A5102943923- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- High-Energy Particle Collisions Research
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Cardiovascular Function and Risk Factors
- Nuclear physics research studies
- Strong Light-Matter Interactions
- Cold Atom Physics and Bose-Einstein Condensates
- Particle Detector Development and Performance
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Nonlinear Photonic Systems
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Pulsars and Gravitational Waves Research
- Viral Infections and Immunology Research
- Transplantation: Methods and Outcomes
- Particle Accelerators and Free-Electron Lasers
- Artificial Intelligence in Healthcare
- Experimental and Theoretical Physics Studies
- Fetal and Pediatric Neurological Disorders
- Cardiac Valve Diseases and Treatments
University of California, San Francisco
2014-2024
CEA Paris-Saclay
2023-2024
Berry (United States)
2015-2024
Ohio University
2019-2024
University of Connecticut
2009-2024
Université Paris-Saclay
2023-2024
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023-2024
Institut de Recherche sur les Lois Fondamentales de l'Univers
2024
Czech Academy of Sciences, Nuclear Physics Institute
2022
University of California System
2021
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence that viral persistence, immune dysregulation, T cell dysfunction may play major roles. We performed whole-body positron emission tomography imaging in a well-characterized cohort 24 participants at time points ranging from 27 to 910 days acute using the radiopharmaceutical agent [
ABSTRACT The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral persistence immune dysregulation may play a major role. We performed whole-body positron emission tomography (PET) imaging in cohort 24 participants at time points ranging from 27 to 910 days acute using novel radiopharmaceutical agent, [ 18 F]F-AraG, highly selective tracer allows for...
We study numerically the outcome of phase separation instability a dual-species Bose-Einstein condensate in an optical lattice. When only one excitation mode is unstable bound pair bright and dark solitonlike structures periodically appears disappears, whereas for more than persistent soliton-antisoliton develops. The oscillating soliton represents regime where two-species neither remains phase-separated nor dynamically stable.
Single photon emission computed tomography (SPECT) myocardial perfusion imaging remains a critical tool in the diagnosis of coronary artery disease. However, after more than three decades use, detection efficiency poor and unchanged. This is due to continued reliance on parallel-hole collimators first introduced 1964. These possess geometric efficiency. Here we present performance evaluation results newly designed multipinhole collimator with 20 pinhole apertures (PH20) for commercial SPECT...
Several new technologies for single photon emission computed tomography (SPECT) instrumentation with parallel-hole collimation have been proposed to improve detector sensitivity and signal collection efficiency. Benefits from improved efficiency include shorter acquisition times lower dose requirements. In this paper, the authors show a possibility of over an order magnitude enhancement in detection (from 7.6 × 10(-5) 1.6 10(-3)) dopamine transporter (DaT) imaging striatum conventional SPECT...
Myocardial perfusion imaging (MPI) using slow rotating large field of view cameras requires spatiotemporal reconstruction dynamically acquired data to capture the time variation radiotracer concentration. In vivo, MPI contains additional degrees freedom involving unavoidable motion heart due quasiperiodic beating and effects respiration, which can severely degrade quality images. This work develops a technique for single photon emission computed tomography (SPECT) that reconstructs...
1][22][23] Gestational folic acid deficiency leads to impressive net reduction of cells in fetal brain and spinal cord. 24It can cause a wide array disorders the ranging from subtle changes intelligence profound mental retardation manifesting as severe damage learning capabilities or impaired adaptation abilities their environments. 25,26We therefore wanted test whether when given along with alcohol may reduce neurobehavioral impairments induced by mice. Methods AnimalsIn present study...
The reaction $\ensuremath{\gamma}p\ensuremath{\rightarrow}{K}^{+}\mathrm{\ensuremath{\Lambda}}(1520)$ using photoproduction data from the CLAS $g12$ experiment at Jefferson Lab is studied. decay of $\mathrm{\ensuremath{\Lambda}}(1520)$ into two exclusive channels, ${\mathrm{\ensuremath{\Sigma}}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$ and ${\mathrm{\ensuremath{\Sigma}}}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$, studied detected ${K}^{+}$, ${\ensuremath{\pi}}^{+}$,...
Myocardial infarction (MI) with subsequent inflammation is one of the most common heart conditions leading to progressive tissue damage. A reliable imaging marker assess viability after MI would help determine risks and benefits any intervention. In this study, we investigate whether a new mitochondria-targeted agent,
Nearly 70% of heart attacks (myocardial infarctions, MI) cases lead to a condition known as failure (HF), where the left ventricle (LV) remodels. Previous alginate and stem cell intramyocardial injection studies reported mixed outcomes using LV global volumetric function local myocardium mechanical response (strains stresses)1,2. Such measures involve unvalidated assumptions yielding erroneous results3. We conducted swine HF study treated with particular injection; however, instead response,...
The animals were housed in polypropylene cages with rice husk bedding.They fed on pelleted diet obtained from local Pashu Ahar kendra and tap water ad libitum.The female mice their pre-estrous phase transferred the evening to containing male ratio of 2:1.The presence vaginal plug following morning indicated pregnancy was designated as day zero (0) gestation.All pregnant divided into groups.Group-1 Treated equivalent amount during same days gestation.Group-2 desvenlafaxine GD 1 6 .Group-3 18...
The primary goal of this project is to implement the iterative statistical image reconstruction algorithm, in case maximum likelihood expectation (MLEM) used for dynamic cardiac single photon emission computed tomography, on Spark/GraphX. This involves porting algorithm run large-scale parallel computing systems. Spark an easy-to- program software platform that can handle large amounts data parallel. GraphX a graph analytic system running top and sparse linear algebra operations main...
Our approach differs from the usual global measure of cardiac efficiency by using PET/MRI to small pieces tissue whose limiting size is equal spatial resolution PET scanner. We initiated a dynamic study immediately prior injection 15.1 mCi
Modeling of data from a dynamic acquisition is complicated by the combination camera motion, organ and time-varying nature radionuclide distribution being imaged which results in inconsistent projection sets. Our approach to estimate time varying directly data. Entire tomographic slices or volumes are represented multiresolution spatiotemporal parameterization. The heart modeled using model that takes into account changes deformation as well intensity signal caused uptake washout...
Purpose Dynamic imaging ( DI ) provides additional diagnostic information in emission tomography comparison to conventional static at the cost of being computationally more challenging. single photon computed SPECT reconstruction is particularly difficult because limitations sampling geometry present most existing scanners. We have developed an algorithm Spline Initialized Factor Analysis Structures SIFADS that a matrix factorization method for reconstructing dynamics tracers tissues and...
In several nuclear cardiac imaging applications (SPECT and PET), images are formed by reconstructing tomographic data using an iterative reconstruction algorithm with corrections for physical factors involved in the detection process respiratory motion. The modeled as coefficients matrix of a system linear equations include attenuation, scatter, spatially varying geometric response. solution to problem involves solving inverse this matrix. This requires design statistical model that best...
Artificial Neural networks (ANNs) have been known to be suitable for various mathematical transformations. With the advent of GPU-based implementations NNs, they are making a significant impact on application artificial intelligence in medicine. In this project, we investigate NNs usefulness relation reconstruction Radon projection data. Medical image is type estimation problem. For example, estimate emission counts or absorption coefficients from noisy projections an image, also as...