A5062694093- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Hepatitis B Virus Studies
- Bioactive Compounds and Antitumor Agents
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Seaweed-derived Bioactive Compounds
- Synthesis and biological activity
- Diabetes and associated disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Inflammatory mediators and NSAID effects
- Cancer therapeutics and mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Fungal Plant Pathogen Control
- Medical and Biological Sciences
- Bone Metabolism and Diseases
- Gastrointestinal motility and disorders
- Steroid Chemistry and Biochemistry
- Phytochemistry and Bioactivity Studies
- Bone health and treatments
- Synthesis of heterocyclic compounds
National Research Centre
2009-2021
Cairo University
1993-2010
University of Toronto
2004-2006
University Health Network
2004-2006
Toronto Western Hospital
2004
University of Pennsylvania
1997
The new natural flavonoid compounds – diosmetin 7‐O‐β‐L‐arabinofuranosyl (1 → 2) β‐D‐apiofuranoside (1) and 7‐O‐β‐D‐apiofuranoside (2) were isolated from the acetone extract of date fruits epicarp belonging to family Arecaceae (Palmae). Elucidation their chemical structures was determined by different spectroscopic methods in addition physical analysis. These assessed for biological activity on alloxan diabetic rats. A dose 1.5 ml suspensions/100 gm b. wt orally administrated rats 30 days....
Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which believed be responsible for the mutagenic and carcinogenic activities. This study was carried out investigate early changes that may related activity of acrylamide in thyroid, adrenal glands testis male rats. Forty adult Sprague Dawley rats were divided equally into four groups, Group I served as control, Groups II, III IV treated orally with doses 5, 10, 15 mg/kg/day body weight 8 weeks. The...
1 The antitumour activities of extracts from the Red Sea seaweeds Jania rubens, Sargassum subrepandum, and Ulva lactuca were investigated in an vivo mice model based on intramuscular injection Ehrlich ascites tumour cells. In parallel, antioxidant measured. Tumour marker levels, liver biochemical parameters, hepatic oxidant/antioxidant status measured to prove anticancer nature algal extracts. Significant decreases carcinoembryonic antigen (CEA) α-fetoprotein (AFP) enzymes, levels nitric...
Developing new therapeutic agents that can overcome gastrointestinal injury and at the same time could lead to an enhanced anti-inflammatory effect becomes urgent need for inflammation patients. Thiazolyl pyrrolyl steroids were synthesized via straight forward efficient methods their structures established based on correct elemental analysis compatible IR, (1) H-NMR, (13) C-NMR, mass spectral data. The dihydrothiazolyl-hydrazonoprogesterone 12 aminopyrrolylprogesterone 16a showed...
This approach was designed to explore the influence of quercetin on distinct molecular pathways implicated in breast cancer evolution. The cytotoxic impact two cell lines, MCF-7 and MDA-MB-231 quantified via MTT assay. expression levels selected genes involved apoptosis, proliferation, progression, invasion metastases were analyzed using RT-PCR. outcomes present study explicated that exhibited suppression effect with IC50 = 151 958µM respectively after 48 h incubation time. Furthermore,...
This study aimed to appraise the activity of Pterocladia capillacea and Corallina officinalis polysaccharides against Breast Cancer Stem Cells (BCSCs). P. C. were characterized be sulfated polysaccharide-protein complexes. Cytotoxicity MDA-MB-231 MCF-7 cell lines along with their impact on CD44+/CD24- aldehyde dehydrogenase 1(ALDH1) positive BCSC population determined. Their effect gene expression CSC markers, Wnt/β-catenin Notch signaling pathways was evaluated. inhibited growth breast...
Current estimates indicate that the hepatitis C (HCV) is leading cause of mortality around world, with infection rates steadily increasing in Egypt. The dual therapy for this silent epidemic pegylated-interferon-α2b/ribavirin has markedly improved success genotype-4 patients. It was reported apoptosis plays a vital mechanistic role limiting viral replication. P53, key regulator apoptosis, induces CD95 gene expression and subsequently initiates apoptotic cascade to be activated. current study...