A5046581226- Ocular and Laser Science Research
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Rheumatoid Arthritis Research and Therapies
- Ophthalmology and Visual Impairment Studies
- Glaucoma and retinal disorders
- Bone health and treatments
- Spondyloarthritis Studies and Treatments
- Bone Metabolism and Diseases
- Infrared Target Detection Methodologies
- Corneal surgery and disorders
- Psoriasis: Treatment and Pathogenesis
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Bone health and osteoporosis research
- Cardiac tumors and thrombi
- Diverse Scientific Research Studies
- Aortic Disease and Treatment Approaches
- Advanced Optical Imaging Technologies
- Dermatological and Skeletal Disorders
- Retinal Imaging and Analysis
- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- Infrared Thermography in Medicine
- Thyroid Disorders and Treatments
Nicolaus Copernicus University
2015-2024
Institute of Physics
2018-2024
Augenklinik Heidelberg
2024
Apple (Germany)
2024
Czech Academy of Sciences, Institute of Physics
2019
Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field.Historically, visible light has been described as ranging from 400 720 nm.However, we previously demonstrated that infra-red can initiate transduction in rod photoreceptors by mechanism two-photon absorption pigments.Here introduce newly designed constructed microperimeter.We provide for first time evidence presence nonlinear process occurring human...
Two-photon vision relies on the perception of pulsed infrared light due to two-photon absorption in visual pigments. This study aimed measure human pupil reaction caused by a 1040-nm stimulus and compare it with responses elicited 520-nm stimuli similar color.Pupillary reflex (PLR) was induced 14 dark-adapted healthy subjects. Three types fovea-centered 3.5° diameter were tested: spirals formed fast scanning (infrared [IR] laser) or (visible [VIS] laser beams uniformly filled circle created...
The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that normal aging. Microperimetry was performed with visible (white) light infrared (IR) light, which perceived as green stimulation. total, 45 subjects were included one (better) eye studied. Furthermore, best-corrected...
Two-photon absorption occurring in photoreceptors of human eye is responsible for perception pulsed infrared laser beams. Color perceived light corresponds to about half wavelength stimulating beam. This recently discovered phenomenon called two-photon vision. However it yet not clear how such phenomena could impact an ophthalmic diagnosis and therefore further studies are required. In this paper we present the system that enables future psychophysical experiments extend knowledge vision its...
Two-photon vision is a new and developing field in science. The phenomenon based on visual perception of pulsed infrared lasers (800-1300 nm) due to the isomerization pigments caused by two-photon absorption, with color corresponding wavelength about one-half stimulating near-infrared spectral range. Future applications this effect, both medical diagnostics virtual/augmented reality (VR/AR), require ability determine luminance stimuli. However, luminous efficiency function V ( λ ) outside...
Purpose: The purpose of this study was to investigate the impact calcium and phosphorus levels on optical deterioration in primary secondary intraocular lens (IOL) calcification. Methods: A total 18 explanted IOLs, 10 with primary, 8 calcification, were examined. Straylight light loss evaluated as predictors impairment. individual amount determined using thermogravimetry followed by emission spectroscopy (ICP-OES). relationship between calcification impairment investigated. Results: Primary...
Background: This study aimed to evaluate the efficacy and safety of secukinumab 150 mg compared with placebo in management spinal pain disease activity patients axial spondyloarthritis (axSpA) at Week 8 up 24. Methods: Patients ( n = 380) active axSpA were randomized (3:1) (Group A) or B). At 8, from Group A an average score <4 defined as responders re-assigned (Arm A1); whereas non-responders re-randomized 150/300 A2/A3). B (1:1) B1/B2). Results: odds achieving significantly higher for...
The aim of this paper is to present a novel method, called Adaptive Edge Detection (AED), extraction precise pupil edge coordinates from eye image characterized by reflections external illuminators and laser beams. method used for monitoring size position during psychophysical tests two-photon vision performed dedicated optical set-up. Two-photon new phenomenon perception short-pulsed near infrared beams focused on human retina as having color half their wavelength it caused absorption...
Abstract Background/Aims SKIPPAIN (NCT03136861) is the first randomised controlled study involving a biological disease-modifying anti-rheumatic drug, with primary endpoint of spinal pain at Week 8 in patients axial spondyloarthritis (axSpA; ankylosing spondylitis [AS] and non-radiographic [nr]-axSpA). We present 24-week results secukinumab reducing disease activity following step-up dosing. Methods This double-blind, placebo-controlled Phase 3b enrolled (aged ≥18 years) active (BASDAI ≥4;...
Two-photon vision relies on the perception of pulsed near-infrared laser beams as having colors like their half-wavelength counterparts. The phenomenon is due to two-photon absorption occurring in visual pigments [1]. This study focused methods determine contrast sensitivity function (CSF) for vision, which has not yet been investigated. CSF was measured eight spatial frequencies using tumbling E letter optotype. optotype projected a white background by fast scanning retina with 1040 nm or...
Light sensation relies on photoisomerization of chromophores in rod and cone photoreceptor cells. Spectral sensitivity these cells the retina is determined by absorption spectra their pigments which covers a range from 400 nm to above 700 nm. Regardless mechanism leading visual pigment isomerization, light triggered every time molecules change conformation. Thus, two-photon (TPA) should produce same result (visual sensation) as single photon light. This observation was positively verified...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)