A5076678012- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Organic Light-Emitting Diodes Research
- Nonlinear Dynamics and Pattern Formation
- Liquid Crystal Research Advancements
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Photodynamic Therapy Research Studies
- Organic Chemistry Cycloaddition Reactions
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Advanced biosensing and bioanalysis techniques
- Synthesis and Biological Evaluation
- RNA Interference and Gene Delivery
- Luminescence Properties of Advanced Materials
- DNA and Nucleic Acid Chemistry
Centre National de la Recherche Scientifique
2022-2024
Institut des Sciences et Technologies Moléculaires d'Angers
2022-2024
Université d'Angers
2024
Abstract Photodynamic therapy (PDT) ideally relies on the administration, selective accumulation and photoactivation of a photosensitizer (PS) into diseased tissues. In this context, we report new heavy-atom-free fluorescent G-quadruplex (G4) DNA-binding PS, named DBI. We reveal by fluorescence microscopy that DBI preferentially localizes in intraluminal vesicles (ILVs), precursors exosomes, which are key components cancer cell proliferation. Moreover, purified exosomal DNA was recognized...
Abstract Efficient type II photodynamic therapy (PDT) requires stable and biocompatible photosensitizers (PS) that present low dark cytotoxicity, are photo‐excitable in deep tissue regions, can efficiently penetrate kill cells via situ singlet oxygen production. Here, heavy‐metal‐free organic PS combined with near‐infrared (NIR)‐excitable small (<20 nm) upconversion nanoparticles (UCNPs) into UCNP‐PS nanohybrids for accomplishing such advanced PDT conditions. UCNP‐to‐PS energy transfer...
Schematic illustration of the twisted π-conjugated system strategy to achieve enhanced fluorescence emission and ROS generation efficiency.
Updated synthesis of the BTI from cheap commercially available reactants in less than 4 hours owing to microwave irradiations through a two step and column-free procedure.
Liquid crystals (LCs) have garnered significant attention for their unique optical and electrical properties, making them promising candidates in various technological applications such as smart displays, sensors, telecommunications, biomedicals or wearable electronics. In this study, we explore the potential of several highly emissive benzothioxanthene imide (BTI) derivatives LC materials with a focus on robustness temperature-stable emission behavior. By tailoring molecular structure BTIs,...
Liquid crystals (LCs) have garnered significant attention for their unique optical and electrical properties, making them promising candidates in various technological applications such as smart displays, sensors, telecommunications, biomedicals or wearable electronics. In this study, we explore the potential of several highly emissive benzothioxanthene imide (BTI) derivatives LC materials with a focus on robustness temperature-stable emission behavior. By tailoring molecular structure BTIs,...
Photodynamic Theranostics In article number 2410077, Clément Cabanetos, Niko Hildebrandt, and co-workers demonstrate efficient singlet oxygen production by heavy-metal free organic photosensitizers functionalized to the surface of upconversion nanoparticles. The sub-20 nm nanophotosensitizers can be excited in NIR (808 980 nm) used for simultaneous imaging cancer cell destruction.
Subtle chemical modifications of an intermediate can have significant impacts, since they usually considered to control the reactivity. In their Research Article, J. Zagranyarski, D. Lungerich, C. Cabanetos, and co-workers report preparation aza derivatives benzothixanthene imide. The intramolecular radical cyclization be controlled by means a simple methylation either afford thermodynamically favored six-membered or its kinetically five-membered ring regioisomers, exhibiting photophysical...
Abstract Two synthetic organic dyes of the Benzothioxanthene imide (BTI) family are explored as a promising electroactive material for light‐emitting electrochemical cells (LECs). The high thermal stability and ease thin film processing make BTI‐based compounds suitable these devices. However, their planar π‐conjugated structure often leads to aggregation‐caused quenching (ACQ), reducing luminescence in solid state. To overcome this, this study has taken advantage host‐guest interactions...
Abstract While benzothioxanthene imide ( BTI ) has shown promise in organic electronics and more recently photodynamic therapy, its full potential remains yet undiscovered. In this context, study repots the synthesis characterization of aza derivatives which characteristic sulfur atom is replaced by an amino group. Adapted from synthetic route , a way was found to control electronic structure radical intermediates, means simple chemical modification. As result, either thermodynamically...