A5073442368- MicroRNA in disease regulation
- Hepatitis C virus research
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Enzyme Production and Characterization
- Seaweed-derived Bioactive Compounds
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced biosensing and bioanalysis techniques
- Marine Sponges and Natural Products
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- CRISPR and Genetic Engineering
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Free Radicals and Antioxidants
- Synthesis and Characterization of Heterocyclic Compounds
- Estrogen and related hormone effects
- Synthesis and biological activity
- Biopolymer Synthesis and Applications
- PARP inhibition in cancer therapy
Dar Al Uloom University
2025
National Research Centre
2014-2024
Cairo University
2010
Background and Objectives: Changes in biomarker status are not rare usually occur an unfavorable direction. Evaluating changes is advantageous for assessing treatment options prognosticating patients. Currently, only a few studies have explored the association between conversion breast cancer relapse. In this study, we sought to determine incidence of receptor conversions patients diagnosed with recurrent comparison their corresponding primary tumors evaluate possible influencing factors....
Abstract Hepatocellular carcinoma (HCC) is the major life-threatening primary liver malignancy in both sexes all over world. Unfortunately, majority of patients are diagnosed at later stages because HCC does not elicit obvious symptoms during its early incidence. Consequently, most individuals escape first-line treatments and treated with chemotherapy. Regrettably, therapeutic outcomes for those usually poor development multidrug resistance phenomena. Furthermore, anti-HCC therapies cause...
Objective: Exopolysaccharides gained attention as new source for cancer treatment recent treatments cause side effects and multidrug resistance. Polysaccharides containing sulfur uronic acids exhibited antioxidant activity, by restoring cell redox regulation, thus inhibiting proliferation formation. Following this context, our study was performed to assess the cytotoxic activity of exopolysaccharides produced novel Egyptian marine bacterial strains on HepG2 cells. Methods: Bacteria were...
Hepatocellular carcinoma (HCC) is the major lethal primary liver malignant worldwide. Although, melatonin has various antitumor bioactivities; there a requirement for more investigations to elucidate not discussed effects, and controversial responses of treatment with on targets mediated in HCC. To achieve aim present study, HCC-HepG2 cells were treated different concentrations at time intervals. The selected minimal proliferation inhibition doses then incubated examine arresting effect...
Abstract Purpose Breast cancer is one of the leading types diagnosed in women. Despite improvements chemotherapeutic cure strategies, drug resistance still an obstacle to disease aggressiveness. The small non-coding RNA molecules, miRNAs, have been implicated recently be involved as regulators gene expression through silencing mRNA targets that contributed several cellular processes related metastasis. Hence, present study aimed investigate beneficial role and mechanism miRNA-34a-based...
Chemotherapeutic drugs have high toxicity associated with undesirable side-effects. Now, natural products are the most important anti-cancer agents because of their low and potential effectiveness.The half maximal inhibitory concentration (IC50) amygdalin, naringenin ellagic acid against breast, colon, liver cell lines was estimated. The antimutagenic, free radical-, superoxide hydroxyl radical- scavenging activities these phytochemicals were measured. expression p53, bid, bax, bcl2,...
The aim of the current study based on production and characterization exopolysaccharides (EPSs) isolated from marine sediment Mediterranean Red Seas is to its cytotoxic activity against HepG2 cells. Eleven isolates have ability produce EPSs also decreased viability cell line in different manners. five most promising that high yield cytotoxicity were identified by 16S RNA as Brevundimonas subvibrioides MSA1, Bacillus thuringiensis E4, amyloliquefaciens MGA2, Pseudomonas fluorescens SGA3,...
Multidrug resistance (MDR) in various kinds of cancers represents a true obstacle which hinders the successes most current available chemotherapies. ATP-binding cassette (ABC) trasporter proteins have been shown to contribute majority MDR types malignancies. c-myc has recently reported participate, at least partly, some cancers. This study aimed test whether could play role, solely or with coordination other ABCs, HepG2 cells doxorubicin (Dox). induced wild-type and verified both on gene...
Background: Colorectal cancer is among the leading causes of death worldwide. The incidence deaths expected to be 11.4 million in 2030. Objective: We aimed evaluate vitro and vivo antioxidant antitumor activities a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal rats. Methods: antiproliferative activity BFB HCT-116 colon cells apoptotic genes was assessed. In study also conducted which 80 adult male rats were divided into 5 groups; control, BFB, other 3 groups...