A5100420814- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Sepsis Diagnosis and Treatment
- Spinal Hematomas and Complications
- Shoulder Injury and Treatment
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Nausea and vomiting management
- Spinal Fractures and Fixation Techniques
- Hip and Femur Fractures
- Pain Management and Treatment
- Cell death mechanisms and regulation
- Cancer Treatment and Pharmacology
- Pain Management and Opioid Use
- Neurosurgical Procedures and Complications
- Bone fractures and treatments
- Cervical and Thoracic Myelopathy
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Shoulder and Clavicle Injuries
- Airway Management and Intubation Techniques
- Retinal Diseases and Treatments
- Orthopaedic implants and arthroplasty
Kyungpook National University
2025
Samsung Medical Center
2015-2024
Sungkyunkwan University
2015-2024
Catholic University of Korea
2009-2022
Kangbuk Samsung Hospital
2018-2021
Kyungsung University
2020
Hallym University
1999-2017
Kangdong Sacred Heart Hospital
2002-2017
Sahmyook Medical Center
2014
Gyeongsang National University Hospital
2012
The aim of this study was to compare CT and MRI at 0.5 T in the preoperative staging uterine cervical cancer a large series patients.Ninety-nine patients with carcinoma underwent CT, MRI, surgical exploration.Both MR findings were compared using surgical-pathologic as gold standards. Magnetic resonance imaging superior tumor detection (sensitivity 75 vs. 51%, p < 0.005), parametrial evaluation (accuracy 87 80%, overall 77 69%, 0.025), pelvic lymph node 88 83%, 0.01). had an accuracy 76%...
Objective To investigate the incidence of postoperative sore throat (POST) in Korean patients undergoing general anaesthesia with endotracheal intubation and to assess potential risk factors. Methods This prospective study enrolled who underwent all types elective surgical procedures anaesthesia. The were categorized into group S (those a POST) or N without POST). demographic, clinical anaesthetic characteristics each compared. Results 207 overall POST was 57.5% ( n = 119). Univariate...
There are no specific tools for measurement of the severity chronic cough in Korea. We developed a Korean version Leicester Cough Questionnaire (LCQ) and tested its scaling clinical properties.The LCQ was adapted conditions following forward-backward translation procedure. All patients referred to clinics at 5 university hospitals between May 2011 October 2013 completed 2 questionnaires, Short-Form 36 (SF-36), upon presentation Global Rating Change (GRC) follow-up visits after or 4 weeks....
Abstract Current sepsis biomarkers may be helpful in determining organ failure and evaluating patient clinical course; however, direct molecular to predict subsequent have not yet been discovered. Exosomes, a small population of extracellular vesicles, play an important role the inflammatory response, coagulation process cardiac dysfunction sepsis. Nonetheless, association plasma exosome with severity mortality is well known. Therefore, overall levels patients were assessed whether...
Abstract The role of high-mobility group box-1 (HMGB1) in outcome prediction sepsis is controversial. Furthermore, its association with necroptosis, a programmed cell necrosis mechanism, still unclear. purpose this study to identify the between plasma levels HMGB1 and severity clinical outcomes sepsis, examine correlation key executors necroptosis including receptor-interacting kinase 3 (RIPK3) mixed lineage domain-like- (MLKL) proteins. Plasma HMGB1, RIPK3, MLKL were measured enzyme-linked...
In the thoracic spine, when disc herniation causes cord compression in anterior region, it is difficult to access space. When using unilateral biportal endoscopy (UBE) technique, can be accessed from various angles with minimal damage normal tissue. We performed cage insertion UBE treating a patient myelopathy due proximal junctional failure spine. A 77-year-old woman prior spinal fusions and recent kyphosis presented myelopathy. The first visited our hospital gait instability decreased...
Lymph node (LN) metastasis is one of the most important adverse prognostic factors for pancreatic cancer. The aim this study was to identify novel lymphatic metastasis-associated markers DNA microarray analysis used determine and compare expression profiles 17 cancer tissues with LN without metastasis. results were validated by real-time reverse transcription-polymerase chain reaction immunohistochemistry. Only 58 genes differentially expressed between two groups a difference in signal...
Abstract Background Drug reaction with eosinophilia and systemic symptoms ( DRESS ) syndrome is a rare adverse drug reaction. This study aimed to evaluate the incidence of association individual drugs, clinical manifestations, disease course, outcomes . Methods Using criteria European Registry Severe Cutaneous Adverse Reactions (Regi SCAR ), medical records 25 patients diagnosed between 2006 2015 were retrospectively reviewed. Demographic data, culprit latency periods, laboratory findings,...
Necroptosis is a form of programmed necrotic cell death that rapidly emerging as an important pathophysiological pathway in numerous disease states. dependent on receptor-interacting protein kinase 3 (RIPK3), shown to play role experimental models critical illness. However, there limited clinical evidence regarding the extracellular RIPK3 human illness.Plasma levels were measured 953 patients prospectively enrolled 5 ongoing intensive care unit (ICU) cohorts both USA and Korea....
: Although early recognition of sepsis is essential for timely treatment and can improve outcomes, no marker has demonstrated sufficient discriminatory power to diagnose sepsis. This study aimed compare gene expression profiles between patients with healthy volunteers determine the accuracy these in diagnosing predict outcomes by combining bioinformatics data molecular experiments clinical information. We identified 422 differentially expressed genes (DEGs) control groups, which 93...
In Brief BACKGROUND: Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer chemotherapeutic drugs. Hyperalgesia common component neuropathic pain. Ginkgo biloba extract (GBE) an oriental herbal medicine that has various pharmacological actions. this study, we evaluated the effects oral GBE on hyperalgesia in rat model vincristine-induced neuropathy. METHODS: Male Sprague-Dawley rats (200–250 g) were injected intraperitoneally with vincristine or saline...
It is widely accepted that cervical interlaminar steroid injection (CIESI) more effective in treating radicular pain than axial neck pain, but without direct comparison. And the differences of effect after CIESI according to MRI findings are inconsistent. In this retrospective study, we evaluated therapeutic response sites, durations, findings, and other predictive factors altogether, unlike previous studies, which them separately.The medical records 128 patients who received fluoroscopy...
Chemotherapy-induced neuropathic pain is a disabling condition following cancer treatment. Vincristine has more neurotoxicity than other vinca alkaloid agents. This study evaluated the correlation of different doses nefopam with antiallodynic effects in mouse vincristine neuropathy model.A peripheral model was made by intraperitoneal injection (0.1 mg/kg/day; 5-day-on, 2-day-off schedule over 12 days). After development allodynia, mice were injected intraperitoneally 0.9% normal saline (NS...
Abstract CD63 is one of the tetraspanin protein family members that ubiquitously expressed on exosomes and involved in signal transduction various types immune cells. It may thus contribute to immunometabolic mechanisms cellular organ dysfunction sepsis. Nonetheless, association exosomal with severity mortality sepsis not well known. Therefore, present study, overall levels were evaluated ascertain whether they associated failure patients Exosomal was measured from prospectively enrolled...
Abstract Background Despite the understanding of sepsis-induced extracellular vesicles (EVs), such as exosomes, and their role in intercellular communication during sepsis, little is known about EV contents microRNA (miRNA), which modulate important cellular processes contributing to sepsis body fluids. This study aimed analyze differential expression exosomal miRNAs plasma samples collected from patients healthy controls, identify potential miRNA regulatory pathways pathogenesis. Methods...
Recent studies have suggested that TNF-related apoptosis-inducing ligand (TRAIL) is associated with mortality in sepsis, possibly through necroptosis. The objective of this study was to analyze the association between plasma level TRAIL and sepsis severity outcomes. Furthermore, compared receptor-interacting protein kinase-3 (RIPK3), a key executor necroptosis, identify any correlation Plasma levels RIPK3 from consecutively enrolled critically ill patients were measured by ELISA. Of 190...
The Cough Symptom Score (CSS) is a simple, useful tool for measuring cough severity. However, there no standard Korean version of the CSS. We developed CSS and evaluated its clinical utility validity assessing chronic severity.The was adapted use following forward-backward translation procedure. Patients with enrolled from five university hospitals were graded using 100-mm linear visual analog scale (VAS) severity at each visit. completed Leicester Questionnaire (LCQ) upon presentation LCQ...
Background There is a need for investigating the analgesic method as part of early recovery after surgery tailored laparoscopic colorectal cancer (LCRC) surgery. In this randomized trial, we aimed to investigate efficacy an inverse 'v' shaped bilateral, subfascial ropivacaine continuous infusion in LCRC Methods Forty two patients undergoing elective were randomly allocated one groups receive either 0.5% at plane (n = 20, R group) or fentanyl intravenous patient controlled analgesia (IV PCA)...
Purpose—This study was conducted to develop an automated detection algorithm for screening fundus abnormalities, including age-related macular degeneration (AMD), diabetic retinopathy (DR), epiretinal membrane (ERM), retinal vascular occlusion (RVO), and suspected glaucoma among health program participants. Methods—The development dataset consisted of 43,221 photographs (from 25,564 participants, mean age 53.38 ± 10.97 years, female 39.0%) from a patients the Kangbuk Samsung Hospital...