A5017351938- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Organic Light-Emitting Diodes Research
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Organic Electronics and Photovoltaics
- Liquid Crystal Research Advancements
- Synthesis and Catalytic Reactions
- Nonlinear Dynamics and Pattern Formation
- Synthesis and Biological Evaluation
- Luminescence Properties of Advanced Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced biosensing and bioanalysis techniques
- Enzyme function and inhibition
- DNA and Nucleic Acid Chemistry
- Conducting polymers and applications
- Photochromic and Fluorescence Chemistry
- Photochemistry and Electron Transfer Studies
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Spectroscopy and Quantum Chemical Studies
- Catalytic Cross-Coupling Reactions
- Organic Chemistry Cycloaddition Reactions
Centre National de la Recherche Scientifique
2022-2025
Institut des Sciences et Technologies Moléculaires d'Angers
2022-2025
Institut des Sciences Moléculaires
2024
Université d'Angers
2024
Abstract Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy that DBI preferentially localizes in intraluminal vesicles (ILVs), precursors exosomes, which are key components cancer cell proliferation. Moreover, purified exosomal DNA was recognized...
Abstract Efficient type II photodynamic therapy (PDT) requires stable and biocompatible photosensitizers (PS) that present low dark cytotoxicity, are photo‐excitable in deep tissue regions, can efficiently penetrate kill cells via situ singlet oxygen production. Here, heavy‐metal‐free organic PS combined with near‐infrared (NIR)‐excitable small (<20 nm) upconversion nanoparticles (UCNPs) into UCNP‐PS nanohybrids for accomplishing such advanced PDT conditions. UCNP‐to‐PS energy transfer...
Controlling the formation of photoexcited triplet states is critical for many (photo)chemical and physical applications. Here, we demonstrate that a permanent out-of-plane distortion benzothioxanthene imide (BTI) dye promotes intersystem crossing by increasing spin-orbit coupling. This manipulation was achieved through subtle chemical modification, specifically bay-area methylation. Consequently, this simple yet efficient approach expands catalog known molecular engineering strategies...
The sulfoxide moiety is one of the most commonly utilized groups in pharmaceutical and industrial chemistry. need for sustainability easy accessibility to moieties deemed necessary, due its ubiquity natural products potentially pharmaceutically active compounds. In this context, we report herein a sustainable, aerobic environmentally friendly photochemical protocol based on use benzothioxathene imide as photocatalyst selectively oxidize sulfides under mild irradiation (456 nm), very low...
Schematic illustration of the twisted π-conjugated system strategy to achieve enhanced fluorescence emission and ROS generation efficiency.
Modern photodynamic therapy (PDT) demands next-generation photosensitizers (PSs) that overcome heavy-atom dependency and enhance efficacy beyond traditional, highly oxygen-dependent type II mechanisms. We introduce herein TCI-NH, as a thiochromenocarbazole imide derivative designed for I action. Upon light activation, TCI-NH efficiently favors superoxide (O2•-) PS-centered radical formation instead of singlet oxygen (1O2) generation. Its high luminescence efficiency selective localization in...
A series of thiochromenocarbazole imide (TCI) photosensitizers featuring carbonic anhydrase inhibitors (CAi) was designed to alleviate the consequences PDT-induced hypoxia by merging advantages hCA IX knockdowns with PDT.
Updated synthesis of the BTI from cheap commercially available reactants in less than 4 hours owing to microwave irradiations through a two step and column-free procedure.
Liquid crystals (LCs) have garnered significant attention for their unique optical and electrical properties, making them promising candidates in various technological applications such as smart displays, sensors, telecommunications, biomedicals or wearable electronics. In this study, we explore the potential of several highly emissive benzothioxanthene imide (BTI) derivatives LC materials with a focus on robustness temperature-stable emission behavior. By tailoring molecular structure BTIs,...
Liquid crystals (LCs) have garnered significant attention for their unique optical and electrical properties, making them promising candidates in various technological applications such as smart displays, sensors, telecommunications, biomedicals or wearable electronics. In this study, we explore the potential of several highly emissive benzothioxanthene imide (BTI) derivatives LC materials with a focus on robustness temperature-stable emission behavior. By tailoring molecular structure BTIs,...
Photodynamic Theranostics In article number 2410077, Clément Cabanetos, Niko Hildebrandt, and co-workers demonstrate efficient singlet oxygen production by heavy-metal free organic photosensitizers functionalized to the surface of upconversion nanoparticles. The sub-20 nm nanophotosensitizers can be excited in NIR (808 980 nm) used for simultaneous imaging cancer cell destruction.
Subtle chemical modifications of an intermediate can have significant impacts, since they usually considered to control the reactivity. In their Research Article, J. Zagranyarski, D. Lungerich, C. Cabanetos, and co-workers report preparation aza derivatives benzothixanthene imide. The intramolecular radical cyclization be controlled by means a simple methylation either afford thermodynamically favored six-membered or its kinetically five-membered ring regioisomers, exhibiting photophysical...
Abstract Displays have become ubiquitous in our modern and highly interconnected lives. Complex vacuum processed multi‐stacks are widely integrated into high tech, value products such as smart phones, while solution large area single‐layer OLEDs appear more adequate for basic applications focusing on recyclability packaging, road signage, advertising, single‐use health care products. In this context, we report herein the design, synthesis, characterization of an accessible series...
Abstract Two synthetic organic dyes of the Benzothioxanthene imide (BTI) family are explored as a promising electroactive material for light‐emitting electrochemical cells (LECs). The high thermal stability and ease thin film processing make BTI‐based compounds suitable these devices. However, their planar π‐conjugated structure often leads to aggregation‐caused quenching (ACQ), reducing luminescence in solid state. To overcome this, this study has taken advantage host‐guest interactions...
Abstract While benzothioxanthene imide ( BTI ) has shown promise in organic electronics and more recently photodynamic therapy, its full potential remains yet undiscovered. In this context, study repots the synthesis characterization of aza derivatives which characteristic sulfur atom is replaced by an amino group. Adapted from synthetic route , a way was found to control electronic structure radical intermediates, means simple chemical modification. As result, either thermodynamically...