Tyler‐Marie Deveau
A5053588106- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Inflammasome and immune disorders
- COVID-19 and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Virus-based gene therapy research
- Thermal Regulation in Medicine
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Multiple Sclerosis Research Studies
University of California, San Francisco
2022-2024
BACKGROUND. The presence and reactivation of chronic viral infections, such as EBV, CMV, HIV, have been proposed potential contributors to long COVID (LC), but studies in well-characterized postacute cohorts individuals with COVID-19 over a longer time course consistent current case definitions LC are limited.
Abstract Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global SARS-CoV-2-specific immunity in blood individuals with clear LC non-LC clinical trajectories, 8 months postinfection. found that exhibited systemic inflammation immune dysregulation. This was evidenced by differences T cell subset distribution implying...
Long COVID (LC), a type of post-acute sequelae SARS-CoV-2 infection (PASC), occurs after at least 10% infections, yet its etiology remains poorly understood. Here, we used multiple "omics" assays (CyTOF, RNAseq/scRNAseq, Olink) and serology to deeply characterize both global SARS-CoV-2-specific immunity from blood individuals with clear LC non-LC clinical trajectories, 8 months following prior receipt any vaccine. Our analysis focused on deep phenotyping T cells, which play important roles...
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence that viral persistence, immune dysregulation, T cell dysfunction may play major roles. We performed whole-body positron emission tomography imaging in a well-characterized cohort 24 participants at time points ranging from 27 to 910 days acute using the radiopharmaceutical agent [
Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH).We measured SARS-CoV-2-specific humoral cellular responses without recovering from COVID-19 ( n = 39 43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, inflammatory marker assays. We identified individuals experiencing postacute sequelae (PASC) evaluated parameters. used linear regression generalized models...
ABSTRACT The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral persistence immune dysregulation may play a major role. We performed whole-body positron emission tomography (PET) imaging in cohort 24 participants at time points ranging from 27 to 910 days acute using novel radiopharmaceutical agent, [ 18 F]F-AraG, highly selective tracer allows for...
The presence and reactivation of chronic viral infections such as Epstein-Barr virus (EBV), cytomegalovirus (CMV) human immunodeficiency (HIV) have been proposed potential contributors to Long COVID (LC), but studies in well-characterized post-acute cohorts individuals with COVID-19 over a longer time course consistent current case definitions LC are limited. In cohort 280 adults prior SARS-CoV-2 infection, we observed that symptoms fatigue neurocognitive dysfunction at median 4 months...
Abstract The associations between longitudinal dynamics and the breadth of SARS‐CoV‐2 neutralizing antibody (nAb) response with various Long COVID phenotypes before vaccination are not known. capacity antibodies to cross‐neutralize a variety viral variants may be associated ongoing pathology persistent symptoms. We measured cross‐neutralizing responses pre‐ post‐SARS‐CoV‐2 Omicron in participants infected early COVID‐19 pandemic, widespread rollout vaccines. Cross‐sectional regression models...
ABSTRACT Background Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH). Methods We measured specific humoral cellular responses without recovering from COVID-19 (n=39 n=43, respectively) using binding antibody, surrogate virus neutralization, intracellular cytokine staining, inflammatory marker assays. identified individuals experiencing post-acute sequelae (PASC) evaluated parameters. used linear regression...
The associations between longitudinal dynamics and the breadth of SARS-CoV-2 neutralizing antibody response with various Long COVID (LC) phenotypes prior to vaccination are not known. capacity antibodies cross neutralize a variety viral variants may be associated ongoing pathology persistent symptoms.