A5005825482- Muscle Physiology and Disorders
- Cellular Mechanics and Interactions
- Veterinary medicine and infectious diseases
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Calpain Protease Function and Regulation
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Gynecological conditions and treatments
- Physiological and biochemical adaptations
- Advanced biosensing and bioanalysis techniques
- Mycobacterium research and diagnosis
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Zebrafish Biomedical Research Applications
- Sarcoma Diagnosis and Treatment
- DNA and Nucleic Acid Chemistry
- Protein Tyrosine Phosphatases
- Diphtheria, Corynebacterium, and Tetanus
- Retinal Development and Disorders
Umeå University
2021-2024
Instituut voor Tropische Geneeskunde
2014
Northeast Normal University
2013
Abstract Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy that DBI preferentially localizes in intraluminal vesicles (ILVs), precursors exosomes, which are key components cancer cell proliferation. Moreover, purified exosomal DNA was recognized...
Abstract In muscular dystrophies, muscle fibers loose integrity and die, causing significant suffering premature death. Strikingly, the extraocular muscles (EOMs) are spared, functioning well despite disease progression. Although EOMs have been shown to differ from body musculature, mechanisms underlying this inherent resistance dystrophies remain unknown. Here, we demonstrate important differences in gene expression as a response between trunk zebrafish via transcriptomic profiling. We show...
Migrating muscle progenitors delaminate from the somite and subsequently form tissue in distant anatomical regions such as paired appendages, or limbs. In amniotes, this process requires a signaling cascade including transcription factor box 3 (Pax3).In study, we found that, unlike mammals, pax3a/3b double mutant zebrafish develop near to normal appendicular muscle. By analyzing numerous combinations of pax3a, pax3b pax7a, pax7b, determined that there is feedback system compensatory...
Uterus development during pre-implantation stage affects implantation process and embryo growth. Aberrant uterus is associated with many human reproductive diseases. Among the factors regulating development, vascular remodeling promoters are critical for function fertility. Vascular endothelial growth factor (VEGF), as one of major members, has been found to be important in cell blood vessel well non-endothelial cells. VEGF mediation reproduction broadly studied, but VEGF-induced...
A study was conducted on 400 goats in Luna Export Abattoir originated from district area of Borena Range land (that is Yabello and Negella) November, 2008 to April, 2009 estimate the prevalence caseous lymphadenitis (CLA) goats. Detail post mortem examination bacteriology were applied undertake this study. On bases bacteriological results, 15% (60/400), out which 42 (70%), 13 (21.7%) 5 (8.3%) cutaneous form, visceral form generalized respectively. There statistical significance difference (P...
Abstract Rhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations myogenic progenitors lead ineffective differentiation and malignant transformation. The transcription factors Pax3 Pax7 their downstream target genes are tightly linked with the fusion positive alveolar subtype, whereas RAS pathway usually involved embryonal, negative variant. Here, we analyse role of context, by linking alterations gene expression pax3a/pax3b double mutant zebrafish tumour...
Purpose: The cytoskeleton of the extraocular muscles (EOMs) is significantly different from that other muscles. We aimed to investigate role obscurin, a fundamental cytoskeletal protein, in EOMs. Methods: distribution obscurin human and zebrafish EOMs was compared using immunohistochemistry. two genes zebrafish, obscna obscnb, were knocked out CRISPR/Cas9, investigated immunohistochemistry, qPCR, situ hybridization. optokinetic reflex (OKR) five-day-old larvae adult obscna−/−;obscnb−/−...
Abstract In muscular dystrophies, muscle fibers loose integrity and die, leading to significant suffering a shorter life. Strikingly, the extraocular muscles (EOMs), controlling eye movements, are spared function well despite disease progression. Although EOMs have been shown important differences compared body musculature mechanisms underlying this inherent resistance dystrophies remain largely unknown. Here, we demonstrate in gene expression as response between trunk zebrafish via...