layers are composed alternating pfp3 trimers, linked hydrogen bonding, molecules held together in planes weak C–H···F interactions. Stacking interactions triaryl-substituted perfluorinated rings responsible...
Experimental and theoretical data on the cooperation of hydrogen chalcogen bonds in chalcogenadiazolecarboxylic acids is presented.
Planar chiral dianthranilide (1) was resolved to enantiomers with use of (-)-(1S,4R)-camphanoyl chloride as a derivatizing agent. The (+)-1 enantiomer assigned the S absolute configuration from X-ray crystal structure its N,N'-dicamphanoyl derivative. Optical resolution dithionodianthranilide (2) accomplished by inclusion crystallization (R,R)-1,2-diaminocyclohexane, and corresponding adduct revealed (-)-2stereoisomer has R configuration. A slow boat-to-boat ring inversion (DeltaG(++) = 24.1...
Several new 4-iodoethynyl- and 4,7-bis(iodoethynyl)benzo-2,1,3-chalcogenadiazoles were prepared, a comprehensive analysis of the most prominent secondary bonding interactions responsible for crystal self-assembly was performed using X-ray diffraction. The presence both iodoethynyl chalcogenadiazole moieties allows an evaluation preference these molecules to aggregate through either chalcogen- or halogen-bonding in solid state. structures compounds revealed that their solid-state arrangements...
T. Olszewska, M. J. Milewska, Połoński and Gdaniec, Chem. Commun., 1999, 1385 DOI: 10.1039/A901718F
Rational manipulation of secondary bonding interactions is a crucial factor in the construction new chalcogenadiazole-based materials. This article reports detailed experimental studies on phenanthro[9,10-c][1,2,5]chalcogenadiazolium and 2,1,3-benzochalcogenadiazolium salts their precursors. The compounds were synthesized, characterized employing NMR UV-Vis spectroscopy. TD-DFT calculations also performed. influence size aromatic system molecular motifs formed by solid state has been studied...
X-ray crystallographic analysis of the title compounds revealed that they assume a folded helical conformation an approximate C2 symmetry in solid state. Dithioamide 5b, diselenoamide 5c and monoselenoamide 5d were resolved to enantiomers by inclusion crystallization with optically active diols (TADDOLs). The absolute configuration guest molecules complexes 5b·6a, 5c·6a 5d·6a was assigned as P. optical activity is manifested their CD spectra showing relatively strong Cotton effects region...
Planar chiral N,N'-dimethyldithiodianthranilide (2b) was resolved to enantiomers through a diasteromeric complex with easily accessible silver(I) (1S)-camphorosulfonate (3). The (-)-2b enantiomer assigned the R absolute configuration from X-ray crystal structure of silver complex. compound is configurationally stable and its racemization occurs boat-to-boat ring inversion (DeltaG(double dagger) = 36.5 +/- 0.2 kcal mol(-1) at 438 K). analysis CD spectrum title showed that n-pi* Cotton effect...
Inclusion complexation of diaryl dichalcogenides with either cholic acid or chiral diols results in their helicity discrimination and an induction optical activity that can be detected by solid-state CD measurements.
The influence of ligand chirality on the self-assembly and spectroscopic properties copper(<sc>i</sc>) halide coordination polymers was investigated.
Some inverse agonists of cannabinoid receptor type 1 (CB<sub>1</sub>) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation CB<sub>1</sub> agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, are centrally active, with a high level psychiatric side effects. Hence, discovery chemical scaffold distinct from these holds promise for developing peripherally active fewer We generated new agonist,...
Lactams 1–3 readily form cocrystals with pentafluorophenol ( pfp ) or pentafluorobenzoic acid pfba and the observed crystal packings result from concerted aryl⋯perfluoroaryl stacking interactions combined hydrogen bonding.